ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(7), P. 4254 - 4269
Published: June 12, 2024
The
skin,
being
the
largest
organ
of
human
body,
is
susceptible
to
damage
resulting
in
wounds
that
are
vulnerable
pathogenic
attacks
and
fail
provide
effective
protection
for
internal
tissues.
Therefore,
it
crucial
expedite
wound
healing.
In
recent
years,
microneedles
have
garnered
significant
attention
as
an
innovative
drug
delivery
system
owing
their
noninvasive
painless
administration,
simplified
application
process,
precise
control
over
release,
versatile
loading
capabilities.
Consequently,
they
hold
immense
potential
treatment
skin
wound.
This
review
presents
a
comprehensive
design
strategy
microneedle
promoting
First,
process
healing
characteristics
specific
elucidated.
strategies
subsequently
presented
classified
based
on
structural
therapeutic
methodologies.
Finally,
succinct
recapitulation
previously
discussed
points
prospective
analysis
provided.
Smart Medicine,
Journal Year:
2023,
Volume and Issue:
2(3)
Published: Feb. 19, 2023
Abstract
Wound
infections
continuously
impose
a
huge
economic
and
social
burden
on
public
healthcare.
Despite
the
effective
treatment
of
bacteria‐infected
wounds
after
using
traditional
antibiotics,
misuse
antibiotics
usually
causes
spread
bacterial
resistance
decreases
therapeutic
outcomes.
Therefore,
development
efficient
antibacterial
agents
is
urgently
needed.
Nanozymes,
as
new
generation
artificial
enzymes,
combine
intrinsic
abilities
nanomaterials
natural
enzymes.
Recently,
nanozymes
has
been
widely
developed
to
kill
bacteria
treat
wound
by
catalyzing
various
reactive
oxygen
species.
Thus,
this
concept
“antibacterial
nanozymes”
will
promote
further
advances
connecting
elimination.
To
highlight
these
achievements,
we
summarize
different
types
for
healing.
It
believed
that
such
promising
strategy
developing
make
great
contribution
in
field
skin
regeneration.
We
expect
play
significant
roles
both
basic
research
clinical
applications.
Lab on a Chip,
Journal Year:
2023,
Volume and Issue:
23(5), P. 869 - 887
Published: Jan. 1, 2023
This
review
summarizes
state-of-the-art
microneedle-based
detection
and
sensing
systems,
highlighting
the
objective
significance,
principles,
systematic
construction,
validation
models
of
these
microneedles.
Engineering,
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 1, 2023
Microneedles
(MNs)
can
be
used
for
the
topical
treatment
of
skin
disorders
as
they
directly
deliver
therapeutics
to
site
lesions,
resulting
in
increased
therapeutic
efficacy
while
having
minimum
side
effects.
MNs
are
different
kinds
(e.g.,
small
molecules,
macromolecules,
nanomedicines,
living
cells,
bacteria,
and
exosomes)
treating
various
disorders,
including
superficial
tumors,
wounds,
infections,
inflammatory
diseases,
abnormal
appearance.
The
improved
by
integrating
advantages
multiple
perform
combination
therapy.
Through
careful
designing,
further
modified
with
biomimetic
structures
responsive
drug
release
from
internal
external
stimuli
enhance
transdermal
delivery
efficiency
robust
outcomes.
Some
studies
have
proposed
use
drug-free
a
promising
mechanotherapeutic
strategy
promote
wound
healing,
scar
removal,
hair
regeneration
via
mechanical
communication
pathway.
Although
several
advantages,
practical
application
suffers
problems
related
industrial
manufacture
clinical
evaluation,
making
it
difficult
translation.
In
this
study,
we
summarized
applications,
emerging
challenges,
developmental
prospects
provide
information
on
ways
advance
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Feb. 6, 2024
Inflammatory
skin
disorders
can
cause
chronic
scarring
and
functional
impairments,
posing
a
significant
burden
on
patients
the
healthcare
system.
Conventional
therapies,
such
as
corticosteroids
nonsteroidal
anti-inflammatory
drugs,
are
limited
in
efficacy
associated
with
adverse
effects.
Recently,
nanozyme
(NZ)-based
hydrogels
have
shown
great
promise
addressing
these
challenges.
NZ-based
possess
unique
therapeutic
abilities
by
combining
benefits
of
redox
nanomaterials
enzymatic
activity
water-retaining
capacity
hydrogels.
The
multifaceted
effects
include
scavenging
reactive
oxygen
species
other
inflammatory
mediators
modulating
immune
responses
toward
pro-regenerative
environment
enhancing
regenerative
potential
triggering
cell
migration
differentiation.
This
review
highlights
current
state
art
NZ-engineered
(NZ@hydrogels)
for
regeneration
applications.
It
also
discusses
underlying
chemo-mechano-biological
mechanisms
behind
their
effectiveness.
Additionally,
challenges
future
directions
this
ground,
particularly
clinical
translation,
addressed.
insights
provided
aid
design
engineering
novel
hydrogels,
offering
new
possibilities
targeted
personalized
skin-care
therapies.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(33)
Published: June 14, 2024
Infectious
diseases
caused
by
bacterial,
viral,
and
fungal
pathogens
present
significant
global
health
challenges.
The
rapid
emergence
of
antimicrobial
resistance
exacerbates
this
issue,
leading
to
a
scenario
where
effective
antibiotics
are
increasingly
scarce.
Traditional
antibiotic
development
strategies
proving
inadequate
against
the
swift
evolution
microbial
resistance.
Therefore,
there
is
an
urgent
need
develop
novel
with
mechanisms
distinct
from
those
existing
antibiotics.
Nanozybiotics,
which
nanozyme-based
antimicrobials,
mimic
catalytic
action
lysosomal
enzymes
in
innate
immune
cells
kill
infectious
pathogens.
This
review
reinforces
concept
nanozymes
provides
comprehensive
summary
recent
research
advancements
on
potential
candidates.
Initially,
nanozybiotics
categorized
based
their
activities,
mimicking
either
oxidoreductase-like
or
hydrolase-like
functions,
thereby
highlighting
superior
combating
then
discusses
progress
treating
infections,
confirming
as
translational
nanozybiotic-based
products,
including
hydrogels,
nanorobots,
sprays,
bandages,
masks,
protective
clothing,
also
considered.
Finally,
current
challenges
future
prospects
nanozybiotic-related
products
explored,
emphasizing
design
capabilities
for
applications.
iScience,
Journal Year:
2025,
Volume and Issue:
28(2), P. 111763 - 111763
Published: Jan. 7, 2025
Recent
years
have
witnessed
tremendous
advances
in
wearable
sensors,
which
play
an
essential
role
personalized
healthcare
for
their
ability
real-time
sensing
and
detection
of
human
health
information.
Nanozymes,
capable
mimicking
the
functions
natural
enzymes
addressing
limitations,
possess
unique
advantages
such
as
structural
stability,
low
cost,
ease
mass
production,
making
them
particularly
beneficial
constructing
recognition
units
biosensors.
In
this
review,
we
aim
to
delineate
latest
advancements
nanozymes
development
biosensors,
focusing
on
key
developments
nanozyme
immobilization
strategies,
technologies,
biomedical
applications.
The
review
also
highlights
current
challenges
future
perspectives.
Ultimately,
it
aims
provide
insights
research
endeavors
rapidly
evolving
area.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: June 6, 2023
Microneedle
patches
have
been
extensively
employed
for
wound
healing,
while
the
lack
of
rapid
hemostasis
efficiency
and
multiple
tissue-repair
properties
restrict
their
values
in
hemorrhagic
applications.
Herein,
we
propose
a
Yunnan
Baiyao-loaded
multifunctional
microneedle
patch,
namely
(BY
+
EGF)@MN,
with
deep
tissue
penetration,
regenerative
healing.
The
EGF)@MNs
are
designed
BY-loaded
Bletilla
striata
polysaccharide
(BSP)
base
epidermal
growth
factor
(EGF)-loaded
GelMA
tips
subsequent
As
BSP
can
be
fastly
dissolved
completely
release
BY
6
min
to
promote
platelet
adhesion
activate
coagulation
system,
EGF
achieve
controlled
sustained
behavior
7
days
gradual
degradation
tips,
exhibit
strong
pro-coagulability
satisfactory
hemostatic
effect
rat
hepatic
hemorrhage
model.
Based
on
characteristics,
verified
that
when
applied
cutaneous
wounds,
proposed
MNs
accelerate
healing
process
by
enhancing
neovascularization,
fibroblast
density,
collagen
deposition.
Thus,
believe
such
promising
candidates
diverse
Smart Medicine,
Journal Year:
2023,
Volume and Issue:
2(1)
Published: Feb. 1, 2023
Abstract
With
an
ideal
comfort
level,
sensitivity,
reliability,
and
user‐friendliness,
wearable
sensors
are
making
great
contributions
to
daily
health
care,
nursing
early
disease
discovery,
body
monitoring.
Some
imparted
with
hierarchical
uneven
microstructures,
such
as
microneedle
structures,
which
not
only
facilitate
the
access
multiple
bio‐analysts
in
human
but
also
improve
abilities
detect
feeble
signals.
In
this
paper,
we
present
promising
applications
latest
progress
of
functional
microneedles
sensors.
We
begin
by
discussing
roles
sensing
units,
including
how
signals
captured,
converted,
transmitted.
introduce
microneedle‐like
structures
power
depend
on
triboelectric
or
piezoelectric
effects,
etc.
Finally,
summarize
cutting‐edge
microneedle‐based
biophysical
signal
monitoring
biochemical
analyte
detection,
provide
critical
thinking
their
future
perspectives.
