Biochimica et Biophysica Acta (BBA) - General Subjects, Год журнала: 2025, Номер unknown, С. 130821 - 130821
Опубликована: Май 1, 2025
Язык: Английский
Molecular Biomedicine, Год журнала: 2023, Номер 4(1)
Опубликована: Окт. 16, 2023
Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation lipid peroxides, provides novel avenue for delving into intersection metabolism, oxidative stress, and disease pathology. We have witnessed mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, traumatic tissue injuries. By unraveling intricate underpinnings molecular machinery, contributors, signaling conduits, regulatory networks governing researchers aim bridge gap between intricacies this unique mode multifaceted implications health disease. In light rapidly advancing landscape ferroptosis research, we present comprehensive review aiming at extensive in origins progress human diseases. This concludes careful analysis potential treatment approaches carefully designed either inhibit or promote ferroptosis. Additionally, succinctly summarized therapeutic targets compounds that hold promise targeting within various facet underscores burgeoning possibilities manipulating as strategy. summary, enriched insights both investigators practitioners, while fostering an elevated comprehension latent translational utilities. revealing basic processes investigating possibilities, crucial resource scientists medical aiding deep understanding effects situations.
Язык: Английский
Процитировано
69
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(6), С. 2581 - 2597
Опубликована: Март 11, 2024
Doxorubicin (DOX)-mediated cardiotoxicity can exacerbate mortality in oncology patients, but related pharmacotherapeutic measures are relatively limited. Ferroptosis was recently identified as a major mechanism of DOX-induced cardiotoxicity. Idebenone, novel ferroptosis inhibitor, is well-described clinical drug widely used. However, its role and pathological still unclear. In this study, we demonstrated the effects idebenone on elucidated underlying mechanism. A single intraperitoneal injection DOX (15 mg/kg) administrated to establish The results showed that significantly attenuated cardiac dysfunction due ability regulate acute Fe2+ ROS overload, which resulted ferroptosis. CESTA BLI further revealed idebenone's anti-ferroptosis effect mediated by FSP1. Interestingly, increased FSP1 protein levels did not affect Fsp1 mRNA presence DOX. Idebenone could form stable hydrogen bonds with at K355, may influence association ubiquitin. confirmed stabilized inhibiting ubiquitination degradation. conclusion, study demonstrates via regulation FSP1, making it potential for patients receiving treatment.
Язык: Английский
Процитировано
22
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 170, С. 116057 - 116057
Опубликована: Дек. 29, 2023
In the 21st century, cardiovascular disease (CVD) has become one of leading causes death worldwide. The prevention and treatment CVD remain pressing scientific issues. Several recent studies have suggested that ferroptosis may play a key role in CVD. Most conducted thus far on supported link. Ferroptosis mediated by different signaling metabolic pathways can lead to ischemic heart disease, myocarditis, failure, ischemia-reperfusion injury, cardiomyopathy. Still, specific mechanism CVD, particular organ areas affected, stage involved need be further studied. Therefore, understanding mechanisms regulating improve management. Throughout this review, we summarized its effect pathogenesis We also predicted discussed future research directions, aiming provide new ideas strategies for preventing treating
Язык: Английский
Процитировано
24
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 897 - 897
Опубликована: Янв. 11, 2024
The hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI) is about 6% and has not decreased recent years. leading cause of death these ischemia/reperfusion (I/R) cardiac injury. It quite obvious that there an urgent need to create new drugs for the treatment STEMI based on knowledge pathogenesis I/R injury, particular, molecular mechanism ferroptosis. In this study, it was demonstrated ferroptosis involved development antitumor drug-induced cardiomyopathy, diabetic septic inflammation. There indirect evidence participates stress-induced activation AMPK, PKC, ERK1/2, PI3K, Akt prevents inhibition HO-1 alleviates roles GSK-3β NOS regulation require further study. stimulation Nrf2, STAT3 TLR4 NF-κB promotes cardiomyocytes. MiR-450b-5p miR-210-3p can increase tolerance cardiomyocytes hypoxia/reoxygenation through Circ_0091761 RNA, miR-214-3p, miR-199a-5p, miR-208a/b, miR-375-3p, miR-26b-5p miR-15a-5p aggravate
Язык: Английский
Процитировано
14
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Фев. 26, 2024
Ginsenoside Rg3, a compound derived from
Язык: Английский
Процитировано
9
APOPTOSIS, Год журнала: 2025, Номер unknown
Опубликована: Янв. 20, 2025
Язык: Английский
Процитировано
1
Biomedicines, Год журнала: 2023, Номер 11(5), С. 1500 - 1500
Опубликована: Май 22, 2023
Mitochondria are the main site of intracellular synthesis ATP, which provides energy for various physiological activities cell. Cardiomyocytes have a high density mitochondria and mitochondrial damage is present in variety cardiovascular diseases. In this paper, we describe cardiomyopathy, congenital heart disease, coronary myocardial ischemia-reperfusion injury, failure, drug-induced cardiotoxicity, context key roles cardiac development homeostasis. Finally, discuss current therapeutic strategies aimed at alleviating impairment-related dysfunction, including pharmacological strategies, gene therapy, replacement transplantation. It hoped that will provide new ideas treatment
Язык: Английский
Процитировано
17
Journal of Cellular and Molecular Medicine, Год журнала: 2023, Номер 27(14), С. 1988 - 2003
Опубликована: Май 27, 2023
As one of the most prevalent heritable cardiovascular diseases, dilated cardiomyopathy (DCM) induces cardiac insufficiency and dysfunction. Although genetic mutation has been identified causes DCM, usage biomarkers such as RNAs for DCM early diagnosis is still being overlooked. In addition, alternation could reflect progression an indicator prognosis patients. Therefore, it beneficial to develop based diagnostic tool DCM. are often unstable within circulatory system, leading infeasibility clinical application. Recently discovered exosomal miRNAs have stability that then need purpose. Hence, fully understanding miRNA patients vital translation. this study, we employed next generation sequencing on plasma comprehensively characterize expression in exosomes from exhibiting chronic heart failure (CHF) compared healthy individuals. A complex landscape differential target genes with CHF were identified. More importantly, 92 differentially expressed undergoing correlated several enriched pathways, including oxytocin signalling pathway, circadian entrainment, hippo pathway-multiple species, ras pathway morphine addiction. This study reveals profiles CHF, further reveal their potential roles pathogenesis it, presenting a new direction management CHF.
Язык: Английский
Процитировано
17
Cancer Letters, Год журнала: 2024, Номер 590, С. 216823 - 216823
Опубликована: Март 21, 2024
Язык: Английский
Процитировано
8
Aging, Год журнала: 2024, Номер 16(4), С. 3856 - 3879
Опубликована: Фев. 16, 2024
Aging | doi:10.18632/aging.205564. Shiqian Zhang, Ge Wenxiu Wang, Song-Bin Guo, Pengpeng Fuqi Quanbo Zhou, Zhaokai Yujia Haifeng Sun, Wenming Cui, Shuaixi Yang, Weitang Yuan
Процитировано
5