Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

Science, Год журнала: 2018, Номер 360(6396)

Опубликована: Май 31, 2018

Imaging dopamine release in the brain Neuromodulator alters function of target circuits poorly known ways. An essential step to address this knowledge gap is measure dynamics neuromodulatory signals while simultaneously manipulating elements circuit during behavior. Patriarchi et al. developed fluorescent protein–based indicators visualize spatial and temporal directly with high fidelity resolution. In cortex, two-photon imaging these was used map activity at cellular Science , issue p. eaat4422

Язык: Английский

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The basal ganglia and the cerebellum: nodes in an integrated network

Nature reviews. Neuroscience, Год журнала: 2018, Номер 19(6), С. 338 - 350

Опубликована: Апрель 11, 2018

Язык: Английский

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What, If, and When to Move: Basal Ganglia Circuits and Self-Paced Action Initiation

Annual Review of Neuroscience, Год журнала: 2019, Номер 42(1), С. 459 - 483

Опубликована: Апрель 24, 2019

Deciding what to do and when move is vital our survival. Clinical fundamental studies have identified basal ganglia circuits as critical for this process. The main input nucleus of the ganglia, striatum, receives inputs from frontal, sensory, motor cortices interconnected thalamic areas that provide information about potential goals, context, actions directly or indirectly modulates outputs. striatum also dopaminergic can signal reward prediction errors behavioral transitions movement initiation. Here we review models how direct indirect pathways modulate outputs facilitate initiation, discuss role cortical in determining if it. Complex but exciting scenarios emerge shed new light on self-paced

Язык: Английский

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The Spatiotemporal Organization of the Striatum Encodes Action Space

Neuron, Год журнала: 2017, Номер 95(5), С. 1171 - 1180.e7

Опубликована: Авг. 1, 2017

Язык: Английский

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The Spatiotemporal Organization of the Striatum Encodes Action Space

Neuron, Год журнала: 2017, Номер 96(4), С. 949 - 949

Опубликована: Ноя. 1, 2017

Язык: Английский

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The Basal Ganglia Do Not Select Reach Targets but Control the Urgency of Commitment

Neuron, Год журнала: 2017, Номер 95(5), С. 1160 - 1170.e5

Опубликована: Авг. 1, 2017

Язык: Английский

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Midbrain Dopamine Neurons Signal Belief in Choice Accuracy during a Perceptual Decision

Current Biology, Год журнала: 2017, Номер 27(6), С. 821 - 832

Опубликована: Март 1, 2017

Язык: Английский

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The role of dopamine in the brain - lessons learned from Parkinson's disease

NeuroImage, Год журнала: 2018, Номер 190, С. 79 - 93

Опубликована: Ноя. 20, 2018

Parkinson's disease causes a characteristic combination of motor symptoms due to progressive neurodegeneration dopaminergic neurons in the substantia nigra pars compacta. The core impairment neurotransmission has motivated use functional magnetic resonance imaging (fMRI) patients with elucidate role dopamine control and cognition humans. Here we review main insights from brain disease. Task-related fMRI revealed many disease-related alterations activation patterns. However, interpretation these findings is complicated by fact that task-dependent activity influenced complex interactions between amount task-relevant nuclei, state medication, genetic factors performance. Despite ambiguities, studies demonstrated central generation movement vigour (bradykinesia) excessive movements (dyskinesia), involving changes both connectivity putamen, premotor regions, right inferior frontal gyrus (rIFG). addressing cognitive flexibility provided convergent evidence for non-linear, U-shaped, relationship levels nuclei pharmacological replacement can therefore move performance either away or towards task-specific optimum. Dopamine also strongly affect processing reward punishment optimal learning. further are needed detailed understanding mechanisms underlying effects. • (PD) results neurons. Functional MRI examines human brain. Evidence point securing vigour. show an inverse U-shape relationship. learning rewards punishments.

Язык: Английский

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Movement Vigor as a Reflection of Subjective Economic Utility

Trends in Neurosciences, Год журнала: 2019, Номер 42(5), С. 323 - 336

Опубликована: Март 13, 2019

Язык: Английский

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Imaging striatal dopamine release using a nongenetically encoded near infrared fluorescent catecholamine nanosensor

Science Advances, Год журнала: 2019, Номер 5(7)

Опубликована: Июль 5, 2019

A near infrared fluorescent probe enables high spatial resolution imaging of dopamine release in striatal brain tissue.

Язык: Английский

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