Redox Biology,
Год журнала:
2024,
Номер
70, С. 103063 - 103063
Опубликована: Фев. 2, 2024
Vascular
diseases,
a
leading
cause
of
death
in
human,
are
strongly
associated
with
pathological
damage
to
blood
vessels.
The
selenoprotein
(Sel)
have
been
reported
play
important
roles
vascular
disease.
However,
the
role
SelO
disease
has
not
conclusively
investigated.
present
experiment
was
investigate
regulatory
mechanism
effect
on
permeability
endothelial.
H.E
staining,
FITC-Dextran
Dil-AC-LDL
staining
and
FITC-WGA
showed
that
structure
damaged,
intercellular
junctions
were
disrupted
selenium
(Se)-deficient.
Immunohistochemistry,
qPCR
Western
blot
revealed
decreased
expression
adhesion
plaque
proteins
vinculin,
talin
paxillin,
connectivity
effector
molecules
connexin,
claudin-1
E-cadherin
increased
JAM-A
N-cadherin,
as
well
ZO-1
signaling
pathways
ZO-1,
Rock,
rhoGEF,
cingulin
MLC-2.
In
screening
24
Sel
mice,
most
pronounced
changes
tissues,
possible
association
between
junction
effectors
determined
using
IBM
SPSS
Statistics
25.
Silencing
SelO,
endothelial
adverse
effects
present.
relationship
determined.
results
Se
deficiency
lead
tissue
by
decreasing
expression,
suggesting
for
regulating
permeability.
Microbiology Spectrum,
Год журнала:
2024,
Номер
12(4)
Опубликована: Фев. 20, 2024
ABSTRACT
Given
the
burgeoning
Nyctereutes
procyonoides
breeding
industry
and
its
growing
scale,
it
is
imperative
to
investigate
impact
of
high-fat
diets
on
health
these
animals.
This
study
involved
30
male
comparable
weights
(3
kg
±0.5),
randomly
assigned
either
a
control
group
or
diet
(
n
=
15
each).
The
latter
was
fed
mixture
lard
basal
in
2:5
ratio,
establishing
model
procyonoides.
induced
diarrhea
histopathological
changes
Analysis
small
intestine
contents
using
16S
rRNA
sequencing
revealed
diet-induced
disruption
gut
microbiota.
Specifically,
Escherichia-Shigella
emerged
as
biomarker
P
0.049),
while
Vagococcus
prevalent
indicating
significant
increase
harmful
bacteria
group.
Furthermore,
this
disrupted
flora
correlated
with
inflammation
oxidative
stress,
evidenced
by
marked
increases
TNF-α
<
0.01),
IL-1β
0.05),
IL-6
0.05)
levels,
measured
via
q-PCR,
Western
blot,
stress
assays.
In
addition,
q-PCR
analysis
upregulation
apoptosis
necrosis
markers,
including
Bax,
Caspase3,
Caspase9,
Caspase12,
RIPK3,
RIPK1
0.01
0.001),
concurrent
downregulation
anti-apoptotic
gene
Bcl-2
0.01)
group,
consistent
protein
expression
trends.
These
findings
suggest
that
alters
microbiome
toward
more
bacterial
composition,
escalating
inflammatory
responses
intestinal
tissue
permeability,
culminating
cell
necrosis.
IMPORTANCE
examines
Our
research
established
diet,
revealing
impacts,
such
diarrhea,
histological
anomalies,
alterations
emphasize
importance
preventing
issues
promoting
sustainable
growth.
They
highlight
microbiota
overall
animal
health.
Food & Function,
Год журнала:
2024,
Номер
15(7), С. 3411 - 3419
Опубликована: Янв. 1, 2024
Tetrabromobisphenol
A
(TBBPA)
is
a
global
pollutant.
When
TBBPA
absorbed
by
the
body
through
various
routes,
it
can
have
wide
range
of
harmful
effects
on
body.
Green
tea
polyphenols
(GTPs)
act
as
antioxidants,
resisting
toxic
animals.
The
and
mechanisms
GTP
oxidative
stress,
inflammation
apoptosis
in
mouse
lung
are
unknown.
Therefore,
we
established
vivo
vitro
models
exposure
antagonism
using
C57
mice
A549
cells
examined
expression
factors
related
to
autophagy,
apoptosis.
results
study
showed
that
increase
reactive
oxygen
species
(ROS)
levels
after
decreased
autophagy-related
Beclin1,
LC3-II,
ATG3,
ATG5,
ATG7
ATG12
increased
p62;
stress
inhibits
autophagy
levels.
pro-inflammatory
IL-1β,
IL-6
TNF-α
anti-inflammatory
factor
IL-10
activation
NF-κB
p65/TNF-α
pathway.
Bax,
caspase-3,
caspase-7
caspase-9
Bcl-2
activate
apoptosis-related
pathways.
addition
attenuated
levels,
restored
inhibition
reduced
Our
suggest
attenuate
modulating
ROS,
reducing
increasing
attenuating
cells.
These
provide
fundamental
information
for
exploring
antioxidant
mechanism
further
studying
TBBPA.
Food & Function,
Год журнала:
2024,
Номер
15(13), С. 7136 - 7147
Опубликована: Янв. 1, 2024
Zinc
(Zn)
is
an
important
trace
element;
it
involved
in
the
regulation
and
maintenance
of
many
physiological
functions
organisms
has
anti-inflammatory
antioxidant
properties.
Biomolecules,
Год журнала:
2025,
Номер
15(4), С. 462 - 462
Опубликована: Март 21, 2025
Plastic
pollution
has
become
one
of
the
major
environmental
problems
facing
human
beings
in
world
today.
waste
accumulated
environment
forms
plastic
particles
different
sizes
due
to
farming
activities,
climate
change,
ultraviolet
light,
microbial
degradation,
and
animal
chewing.
The
caused
by
microplastics
a
problem
recent
years,
it
is
also
research
hotspot
field
ecological
environment.
More
more
studies
have
found
that
ruminants
are
exposed
for
long
time,
which
seriously
threaten
their
healthy
growth.
This
paper
introduces
current
situation
pollution;
properties
effects
on
environment,
beings,
animals;
summarizes
types
toxicity
mechanisms
microplastics;
concludes
main
ways
enter
harm
them.
In
addition,
shortcomings
future
development
summarized
prospected
provide
theoretical
reference
related
alleviating
influence
ruminant
production.
Toxics,
Год журнала:
2024,
Номер
12(7), С. 475 - 475
Опубликована: Июнь 29, 2024
Micro-
and
nano-plastics
(MNPs)
are
ubiquitously
distributed
in
the
environment,
infiltrate
organisms
through
multiple
pathways,
accumulate,
thus
posing
potential
threats
to
human
health.
MNP
exposure
elicits
changes
microRNAs
(miRNAs),
long
noncoding
RNAs
(lncRNAs),
circular
(circRNAs),
thereby
precipitating
immune,
neurological,
other
toxic
effects.
The
investigation
of
its
effect
on
miRNA
expression
has
garnered
increasing
attention.
Following
exposure,
circRNAs
serve
as
sponges
by
modulating
gene
expression,
while
lncRNAs
function
competing
endogenous
(ceRNAs)
fine-tuning
target
consequently
impacting
protein
translation
physiological
processes
cells.
Dysregulated
mediates
mitochondrial
dysfunction,
inflammation,
oxidative
stress,
risk
neurodegenerative
diseases,
cardiovascular
cancer.
This
tract,
blood,
urine,
feces,
placenta,
review
delves
into
biotoxicity
arising
from
dysregulated
due
addresses
challenges
encountered
this
field.
study
provides
novel
insights
connections
between
MNPs
disease
risk.
