International Journal of Biological Macromolecules, Год журнала: 2023, Номер 245, С. 125528 - 125528
Опубликована: Июнь 28, 2023
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 245, С. 125528 - 125528
Опубликована: Июнь 28, 2023
Язык: Английский
Advanced Materials, Год журнала: 2023, Номер 35(48)
Опубликована: Окт. 7, 2023
Abstract Current therapeutic protocols for diabetic foot ulcers (DFUs), a severe and rapidly growing chronic complication in patients, remain nonspecific. Hyperglycemia‐caused inflammation excessive reactive oxygen species (ROS) are common obstacles encountered DFU wound healing, often leading to impaired recovery. These two effects reinforce each other, forming an endless loop. However, adequate inclusive methods still lacking target these aspects break the vicious cycle. This study proposes novel approach treating wounds, utilizing immunomodulatory hydrogel achieve self‐cascade glucose depletion ROS scavenging regulate microenvironment. Specifically, AuPt@melanin‐incorporated (GHM3) dressing is developed facilitate efficient hyperthermia‐enhanced local scavenging. Mechanistically, vitro/vivo experiments RNA sequencing analysis demonstrate that GHM3 disrupts ROS‐inflammation cascade cycle downregulates ratio of M1/M2 macrophages, consequently improving outcomes dorsal skin wounds rats. In conclusion, this proposed offers facile, safe, highly treatment modality DFUs.
Язык: Английский
Процитировано
218RSC Advances, Год журнала: 2023, Номер 13(33), С. 23087 - 23121
Опубликована: Янв. 1, 2023
Our findings revealed that the composition of constituents, reaction conditions, and synthetic processes all influence characteristics therefore applications resulting biopolymer composites.
Язык: Английский
Процитировано
82ACS Materials Letters, Год журнала: 2024, Номер 6(7), С. 2533 - 2547
Опубликована: Май 24, 2024
Contemporary options for multidrug-resistant bacteria infected diabetic foot ulcers (IDFUs) are predominantly nonspecific. These IDFU injuries often display prolonged inflammation and delayed tissue repair, mainly attributed to an overabundance of M1 macrophages in the hostile microenvironment. Although immunomodulatory hydrogels show promise IDFU-focused care, a targeted, safe transition from M2 using simplified techniques remains significant obstacle. Here, we introduce hybrid hydrogel (GGG) with inherent capabilities IDFUs. GGG is composed interpenetrating polymer networks featuring gallium-induced self-assembling glycyrrhizic acid photo-cross-linked gelatin methacryloyl matrix. Importantly, effectively decreases ratio conditions drug-resistant by disrupting iron metabolism scavenging reactive oxygen species, which contributes enhanced treatment results wounds. To sum up, strategy present provides straightforward, safe, highly effective therapeutic avenue managing
Язык: Английский
Процитировано
73Chemical Engineering Journal, Год журнала: 2024, Номер 484, С. 149493 - 149493
Опубликована: Фев. 10, 2024
Язык: Английский
Процитировано
62International Journal of Biological Macromolecules, Год журнала: 2023, Номер 244, С. 125454 - 125454
Опубликована: Июнь 16, 2023
Язык: Английский
Процитировано
58Chemical Engineering Journal, Год журнала: 2023, Номер 470, С. 144266 - 144266
Опубликована: Июнь 20, 2023
Clinical treatment of chronic wounds, particularly those prone to relapse, has been hampered by the regeneration, infection complications, and malignant transformation disordered tissue adhesions. At surface intestinal endothelial, human defensins self-assemble into higher-order nanonets that defend host cells, fight inflammation promote wound healing. Inspired this antimicrobial nanostructured network, we herein attempted construct an nanonet with hemostatic function integrated as dressing. Aiding molecular docking dynamics analysis, designed a nanogel called ACFP, which was constructed spontaneously assembling two RADA16-based hydrogelators one θ-defensin-derived peptide motif. As expected, ACFP possesses properties derived from structure defensin, well ability prevent bleeding effectively injectable biocompatible hydrogel, successfully treated epidermal wounds associated multiple bacterial infections, promoted healing complicated intraperitoneal involving cecum adjacent abdominal walls while preventing adhesion. In addition providing comprehensive therapeutic approach tremendous clinical potential for therapy, may encourage development biomimetic hydrogels functions against wide range diseases.
Язык: Английский
Процитировано
57Chemical Engineering Journal, Год журнала: 2023, Номер 471, С. 144649 - 144649
Опубликована: Июль 13, 2023
Язык: Английский
Процитировано
57International Journal of Biological Macromolecules, Год журнала: 2023, Номер 248, С. 125949 - 125949
Опубликована: Июль 24, 2023
Язык: Английский
Процитировано
50Carbohydrate Polymers, Год журнала: 2024, Номер 334, С. 122064 - 122064
Опубликована: Март 15, 2024
Язык: Английский
Процитировано
33Journal of Controlled Release, Год журнала: 2024, Номер 370, С. 543 - 555
Опубликована: Май 11, 2024
Язык: Английский
Процитировано
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