International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 137144 - 137144
Опубликована: Ноя. 1, 2024
Язык: Английский
Bioactive Materials, Год журнала: 2024, Номер 34, С. 494 - 519
Опубликована: Янв. 21, 2024
Biomaterial choice is an essential step during the development tissue engineering and regenerative medicine (TERM) applications. The selected biomaterial must present properties allowing physiological-like recapitulation of several processes that lead to reestablishment homeostatic or organ function. Biomaterials derived from extracellular matrix (ECM) many such their use in field has been steadily increasing. Considering this growing importance, it becomes imperative provide a comprehensive overview ECM biomaterials, encompassing sourcing, processing, integration into TERM This review compiles main strategies used isolate process ECM-derived biomaterials as well different techniques for its characterization, namely biochemical chemical, physical, morphological, biological. Lastly, some applications are explored discussed.
Язык: Английский
Процитировано
31
Bioactive Materials, Год журнала: 2024, Номер 38, С. 346 - 373
Опубликована: Май 9, 2024
Gelatin methacryloyl (GelMA) hydrogels is a widely used bioink because of its good biological properties and tunable physicochemical properties, which has been in variety tissue engineering regeneration. However, pure GelMA limited by the weak mechanical strength lack continuous osteogenic induction environment, difficult to meet needs bone repair. Moreover, are unable respond complex stimuli therefore adapt physiological pathological microenvironments. This review focused on functionalization strategies hydrogel based bioinks for The synthesis process was described details, various functional methods requirements regeneration, including strength, porosity, vascularization, differentiation, immunoregulation patient specific repair, etc. In addition, response smart GelMA-based external physical stimulation internal microenvironment stimulation, as well achieve both disease treatment regeneration presence common diseases (such inflammation, infection, tumor) also briefly reviewed. Finally, we emphasized current challenges possible exploration directions
Язык: Английский
Процитировано
30
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(12)
Опубликована: Янв. 31, 2024
Abstract The skin serves as the body's outermost barrier and is largest organ, providing protection not only to body but also various internal organs. Owing continuous exposure external factors, it susceptible damage that can range from simple severe, including serious types of wounds such burns or chronic wounds. Macrophages play a crucial role in entire wound‐healing process contribute significantly regeneration. Initially, M1 macrophages infiltrate phagocytose bacteria, debris, dead cells fresh As tissue repair activated, M2 are promoted, reducing inflammation facilitating restoration dermis epidermis regenerate tissue. This suggests extracellular matrix (ECM) promotes cell adhesion, proliferation, migrationand macrophage polarization. Among numerous strategies, electrospinning versatile technique for obtaining ECM‐mimicking structures with anisotropic isotropic topologies micro/nanofibers. Various electrospun biomaterials influence polarization based on their topologies. Moreover, these fibers possess high surface‐area‐to‐volume ratio, promoting effective exchange vital nutrients oxygen, which viability Micro/nanofibers diverse physical chemical properties be tailored polarize toward regeneration wound healing, depending specific requirements. review describes significance micro/nanostructures activating healing.
Язык: Английский
Процитировано
20
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 246, С. 125672 - 125672
Опубликована: Июль 3, 2023
Язык: Английский
Процитировано
39
Engineered Regeneration, Год журнала: 2023, Номер 5(1), С. 21 - 44
Опубликована: Окт. 27, 2023
Bone fractures are common occurrence in clinical settings, creating a high demand for effective repair material. Unfortunately, limited graft availability, donor site morbidities, unpredictable outcomes, immunologic reactions, infection risks, and geometrical mismatching concerns hampered tissue use underscored the need scaffolds more bone reconstructions due to their tunable properties. Significant progress has been carried out past decade fields of nanoceramics synthesis, bioconjugate chemistry, composite material processing. This review outlines hierarchical structures biology tissue, materialistic components (bioceramics, polymers, bioactive drugs), featured scaffolding strategies (nanofibers, hydrogels, aerogels, bioprinting, fiber-reinforced composite), emphasis that physiochemical characteristics should be used as an inspiration scaffold design. discussed how differences materiobiological aspects scaffolds, such polymer/bioceramic nanocomposite, mineralized matrix-rich 3D microenvironmental cues, pore space mechanical usage physical stimulation (magnetic, electroactive, photoactivated cues), surface cues (wettability, roughness, textured, charge), biointerface (cell–biomaterial interactions, cell-selective homing, cell regulatory strategies) modulate cellular biological response engineering. study further challenges benefits integrating
Язык: Английский
Процитировано
30
Journal of Controlled Release, Год журнала: 2024, Номер 368, С. 24 - 41
Опубликована: Фев. 21, 2024
Язык: Английский
Процитировано
8
Advanced Materials, Год журнала: 2024, Номер 36(24)
Опубликована: Фев. 27, 2024
Contamination tolerance and long-term mechanical support are the two critical properties of meshes for contaminated abdominal wall defect repair. However, biological with excellent pollution fail to provide bio-adaptive due their rapid degradation. Here, a novel double-layer asymmetric porous mesh (SIS/PVA-EXO) is designed by simple efficient in situ freeze-thaw sticky polyvinyl alcohol (PVA) solution on loosely surface small intestinal submucosal decellularized matrix (SIS), which can successfully repair dynamic through only single-stage surgery. The exosome-loaded degradable SIS layer accelerates tissue healing; meanwhile, densely PVA maintain without any adhesion. In addition, tensile strength strain at break SIS/PVA-EXO change gradually from 0.37 MPa 210% 0.10 385% degradation layer. This unique performance dynamically adapt variable demands during different periods reconstruction. As result, this shows an attractive prospect treatment recurrence integrating local immune regulation, remodeling, supporting.
Язык: Английский
Процитировано
8
ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 16(1), С. 95 - 110
Опубликована: Дек. 29, 2023
Nanozymes, emerging nanomaterials for wound healing, exhibit enzyme-like activity to modulate the levels of reactive oxygen species (ROS) at sites. Yet, solo regulation endogenous ROS by nanozymes often falls short, particularly in chronic refractory wounds with complex and variable pathological microenvironments. In this study, we report development a multifunctional dressing integrating conventional alginate (Alg) hydrogel newly developed biodegradable copper hydrogen phosphate (CuP) nanozyme, which possesses good near-infrared (NIR) photothermal conversion capabilities, sustained Cu ion release ability, pH-responsive peroxidase/catalase-mimetic catalytic activity. When examining acute infected characterized low pH environment, engineered Alg/CuP composite hydrogels demonstrated high bacterial eradication efficacy against both planktonic bacteria biofilms, attributed combined action catalytically generated hydroxyl radicals ions. contrast, when applied diabetic wounds, typically have these significant angiogenic performance. This is driven provision dissolved beneficial supplement ions released from degradable CuP nanozyme. Further, mild thermal effect induced NIR irradiation amplifies activities bioactivity ions, thereby enhancing healing process wounds. Our study validates that synergistic integration effects, activity, can concurrently yield antibacterial efficiency tissue regenerative rendering it highly promising various clinical applications healing.
Язык: Английский
Процитировано
21
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(9)
Опубликована: Янв. 26, 2024
In vitro engineered skin models are emerging as an alternative platform to reduce and replace animal testing in dermatological research. Despite the progress made recent years, considerable challenges still exist for inclusion of diverse cell types within models. Blood vessels, particular, essential maintaining tissue homeostasis one many primary contributors disease inception progression. Substantial efforts past have allowed successful fabrication vascularized that currently utilized modeling drugs/cosmetics testing. This review first discusses need vascularization tissue-engineered models, highlighting their role grafting pathophysiology. Second, spotlights milestones utilization Additionally, advances including use bioreactors, organ-on-a-chip devices, organoid systems briefly explored. Finally, future outlook addressed.
Язык: Английский
Процитировано
7
Materials Today Chemistry, Год журнала: 2024, Номер 39, С. 102145 - 102145
Опубликована: Июнь 10, 2024
Язык: Английский
Процитировано
5