Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

MedComm, Год журнала: 2023, Номер 4(4)

Опубликована: Июль 14, 2023

Nanoparticles (NPs) have become one of the most popular objects scientific study during past decades. However, despite wealth reports, still there is a gap, particularly in health toxicology studies, underlying mechanisms, and related evaluation models to deeply understanding NPs risk effects. In this review, we first present comprehensive landscape applications on health, especially addressing role medical diagnosis, therapy. Then, toxicity systems introduced. We describe detail effects various systems, including respiratory, nervous, endocrine, immune, reproductive carcinogenicity NPs. Furthermore, unravels mechanisms ROS accumulation, mitochondrial damage, inflammatory reaction, apoptosis, DNA cell cycle, epigenetic regulation. addition, classical such as lines mice emerging 3D organoids used for evaluating or are both Overall, review presents critical summary state NPs, giving readers more better remedy key gaps knowledge techniques.

Язык: Английский

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Micro- and nanoplastics: A new cardiovascular risk factor?

Environment International, Год журнала: 2022, Номер 171, С. 107662 - 107662

Опубликована: Ноя. 26, 2022

Exposure to micro- and nanoplastics (MNPs) is inevitable due their omnipresence in the environment. A growing body of studies has advanced our understanding potential toxicity MNPs but knowledge gaps still exist regarding adverse effects on cardiovascular system underlying mechanisms, particularly humans. Here, we reviewed up-to-date data published past 10 years MNP-driven mechanisms. Forty-six articles concerning ADME (absorption, distribution, aggregation behaviors) circulatory animals human cells were analyzed summarized. The results showed that affected cardiac functions caused (micro)vascular sites. Direct included abnormal heart rate, function impairment, pericardial edema, myocardial fibrosis. On sites, induced hemolysis, thrombosis, blood coagulation, vascular endothelial damage. main mechanisms oxidative stress, inflammation, apoptosis, pyroptosis, interaction between multiple cellular components. Cardiovascular was determined by properties (type, size, surface, structure) MNPs, exposure dose duration, protein presence, life stage, sex, species tested organisms, as well with other environmental contamination. limited quantitative information MNPs' lack guidelines for MNP cardiotoxicity testing makes risk assessment health impossible. Furthermore, future directions research are recommended enable more realistic assessment.

Язык: Английский

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The potential toxicity of microplastics on human health

The Science of The Total Environment, Год журнала: 2023, Номер 912, С. 168946 - 168946

Опубликована: Дек. 2, 2023

Язык: Английский

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Polystyrene-microplastics and DEHP co-exposure induced DNA damage, cell cycle arrest and necroptosis of ovarian granulosa cells in mice by promoting ROS production

The Science of The Total Environment, Год журнала: 2023, Номер 871, С. 161962 - 161962

Опубликована: Фев. 10, 2023

Язык: Английский

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Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-κB/NLRP3 pathway

Chemosphere, Год журнала: 2022, Номер 307, С. 135662 - 135662

Опубликована: Июль 10, 2022

Язык: Английский

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Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Июнь 26, 2023

Microplastics and pesticides are emerging contaminants in the marine biota, which cause many harmful effects on aquatic organisms, especially fish. Fish is a staple affordable food source, rich animal protein, along with various vitamins, essential amino acids, minerals. Exposure of fish to microplastics, pesticides, nanoparticles generates ROS induces oxidative stress, inflammation, immunotoxicity, genotoxicity, DNA damage alters gut microbiota, thus reducing growth quality Changes behavioral patterns, swimming, feeding habits were also observed under exposures above contaminants. These affect Nrf-2, JNK, ERK, NF-κB, MAPK signaling pathways. And Nrf2-KEAP1 signalling modulates redox status marinating enzymes Effects found modulate antioxidant enzymes, including superoxide dismutase, catalase, glutathione system. So, protect health from contribution nano-technology or nano-formulations was researched. A decrease nutritional population significantly impacts human diet, influencing traditions economics worldwide. On other hand, traces microplastics habitat water can enter humans by consuming contaminated may result serious hazards. This review summarizes stress caused due nano-particle contamination exposure their impact health. As rescue mechanism, use management disease discussed.

Язык: Английский

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Atrazine exposure induces necroptosis through the P450/ROS pathway and causes inflammation in the gill of common carp (Cyprinus carpio L.)

Fish & Shellfish Immunology, Год журнала: 2022, Номер 131, С. 809 - 816

Опубликована: Окт. 17, 2022

Язык: Английский

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Microplastics induced inflammation and apoptosis via ferroptosis and the NF-κB pathway in carp

Aquatic Toxicology, Год журнала: 2023, Номер 262, С. 106659 - 106659

Опубликована: Авг. 14, 2023

Язык: Английский

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Evodiamine alleviates DEHP-induced hepatocyte pyroptosis, necroptosis and immunosuppression in grass carp through ROS-regulated TLR4 / MyD88 / NF-κB pathway

Fish & Shellfish Immunology, Год журнала: 2023, Номер 140, С. 108995 - 108995

Опубликована: Авг. 11, 2023

Язык: Английский

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Microplastic exposure induces muscle growth but reduces meat quality and muscle physiological function in chickens

The Science of The Total Environment, Год журнала: 2023, Номер 882, С. 163305 - 163305

Опубликована: Апрель 11, 2023

Язык: Английский

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