Radiotherapy
is
crucial
in
local
cancer
management
and
needs
advancements.
Tumor
cells
elevate
intracellular
copper
levels
to
promote
growth
resist
radiation;
thus,
targeted
delivery
mitochondria
could
enhance
radiotherapy
by
inducing
cuproptosis
tumor
cells.
In
this
study,
we
engineered
a
multifunctional
nanoliposome
complex,
termed
Lipo-Ele@CuO2,
which
encapsulates
both
peroxide
(CuO2)
the
chelator
elesclomol,
can
Cu
ions
mitochondria.
The
Lipo-Ele@CuO2
complex
induces
mitochondria-mediated
synergistically
enhances
efficacy
of
radiotherapy.
CuO2
acts
as
donor
exhibits
inherent
sensitivity
acidic
environments.
Additionally,
it
depletes
glutathione,
thereby
sensitizing
cuproptosis.
Leveraging
its
pH-responsive
properties
microenvironment,
facilitate
controlled
release
efficiently
delivering
at
sites.
combined
vitro
vivo
studies
demonstrate
that
Lipo-Ele@CuO2-based
therapy
significantly
improves
antitumor
excellent
safety
profiles,
effectively
boosting
effectiveness
Furthermore,
metabolomic
transcriptomic
analyses
reveal
combination
precipitates
significant
alterations
energy
metabolism,
notably
repressing
genes
related
iron-sulfur
cluster
assembly
glycolysis,
confirming
induction
This
therapeutic
strategy
provides
viable
approach
for
addressing
clinical
resistance
demonstrates
translational
potential.
Molecules,
Год журнала:
2025,
Номер
30(3), С. 505 - 505
Опубликована: Янв. 23, 2025
Zearalenone
(ZEA)
is
one
of
the
common
mycotoxins
in
feeds.
ZEA
and
its
metabolites
have
estrogen-like
activity
can
competitively
bind
to
estrogen
receptors,
causing
reproductive
dysfunction
damage
organs.
The
toxicity
mechanism
mainly
inhibits
antioxidant
pathway
enzyme
activity,
induces
cell
cycle
arrest
DNA
damage,
blocks
process
cellular
autophagy
produce
toxic
effects.
In
animal
husbandry
practice,
when
animals
ingest
ZEA-contaminated
feed,
it
likely
lead
abortion
females,
abnormal
sperm
viability
males
with
inflammatory
reactions
various
organs,
cancerous
changes
organs
humans
they
contaminated
products.
this
paper,
we
reviewed
detail
how
oxidative
by
inducing
generation
reactive
oxygen
species
(ROS)
regulating
expression
genes
related
pathways,
germ
apoptosis
through
mitochondrial
death
receptor
activates
order
induce
autophagy.
addition,
molecular
detoxification
also
explored
aiming
provide
a
new
direction
theoretical
basis
for
development
methods
better
reduce
global
pollution
harm
caused
ZEA.
Cell,
Год журнала:
2024,
Номер
187(11), С. 2785 - 2800.e16
Опубликована: Апрель 23, 2024
Natural
cell
death
pathways
such
as
apoptosis
and
pyroptosis
play
dual
roles:
they
eliminate
harmful
cells
modulate
the
immune
system
by
dampening
or
stimulating
inflammation.
Synthetic
protein
circuits
capable
of
triggering
specific
programs
in
target
could
similarly
remove
while
appropriately
modulating
responses.
However,
actively
influence
their
modes
response
to
natural
signals,
making
it
challenging
control
modes.
Here,
we
introduce
naturally
inspired
"synpoptosis"
that
proteolytically
regulate
engineered
executioner
proteins
mammalian
death.
These
direct
modes,
respond
combinations
protease
inputs,
selectively
cells.
Furthermore,
synpoptosis
can
be
transmitted
intercellularly,
offering
a
foundation
for
engineering
synthetic
killer
induce
desired
without
self-destruction.
Together,
these
results
lay
groundwork
programmable
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 1, 2024
Pyroptosis,
a
form
of
caspase-1-dependent
cell
death,
also
known
as
inflammation-dependent
plays
crucial
role
in
diseases
such
stroke,
heart
disease,
or
tumors.
Since
its
elucidation,
pyroptosis
has
attracted
widespread
attention
from
various
sectors.
Reactive
oxygen
species
(ROS)
can
regulate
numerous
cellular
signaling
pathways.
Through
further
research
on
ROS
and
pyroptosis,
the
level
been
revealed
to
be
pivotal
for
occurrence
establishing
close
relationship
between
two.
This
review
primarily
focuses
molecular
mechanisms
tumors
inflammatory
diseases,
exploring
key
proteins
that
may
serve
drug
targets
linking
emerging
fields
targeting
pyroptosis.
Additionally,
potential
future
development
compounds
influence
ROS-regulated
is
anticipated,
aiming
provide
insights
anti-tumor
anti-inflammatory
drugs.
Science Immunology,
Год журнала:
2024,
Номер
9(97)
Опубликована: Июль 12, 2024
Virus-induced
cell
death
is
a
key
contributor
to
COVID-19
pathology.
Cell
induced
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
well
studied
in
myeloid
cells
but
less
its
primary
host
type,
angiotensin-converting
enzyme
(ACE2)–expressing
human
airway
epithelia
(HAE).
SARS-CoV-2
induces
apoptosis,
necroptosis,
and
pyroptosis
HAE
organotypic
cultures.
Single-cell
limiting-dilution
analysis
revealed
that
necroptosis
the
event
infected
cells,
whereas
uninfected
bystanders
undergo
occurs
later
during
infection.
Mechanistically,
viral
Z-RNA
binding
Z-DNA–binding
protein
1
(ZBP1)
lung
tissues
from
patients
with
COVID-19.
The
Delta
(B.1.617.2)
variant,
which
causes
more
disease
than
Omicron
(B1.1.529)
humans,
associated
orders
of
magnitude–greater
Z-RNA/ZBP1
interactions,
severity
animal
models.
Thus,
robust
ZBP1-mediated
severity.
Redox Biology,
Год журнала:
2024,
Номер
76, С. 103321 - 103321
Опубликована: Авг. 19, 2024
Cell
death
constitutes
a
critical
component
of
the
pathophysiology
cardiovascular
diseases.
A
growing
array
non-apoptotic
forms
regulated
cell
(RCD)-such
as
necroptosis,
ferroptosis,
pyroptosis,
and
cuproptosis-has
been
identified
is
intimately
linked
to
various
conditions.
These
RCD
are
governed
by
genetically
programmed
mechanisms
within
cell,
with
epigenetic
modifications
being
common
crucial
regulatory
method.
Such
include
DNA
methylation,
RNA
histone
acetylation,
non-coding
RNAs.
This
review
recaps
roles
modifications,
RNAs
in
diseases,
well
which
regulate
key
proteins
involved
death.
Furthermore,
we
systematically
catalog
existing
pharmacological
agents
targeting
novel
their
action
article
aims
underscore
pivotal
role
precisely
regulating
specific
pathways
thus
offering
potential
new
therapeutic
avenues
that
may
prove
more
effective
safer
than
traditional
treatments.
Abstract
The
gut
microbiota
plays
a
critical
role
in
maintaining
human
health,
influencing
wide
range
of
physiological
processes,
including
immune
regulation,
metabolism,
and
neurological
function.
Recent
studies
have
shown
that
imbalances
composition
can
contribute
to
the
onset
progression
various
diseases,
such
as
metabolic
disorders
(e.g.,
obesity
diabetes)
neurodegenerative
conditions
Alzheimer's
Parkinson's).
These
are
often
accompanied
by
chronic
inflammation
dysregulated
responses,
which
closely
linked
specific
forms
cell
death,
pyroptosis
ferroptosis.
Pathogenic
bacteria
trigger
these
death
pathways
through
toxin
release,
while
probiotics
been
found
mitigate
effects
modulating
responses.
Despite
insights,
precise
mechanisms
influences
diseases
remain
insufficiently
understood.
This
review
consolidates
recent
findings
on
impact
immune‐mediated
inflammation‐associated
conditions.
It
also
identifies
gaps
current
research
explores
potential
advanced
technologies,
organ‐on‐chip
models
microbiome–gut–organ
axis,
for
deepening
our
understanding.
Emerging
tools,
single‐bacterium
omics
spatial
metabolomics,
discussed
their
promise
elucidating
microbiota's
disease
development.
Stem Cell Research & Therapy,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июль 23, 2024
Abstract
With
the
widespread
application
of
nuclear
technology
across
various
fields,
ionizing
radiation-induced
injuries
are
becoming
increasingly
common.
The
bone
marrow
(BM)
hematopoietic
tissue
is
a
primary
target
organ
radiation
injury.
Recent
researches
have
confirmed
that
dysfunction
mainly
results
from
BM
stem
cells
(HSCs)
Additionally,
disrupting
and
reshaping
microenvironment
critical
factor
impacting
both
injury
regeneration
HSCs
post
radiation.
However,
regulatory
mechanisms
to
their
remain
poorly
understood,
prevention
treatment
focus
difficulty
in
medicine
research.
In
this
review,
we
aim
summarize
effects
microenvironment,
thereby
enhancing
our
understanding
providing
insights
for
its
future.
