Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

MedComm, Journal Year: 2023, Volume and Issue: 4(4)

Published: July 14, 2023

Nanoparticles (NPs) have become one of the most popular objects scientific study during past decades. However, despite wealth reports, still there is a gap, particularly in health toxicology studies, underlying mechanisms, and related evaluation models to deeply understanding NPs risk effects. In this review, we first present comprehensive landscape applications on health, especially addressing role medical diagnosis, therapy. Then, toxicity systems introduced. We describe detail effects various systems, including respiratory, nervous, endocrine, immune, reproductive carcinogenicity NPs. Furthermore, unravels mechanisms ROS accumulation, mitochondrial damage, inflammatory reaction, apoptosis, DNA cell cycle, epigenetic regulation. addition, classical such as lines mice emerging 3D organoids used for evaluating or are both Overall, review presents critical summary state NPs, giving readers more better remedy key gaps knowledge techniques.

Language: Английский

---

Micro- and nanoplastics: A new cardiovascular risk factor?

Environment International, Journal Year: 2022, Volume and Issue: 171, P. 107662 - 107662

Published: Nov. 26, 2022

Exposure to micro- and nanoplastics (MNPs) is inevitable due their omnipresence in the environment. A growing body of studies has advanced our understanding potential toxicity MNPs but knowledge gaps still exist regarding adverse effects on cardiovascular system underlying mechanisms, particularly humans. Here, we reviewed up-to-date data published past 10 years MNP-driven mechanisms. Forty-six articles concerning ADME (absorption, distribution, aggregation behaviors) circulatory animals human cells were analyzed summarized. The results showed that affected cardiac functions caused (micro)vascular sites. Direct included abnormal heart rate, function impairment, pericardial edema, myocardial fibrosis. On sites, induced hemolysis, thrombosis, blood coagulation, vascular endothelial damage. main mechanisms oxidative stress, inflammation, apoptosis, pyroptosis, interaction between multiple cellular components. Cardiovascular was determined by properties (type, size, surface, structure) MNPs, exposure dose duration, protein presence, life stage, sex, species tested organisms, as well with other environmental contamination. limited quantitative information MNPs' lack guidelines for MNP cardiotoxicity testing makes risk assessment health impossible. Furthermore, future directions research are recommended enable more realistic assessment.

Language: Английский

---

Polystyrene-microplastics and DEHP co-exposure induced DNA damage, cell cycle arrest and necroptosis of ovarian granulosa cells in mice by promoting ROS production

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 871, P. 161962 - 161962

Published: Feb. 10, 2023

Language: Английский

---

The potential toxicity of microplastics on human health

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 168946 - 168946

Published: Dec. 2, 2023

Language: Английский

---

Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-κB/NLRP3 pathway

Chemosphere, Journal Year: 2022, Volume and Issue: 307, P. 135662 - 135662

Published: July 10, 2022

Language: Английский

---

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: June 26, 2023

Microplastics and pesticides are emerging contaminants in the marine biota, which cause many harmful effects on aquatic organisms, especially fish. Fish is a staple affordable food source, rich animal protein, along with various vitamins, essential amino acids, minerals. Exposure of fish to microplastics, pesticides, nanoparticles generates ROS induces oxidative stress, inflammation, immunotoxicity, genotoxicity, DNA damage alters gut microbiota, thus reducing growth quality Changes behavioral patterns, swimming, feeding habits were also observed under exposures above contaminants. These affect Nrf-2, JNK, ERK, NF-κB, MAPK signaling pathways. And Nrf2-KEAP1 signalling modulates redox status marinating enzymes Effects found modulate antioxidant enzymes, including superoxide dismutase, catalase, glutathione system. So, protect health from contribution nano-technology or nano-formulations was researched. A decrease nutritional population significantly impacts human diet, influencing traditions economics worldwide. On other hand, traces microplastics habitat water can enter humans by consuming contaminated may result serious hazards. This review summarizes stress caused due nano-particle contamination exposure their impact health. As rescue mechanism, use management disease discussed.

Language: Английский

---

Atrazine exposure induces necroptosis through the P450/ROS pathway and causes inflammation in the gill of common carp (Cyprinus carpio L.)

Fish & Shellfish Immunology, Journal Year: 2022, Volume and Issue: 131, P. 809 - 816

Published: Oct. 17, 2022

Language: Английский

---

Microplastics induced inflammation and apoptosis via ferroptosis and the NF-κB pathway in carp

Aquatic Toxicology, Journal Year: 2023, Volume and Issue: 262, P. 106659 - 106659

Published: Aug. 14, 2023

Language: Английский

---

Evodiamine alleviates DEHP-induced hepatocyte pyroptosis, necroptosis and immunosuppression in grass carp through ROS-regulated TLR4 / MyD88 / NF-κB pathway

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 140, P. 108995 - 108995

Published: Aug. 11, 2023

Language: Английский

---

Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens

Journal of Zhejiang University SCIENCE B, Journal Year: 2024, Volume and Issue: 25(3), P. 233 - 243

Published: March 1, 2024

Language: Английский

---