Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Июнь 26, 2023

Microplastics and pesticides are emerging contaminants in the marine biota, which cause many harmful effects on aquatic organisms, especially fish. Fish is a staple affordable food source, rich animal protein, along with various vitamins, essential amino acids, minerals. Exposure of fish to microplastics, pesticides, nanoparticles generates ROS induces oxidative stress, inflammation, immunotoxicity, genotoxicity, DNA damage alters gut microbiota, thus reducing growth quality Changes behavioral patterns, swimming, feeding habits were also observed under exposures above contaminants. These affect Nrf-2, JNK, ERK, NF-κB, MAPK signaling pathways. And Nrf2-KEAP1 signalling modulates redox status marinating enzymes Effects found modulate antioxidant enzymes, including superoxide dismutase, catalase, glutathione system. So, protect health from contribution nano-technology or nano-formulations was researched. A decrease nutritional population significantly impacts human diet, influencing traditions economics worldwide. On other hand, traces microplastics habitat water can enter humans by consuming contaminated may result serious hazards. This review summarizes stress caused due nano-particle contamination exposure their impact health. As rescue mechanism, use management disease discussed.

Язык: Английский

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Exposure to polystyrene microplastics triggers lung injury via targeting toll-like receptor 2 and activation of the NF-κB signal in mice

Environmental Pollution, Год журнала: 2023, Номер 320, С. 121068 - 121068

Опубликована: Янв. 11, 2023

Язык: Английский

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Polystyrene microplastics induce endoplasmic reticulum stress, apoptosis and inflammation by disrupting the gut microbiota in carp intestines

Environmental Pollution, Год журнала: 2023, Номер 323, С. 121233 - 121233

Опубликована: Фев. 14, 2023

Язык: Английский

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Polystyrene microplastics induced inflammation with activating the TLR2 signal by excessive accumulation of ROS in hepatopancreas of carp (Cyprinus carpio)

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 251, С. 114539 - 114539

Опубликована: Янв. 12, 2023

Polystyrene microplastics (PS-MPs) affect the immune defense function on carp (Cyprinus carpio). The PS-MPs model of was established by feeding with particle size 8 µm and concentration 1000 ng/L water. Hepatopancreas test revealed activities AKP, ALT, AST LDH abnormal increase. induced tissue damage lead to hepatopancreas function. also a oxidative stress antioxidant enzymes SOD, CAT, GSH-PX, T-AOC decreasing reactive oxygen species (ROS) excessive accumulation. activated Toll like receptor-2 (TLR2) signaling pathway. mRNA protein expressions TLR2, Myeloid differentiation primary response 88 (MyD88), tumor necrosis factor receptor-associated 6 (TRAF6), NF-κB p65, Tumor (TNF-α), Interleukin-1β (IL-1β), Inducible Nitric Oxide Synthase (iNOS), cycooxygenase 2(COX2) increased in both hepatocytes qPCR Western blotting analysis mode. ELISA showed TNF-α, IL-1β, iNOS, COX2 inflammatory molecule were hepatocytes. results that caused serious injure brought effects carp. present study displayed harm freshwater fish, provided some suggestions references for toxicological studies environment.

Язык: Английский

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Water physicochemical factors and oxidative stress physiology in fish, a review

Frontiers in Environmental Science, Год журнала: 2023, Номер 11

Опубликована: Сен. 15, 2023

Fish are among the best-studied aquatic animals due to their economic and ecological values. meat is most affordable protein source for economically weaker section of people. The environment almost all ecosystems has a specific influential role on or by fishes. Therefore, studying stress biology, especially oxidative stress, vital because it can influence growth, production, reproduction, etc. To review above topic, peer-reviewed electronic databases, including Web Science, science direct, PubMed, Google Scholar, Scopus, AGRICOLA, were searched with keywords associated fish, diseases, abiotic such as effects water dissolved oxygen, temperature, salinity, hardness, alkalinity, pH, pollutants, heavy metals, anthropogenic activities, was reviewed in current article draw conclusion updated relation that exists between fish physiology, disease, stressors. Oxidative redox regulatory levels under parameters anti-stress responses differ various models. Undoubtedly, factors modulate health status greater extent, therefore, these must be considered priority basis improve general immunity fish. statement remains valid both saline freshwater habitats.

Язык: Английский

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Baicalin suppressed necroptosis and inflammation against chlorpyrifos toxicity; involving in ER stress and oxidative stress in carp gills

Fish & Shellfish Immunology, Год журнала: 2023, Номер 139, С. 108883 - 108883

Опубликована: Июнь 5, 2023

Язык: Английский

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Microplastics induced inflammation and apoptosis via ferroptosis and the NF-κB pathway in carp

Aquatic Toxicology, Год журнала: 2023, Номер 262, С. 106659 - 106659

Опубликована: Авг. 14, 2023

Язык: Английский

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Micro/nano-plastics impacts in cardiovascular systems across species

The Science of The Total Environment, Год журнала: 2024, Номер 942, С. 173770 - 173770

Опубликована: Июнь 7, 2024

Язык: Английский

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A review of the neurobehavioural, physiological, and reproductive toxicity of microplastics in fishes

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 282, С. 116712 - 116712

Опубликована: Июль 15, 2024

Microplastics (MPs) have emerged as widespread environmental pollutants, causing significant threats to aquatic ecosystems and organisms.This review examines the toxic effects of MPs on fishes, with a focus neurobehavioural, physiological, reproductive impacts, well underlying mechanisms toxicity.Evidence indicates that induce range neurobehavioural abnormalities in affecting social interactions cognitive functions.Altered neurotransmitter levels are identified key mechanism driving behavioural alterations following MP exposure.Physiological fishes exposed also reported, including neurotoxicity, immunotoxicity, oxidative stress.These physiological disruptions can compromise individual health organisms.Furthermore, linked exposure discussed, particular emphasis endocrine signaling pathways.These impair success fish species, impacting population numbers.Here we explore critical role mediating after MPs, focusing primarily hypothalamic-pituitary-gonadal axis.Our highlights urgent need for interdisciplinary research efforts aimed at elucidating full extent toxicity its implications ecosystems.Lastly, identify knowledge gaps future research, investigations into transgenerational if any, quantifying synergetic/antagonistic other pollutants.This expanded regarding potential risks wildlife is expected aid policymakers developing mitigation strategies protect species.

Язык: Английский

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From plankton to fish: The multifaceted threat of microplastics in freshwater environments

Aquatic Toxicology, Год журнала: 2025, Номер 279, С. 107242 - 107242

Опубликована: Янв. 7, 2025

Язык: Английский

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