Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

Free Radical Biology and Medicine, Год журнала: 2022, Номер 184, С. 114 - 134

Опубликована: Апрель 7, 2022

Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide. It characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia induced reactive oxygen species (ROS) production oxidative stress are correlated with the pathogenesis progression of this disease. To counteract harmful effects ROS, endogenous antioxidants body or exogenous neutralise it maintain bodily homeostasis. Under hyperglycemic conditions, imbalance between cellular antioxidant system ROS results in stress, which subsequently development diabetes. These produced endoplasmic reticulum, phagocytic cells peroxisomes, mitochondrial electron transport chain (ETC) playing pivotal role. The exacerbated can directly cause structural functional modifications proteins, lipids nucleic acids. also modulates several intracellular signaling pathways that lead to impairment function. In addition, hyperglycemia-induced contributes micro- macro-vascular diabetic complications. Various in-vivo in-vitro studies have demonstrated anti-oxidative natural products their derived bioactive compounds. However, there conflicting clinical evidence on beneficial these therapies prevention. This review article focused multifaceted role caused overproduction related complications possible antioxidative therapeutic strategies targeting

Язык: Английский

---

Recent progress in the development of fluorescent probes for imaging pathological oxidative stress

Chemical Society Reviews, Год журнала: 2023, Номер 52(11), С. 3873 - 3926

Опубликована: Янв. 1, 2023

Oxidative stress is closely related to the physiopathology of numerous diseases. Reactive oxygen species (ROS), reactive nitrogen (RNS), and sulfur (RSS) are direct participants important biomarkers oxidative stress.

Язык: Английский

---

The Relevance of a Physical Active Lifestyle and Physical Fitness on Immune Defense: Mitigating Disease Burden, With Focus on COVID-19 Consequences

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Фев. 5, 2021

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a fast spreading virus leading to the development of Disease-2019 (COVID-19). and critical cases are characterized by damage respiratory system, endothelial inflammation, multiple organ failure triggered an excessive production proinflammatory cytokines, culminating in high number deaths all over world. Sedentarism induces worse, continuous, progressive consequences health. On other hand, physical activity provides benefits health improves low-grade systemic inflammation. aim this review elucidate effects fitness, immune defense, its contribution mitigate severe inflammatory response mediated SARS-CoV-2. Physical exercise effective therapeutic strategy SARS-CoV-2 infection. In sense, studies have shown that acute myokines secreted tissues into bloodstream, supporting modulatory effect. Therefore, maintaining influence balance system increases vigilance, also might promote potent against infectious diseases chronic associated with forms COVID-19. Protocols maintain practice suggested been strongly established, such as home-based (HBE) outdoor-based (OBE). regard, HBE help reduce levels inactivity, bed rest, sitting time, impacting on adherence activity, promoting related exercise, attracting patients different stages treatment for parallel, OBE must improve health, but prevent COVID-19 outcomes populations. conclusion, or models can be progress infection, coadjutant therapy at ages conditions.

Язык: Английский

---

Therapeutic Effects of Green Tea Polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis

International Journal of Molecular Sciences, Год журнала: 2022, Номер 24(1), С. 340 - 340

Опубликована: Дек. 25, 2022

(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea. Thanks to multiple interactions with cell surface receptors, intracellular signaling pathways, and nuclear transcription factors, EGCG possesses a wide variety of anti-inflammatory, antioxidant, antifibrotic, anti-remodelation, tissue-protective properties which may be useful treatment various diseases, particularly cancer, neurological, cardiovascular, respiratory, metabolic disorders. This article reviews current information on biological effects above-mentioned disorders relation molecular pathways controlling inflammation, oxidative stress, apoptosis.

Язык: Английский

---

Pancreatic β-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress

World Journal of Diabetes, Год журнала: 2023, Номер 14(3), С. 130 - 146

Опубликована: Март 15, 2023

Insulin resistance and pancreatic β-cell dysfunction are major pathological mechanisms implicated in the development progression of type 2 diabetes (T2D). Beyond detrimental effects insulin resistance, inflammation oxidative stress have emerged as critical features T2D that define dysfunction. Predominant markers such C-reactive protein, tumor necrosis factor alpha, interleukin-1β consistently associated with failure preclinical models people T2D. Similarly, important stress, increased reactive oxygen species depleted intracellular antioxidants, consistent damage conditions Such illustrate a relationship between an abnormal inflammatory response generation during The current review explores clinical research on patho-logical implications Moreover, molecular relevant biomarkers involved this process discussed to divulge link Underpinning relevance review, systematic analysis evidence from randomized controlled trials is covered, potential therapeutic some commonly used antidiabetic agents modulating makers improve function.

Язык: Английский

---

Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(9), С. 7910 - 7910

Опубликована: Апрель 26, 2023

Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from general pathology perspective, particularly with regard atherogenesis patterns in context both canonical and non-classical inflammation types. In review, we analyze various typical phenomena outcomes cellular pro-inflammatory stress atherosclerosis, as well role endothelial dysfunction local systemic manifestations low-grade inflammation. We also present features immune development productive stable unstable plaques, along their similarities differences compared There are numerous factors that act inducers inflammatory process including vascular endothelium aging, metabolic dysfunctions, autoimmune, some cases, infectious damage factors. Life-critical complications such cardiogenic shock severe strokes, associated acute hyperinflammation. Additionally, critical atherosclerotic ischemia lower extremities induces paracoagulation chronic Conversely, sepsis, other conditions, diseases contribute atherogenesis. summary, can be characterized an independent form inflammation, sharing but having fundamental variants (classic vasculitis).

Язык: Английский

---

The Influence of Lifestyle and Treatment on Oxidative Stress and Inflammation in Diabetes

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(24), С. 15743 - 15743

Опубликована: Дек. 12, 2022

Diabetes is considered a new pandemic of the modern world, and number sufferers steadily increasing. Sustained hyperglycemia promotes production free radicals leads to persistent, low-grade inflammation. Oxidative stress causes mitochondrial destruction, which along with activation hexosamine pathway, nuclear factor-κB (Nf-κb), p38 mitogen-activated protein kinase (p38 MAPK), c-jun NH2 terminal kinase/stress-activated (JNK/SAPK) or toll-like receptors (TLRs), pancreatic β-cell dysfunction. However, there also protective mechanism that counteracts oxidative inflammation in diabetes, mitophagy, autophagy. An important part strategy control diabetes lead healthy lifestyle based on, among other things, regular physical activity, giving up smoking, eating balanced diet containing ingredients antioxidant potential, including vegetables fruits, using hypoglycemic pharmacotherapy. Tobacco smoke recognized modifiable risk factor for many diseases it has been shown disease increases proportion intensity smoking. Physical activity as another component therapy can effectively reduce glucose fluctuations, high interval exercise appears have most beneficial effect. A proper not only cellular sensitivity insulin, but able stress. Pharmacotherapy affect Some oral drugs, such metformin, pioglitazone, vildagliptin, liraglutide, exenatide, cause reduction markers and/or inflammation, while drug Imeglimin reverses In studies sitagliptin, vildagliptin effects on were achieved by, reducing glycemic excursions. For insulin therapy, no corresponding correlation was observed. Insulin did parameters. There between variability patients therapy. The data used this study obtained by searching PubMed online databases, taking into account recent studies.

Язык: Английский

---

Food Polyphenols and Type II Diabetes Mellitus: Pharmacology and Mechanisms

Molecules, Год журнала: 2023, Номер 28(10), С. 3996 - 3996

Опубликована: Май 10, 2023

Type II diabetes mellitus and its related complications are growing public health problems. Many natural products present in our diet, including polyphenols, can be used treating managing type different diseases, owing to their numerous biological properties. Anthocyanins, flavonols, stilbenes, curcuminoids, hesperidin, hesperetin, naringenin, phenolic acids common polyphenols found blueberries, chokeberries, sea-buckthorn, mulberries, turmeric, citrus fruits, cereals. These compounds exhibit antidiabetic effects through pathways. Accordingly, this review presents an overview of the most recent developments using food for mellitus, along with various mechanisms. In addition, work summarizes literature about anti-diabetic effect evaluates potential as complementary or alternative medicines treat mellitus. Results obtained from survey show that anthocyanins, manage by protecting pancreatic β-cells against glucose toxicity, promoting β-cell proliferation, reducing apoptosis, inhibiting α-glucosidases α-amylase. these antioxidant anti-inflammatory activities, modulate carbohydrate lipid metabolism, optimize oxidative stress, reduce insulin resistance, stimulate pancreas secrete insulin. They also activate signaling inhibit digestive enzymes, regulate intestinal microbiota, improve adipose tissue absorption, formation advanced glycation end products. However, insufficient data available on effective mechanisms necessary diabetes.

Язык: Английский

---

Social isolation, loneliness, and incident type 2 diabetes mellitus: results from two large prospective cohorts in Europe and East Asia and Mendelian randomization

EClinicalMedicine, Год журнала: 2023, Номер 64, С. 102236 - 102236

Опубликована: Сен. 21, 2023

Язык: Английский

---

A novel machine learning approach for diagnosing diabetes with a self-explainable interface

Healthcare Analytics, Год журнала: 2024, Номер 5, С. 100301 - 100301

Опубликована: Янв. 21, 2024

This study introduces the first-ever self-explanatory interface for diagnosing diabetes patients using machine learning. We propose four classification models (Decision Tree (DT), K-nearest Neighbor (KNN), Support Vector Classification (SVC), and Extreme Gradient Boosting (XGB)) based on publicly available dataset. To elucidate inner workings of these models, we employed learning interpretation method known as Shapley Additive Explanations (SHAP). All exhibited commendable accuracy in with diabetes, XGB model showing a slight edge over others. Utilising SHAP, delved into model, providing in-depth insights reasoning behind its predictions at granular level. Subsequently, integrated SHAP's local explanations an to predict patients. serves critical role it diagnoses offers transparent decisions made, users heightened awareness their current health conditions. Given high-stakes nature medical field, this developed can be further enhanced by including more extensive clinical data, ultimately aiding professionals decision-making processes.

Язык: Английский

---