A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement DOI Creative Commons
Xiong Xiao, Hanfei Deng, Alessandro Furlan

et al.

Cell, Journal Year: 2020, Volume and Issue: 183(1), P. 211 - 227.e20

Published: Sept. 15, 2020

Language: Английский

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors DOI Open Access
Tommaso Patriarchi, Jounhong Ryan Cho, Katharina Merten

et al.

Science, Journal Year: 2018, Volume and Issue: 360(6396)

Published: May 31, 2018

Imaging dopamine release in the brain Neuromodulator alters function of target circuits poorly known ways. An essential step to address this knowledge gap is measure dynamics neuromodulatory signals while simultaneously manipulating elements circuit during behavior. Patriarchi et al. developed fluorescent protein–based indicators visualize spatial and temporal directly with high fidelity resolution. In cortex, two-photon imaging these was used map activity at cellular Science , issue p. eaat4422

Language: Английский

Citations

974
The basal ganglia and the cerebellum: nodes in an integrated network DOI
Andreea C. Bostan, Peter L. Strick

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(6), P. 338 - 350

Published: April 11, 2018

Language: Английский

Citations

654
What, If, and When to Move: Basal Ganglia Circuits and Self-Paced Action Initiation DOI Open Access
Andreas Klaus, Joaquim Alves da Silva, Rui M. Costa

et al.

Annual Review of Neuroscience, Journal Year: 2019, Volume and Issue: 42(1), P. 459 - 483

Published: April 24, 2019

Deciding what to do and when move is vital our survival. Clinical fundamental studies have identified basal ganglia circuits as critical for this process. The main input nucleus of the ganglia, striatum, receives inputs from frontal, sensory, motor cortices interconnected thalamic areas that provide information about potential goals, context, actions directly or indirectly modulates outputs. striatum also dopaminergic can signal reward prediction errors behavioral transitions movement initiation. Here we review models how direct indirect pathways modulate outputs facilitate initiation, discuss role cortical in determining if it. Complex but exciting scenarios emerge shed new light on self-paced

Language: Английский

Citations

258
The Spatiotemporal Organization of the Striatum Encodes Action Space DOI Creative Commons
Andreas Klaus, Gabriela J. Martins, Vítor Paixão

et al.

Neuron, Journal Year: 2017, Volume and Issue: 95(5), P. 1171 - 1180.e7

Published: Aug. 1, 2017

Language: Английский

Citations

249
The Spatiotemporal Organization of the Striatum Encodes Action Space DOI Creative Commons
Andreas Klaus, Gabriela J. Martins, Vítor Paixão

et al.

Neuron, Journal Year: 2017, Volume and Issue: 96(4), P. 949 - 949

Published: Nov. 1, 2017

Language: Английский

Citations

213
The Basal Ganglia Do Not Select Reach Targets but Control the Urgency of Commitment DOI Creative Commons
David Thura, Paul Cisek

Neuron, Journal Year: 2017, Volume and Issue: 95(5), P. 1160 - 1170.e5

Published: Aug. 1, 2017

Language: Английский

Citations

196
Midbrain Dopamine Neurons Signal Belief in Choice Accuracy during a Perceptual Decision DOI Creative Commons
Armin Lak, Kensaku Nomoto, Mehdi Keramati

et al.

Current Biology, Journal Year: 2017, Volume and Issue: 27(6), P. 821 - 832

Published: March 1, 2017

Language: Английский

Citations

187
The role of dopamine in the brain - lessons learned from Parkinson's disease DOI Creative Commons
David Meder, Damian M. Herz, James B. Rowe

et al.

NeuroImage, Journal Year: 2018, Volume and Issue: 190, P. 79 - 93

Published: Nov. 20, 2018

Parkinson's disease causes a characteristic combination of motor symptoms due to progressive neurodegeneration dopaminergic neurons in the substantia nigra pars compacta. The core impairment neurotransmission has motivated use functional magnetic resonance imaging (fMRI) patients with elucidate role dopamine control and cognition humans. Here we review main insights from brain disease. Task-related fMRI revealed many disease-related alterations activation patterns. However, interpretation these findings is complicated by fact that task-dependent activity influenced complex interactions between amount task-relevant nuclei, state medication, genetic factors performance. Despite ambiguities, studies demonstrated central generation movement vigour (bradykinesia) excessive movements (dyskinesia), involving changes both connectivity putamen, premotor regions, right inferior frontal gyrus (rIFG). addressing cognitive flexibility provided convergent evidence for non-linear, U-shaped, relationship levels nuclei pharmacological replacement can therefore move performance either away or towards task-specific optimum. Dopamine also strongly affect processing reward punishment optimal learning. further are needed detailed understanding mechanisms underlying effects. • (PD) results neurons. Functional MRI examines human brain. Evidence point securing vigour. show an inverse U-shape relationship. learning rewards punishments.

Language: Английский

Citations

172
Movement Vigor as a Reflection of Subjective Economic Utility DOI Creative Commons
Reza Shadmehr, Thomas R. Reppert, Erik M. Summerside

et al.

Trends in Neurosciences, Journal Year: 2019, Volume and Issue: 42(5), P. 323 - 336

Published: March 13, 2019

Language: Английский

Citations

159
Imaging striatal dopamine release using a nongenetically encoded near infrared fluorescent catecholamine nanosensor DOI Creative Commons
Abraham G. Beyene, Kristen Delevich, Jackson Travis Del Bonis-O’Donnell

et al.

Science Advances, Journal Year: 2019, Volume and Issue: 5(7)

Published: July 5, 2019

A near infrared fluorescent probe enables high spatial resolution imaging of dopamine release in striatal brain tissue.

Language: Английский

Citations

157