Altered Composition of Gut Microbiota in Depression: A Systematic Review

Frontiers in Psychiatry, Год журнала: 2020, Номер 11

Опубликована: Июнь 10, 2020

Cumulative evidence shows a linkage between gut microbiota pattern and depression through the brain-gut microbiome axis. The aim of this systematic review was to identify alterations patterns in people with compared healthy controls. A comprehensive literature search human studies, published January 2000 June 2019, reviewed. key words included gastrointestinal microbiome, microbiota, depression, depressive symptoms, disorder. adhered Preferred Reporting Items for Systematic Reviews Meta-Analysis (PRISMA) guidelines. Nine articles met eligibility criteria. Disparities α-diversity β-diversity existed At phylum level, there were inconsistencies abundance Firmicutes, Bacteroidetes, Proteobacteria. However, high Actinobacteria Fusobacteria phyla observed depression. On family Actinomycineae, Coriobacterineae, Bifidobacteriaceae, Clostridiales incertae sedis XI, Porphyromonadaceae, Clostridiaceae, Lactobacillaceae, Streptococcaceae, Eubacteriaceae, Thermoanaerobacteriaceae, Fusobacteriaceae, Nocardiaceae, Streptomycetaceae, low Veillonellaceae, Prevotellaceae, Bacteroidaceae, Sutterellaceae, Oscillospiraceae, Marniabilaceae, Chitinophagaceae genus Oscillibacter, Blautia, Holdemania, Clostridium XIX, Anaerostipes, Anaerofilum, Streptococcus, Gelria, Turicibacter, Parabacteroides, Eggerthella, Klebsiella, Paraprevotella, Veillonella, IV, Erysipelotrichaceae sedis, Eubacterium, Parvimonas, Desulfovibrio, Parasutterella, Actinomyces, Asaccharobacter, Atopobium, Olsenella Coprococcus, Lactobacillus, Escherichia/Shigella, XlVa, Dialister, Howardella, Pyramidobacter, Sutterella found Alteration evident Further is warranted allow translation findings toward innovative clinical strategies that may improve treatment outcomes

Язык: Английский

---

Gut microbiota and major depressive disorder: A systematic review and meta-analysis

Journal of Affective Disorders, Год журнала: 2020, Номер 266, С. 1 - 13

Опубликована: Янв. 24, 2020

Язык: Английский

---

Gut-Brain Psychology: Rethinking Psychology From the Microbiota–Gut–Brain Axis

Frontiers in Integrative Neuroscience, Год журнала: 2018, Номер 12

Опубликована: Сен. 11, 2018

Mental disorders and neurological diseases have brought rapidly increasing medical burdens. Although extensive researches been conducted hugely, effective therapies still progressing slowly. Current dilemma reminds us that the human is a superorganism. Only if we take self its partner microbiota into consideration at same time can better understand these diseases. Over last few centuries, has experienced tremendous changes much more than own genes because of modern transformations in diet, lifestyle, care, so on, paralleling epidemiological transition. Existing research indicates gut plays an important role this According to gut–brain psychology, crucial part gut–brain, it communicates with brain via microbiota–gut–brain axis. The almost develops synchronously brain, mind. Gut influences various normal mental processes phenomena they are involved pathophysiology numerous Targeting therapy for promising approach supported by three theories: hypothesis, "old friend" leaky theory. effects behavior fulfilled through microbiota-gut-brain axis which mainly composed nervous pathway, endocrine immune pathway. Undoubtedly, psychology will bring great enhancement neuroscience, psychiatry. Various improving methods including FMT, probiotics, prebiotics, healthy lifestyle shown capability promote function brain. Harnessing improve health, prevent related be true future.

Язык: Английский

---

The cellular and molecular basis of major depressive disorder: towards a unified model for understanding clinical depression

Molecular Biology Reports, Год журнала: 2019, Номер 47(1), С. 753 - 770

Опубликована: Окт. 14, 2019

Язык: Английский

---

You’ve got male: Sex and the microbiota-gut-brain axis across the lifespan

Frontiers in Neuroendocrinology, Год журнала: 2019, Номер 56, С. 100815 - 100815

Опубликована: Дек. 2, 2019

Язык: Английский

---

Guts Imbalance Imbalances the Brain: A Review of Gut Microbiota Association With Neurological and Psychiatric Disorders

Frontiers in Medicine, Год журнала: 2022, Номер 9

Опубликована: Март 31, 2022

Over the last 10 years, there has been a growing interest in relationship between gut microbiota, brain, and neurologic-associated affections. As multiple preclinical clinical research studies highlight microbiota’s potential to modulate general state of health state, it goes without saying that microbiota plays significant role neurogenesis, mental cognitive development, emotions, behaviors, progression neuropsychiatric illnesses. Gut produces important biologic products that, through gut-brain axis, are directly connected with appearance evolution neurological psychiatric disorders such as depression, anxiety, bipolar disorder, autism, schizophrenia, Parkinson’s disease, Alzheimer’s dementia, sclerosis, epilepsy. This study reviews recent on link microbiome’s shaping development most common Moreover, special attention is paid use probiotic formulations non-invasive therapeutic opportunity for prevention management neuropsychiatric-associated

Язык: Английский

---

Microbiota alterations in proline metabolism impact depression

Cell Metabolism, Год журнала: 2022, Номер 34(5), С. 681 - 701.e10

Опубликована: Май 1, 2022

The microbiota-gut-brain axis has emerged as a novel target in depression, disorder with low treatment efficacy. However, the field is dominated by underpowered studies focusing on major depression not addressing microbiome functionality, compositional nature, or confounding factors. We applied multi-omics approach combining pre-clinical models three human cohorts including patients mild depression. Microbial functions and metabolites converging onto glutamate/GABA metabolism, particularly proline, were linked to High proline consumption was dietary factor strongest impact Whole-brain dynamics revealed rich club network disruptions associated circulating proline. Proline supplementation mice exacerbated along microbial translocation. Human microbiota transplantation induced an emotionally impaired phenotype alterations GABA-, proline-, extracellular matrix-related prefrontal cortex genes. RNAi-mediated knockdown of GABA transporters Drosophila mono-association L. plantarum, high producer, conferred protection against depression-like states. Targeting may open new windows for efficient treatment.

Язык: Английский

---

Overlapping Mechanisms of Action of Brain-Active Bacteria and Bacterial Metabolites in the Pathogenesis of Common Brain Diseases

Nutrients, Год журнала: 2022, Номер 14(13), С. 2661 - 2661

Опубликована: Июнь 27, 2022

The involvement of the gut microbiota and metabolites colon-residing bacteria in brain disease pathogenesis has been covered a growing number studies, but comparative literature is scarce. To fill this gap, we explored contribution microbiota-gut-brain axis to pathophysiology seven brain-related diseases (attention deficit hyperactivity disorder, autism spectrum schizophrenia, Alzheimer's disease, Parkinson's major depressive bipolar disorder). In article, discussed changes bacterial abundance metabolic implications these on development progression. Our central findings indicate that, mechanistically, all are associated with leaky gut, neuroinflammation, over-activated microglial cells, which gut-residing their important contributors. Patients show pro-inflammatory shift colon microbiota, harbouring more Gram-negative containing immune-triggering lipopolysaccharides (LPS) cell walls. addition, properties (

Язык: Английский

---

Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors

Viruses, Год журнала: 2023, Номер 15(1), С. 175 - 175

Опубликована: Янв. 7, 2023

The clinical course and outcome of COVID-19 are highly variable, ranging from asymptomatic infections to severe disease death. Understanding the risk factors is relevant both in setting at epidemiological level. Here, we provide an overview host, viral environmental that have been shown or (in some cases) hypothesized be associated with outcomes. considered detail include age frailty, genetic polymorphisms, biological sex (and pregnancy), co- superinfections, non-communicable comorbidities, immunological history, microbiota, lifestyle patient; variation infecting dose; socioeconomic factors; air pollution. For each category, compile (sometimes conflicting) evidence for association factor outcomes (including strength effect) outline possible action mechanisms. We also discuss complex interactions between various factors.

Язык: Английский

---

The Role of Diet as a Modulator of the Inflammatory Process in the Neurological Diseases

Nutrients, Год журнала: 2023, Номер 15(6), С. 1436 - 1436

Опубликована: Март 16, 2023

Neurological diseases are recognized as major causes of disability and mortality worldwide. Due to the dynamic progress such Alzheimer’s disease (AD), Parkinson’s Disease (PD), Schizophrenia, Depression, Multiple Sclerosis (MD), scientists mobilized look for new more effective methods interventions. A growing body evidence suggests that inflammatory processes an imbalance in composition function gut microbiome, which play a critical role pathogenesis various neurological dietary interventions, Mediterranean diet DASH diet, or ketogenic can have beneficial effects on their course. The aim this review was take closer at its ingredients modulating inflammation associated with development and/or progression central nervous system diseases. Presented data shows consuming abundant fruits, vegetables, nuts, herbs, spices, legumes sources anti-inflammatory elements omega-3 fatty acids, polyphenols, vitamins, essential minerals, probiotics while avoiding foods promote inflammation, create positive brain environment is reduced risk Personalized nutritional interventions may constitute non-invasive strategy combating disorders.

Язык: Английский

---