Non-Coding RNA,
Год журнала:
2023,
Номер
9(6), С. 75 - 75
Опубликована: Дек. 11, 2023
Allergy
is
a
type
2
immune
reaction
triggered
by
antigens
known
as
allergens,
including
food
and
environmental
substances
such
peanuts,
plant
pollen,
fungal
spores,
the
feces
debris
of
mites
insects.
Macrophages
are
myeloid
cells
with
phagocytic
abilities
that
process
exogenous
endogenous
antigens.
Upon
activation,
they
can
produce
effector
molecules
cytokines
well
anti-inflammatory
molecules.
The
dysregulation
macrophage
function
lead
to
excessive
1
inflammation
inflammation,
which
includes
allergic
reactions.
Thus,
it
important
better
understand
how
macrophages
regulated
in
pathogenesis
allergies.
Emerging
evidence
highlights
role
noncoding
RNAs
(ncRNAs)
polarization,
turn
modify
various
immune-mediated
diseases,
This
review
summarizes
current
knowledge
regarding
this
topic
considers
three
classes
ncRNAs:
microRNAs,
long
ncRNAs,
circular
ncRNAs.
Understanding
roles
these
ncRNAs
polarization
will
provide
new
insights
into
allergies
identify
potential
novel
therapeutic
targets.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 10, 2024
Macrophages
are
crucial
cells
in
the
human
body's
innate
immunity
and
engaged
a
variety
of
non-inflammatory
reactions.
can
develop
into
two
kinds
when
stimulated
by
distinct
internal
environments:
pro-inflammatory
M1-like
macrophages
anti-inflammatory
M2-type
macrophages.
During
inflammation,
activated
alternatively,
maintaining
reasonably
steady
ratio
is
critical
for
homeostasis
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 2670 - 2670
Опубликована: Фев. 25, 2024
Over
the
past
century,
molecular
biology’s
focus
has
transitioned
from
proteins
to
DNA,
and
now
RNA.
Once
considered
merely
a
genetic
information
carrier,
RNA
is
recognized
as
both
vital
element
in
early
cellular
life
regulator
complex
organisms.
Long
noncoding
RNAs
(lncRNAs),
which
are
over
200
bases
long
but
do
not
code
for
proteins,
play
roles
gene
expression
regulation
signal
transduction
by
inducing
epigenetic
changes
or
interacting
with
various
RNAs.
These
interactions
exhibit
range
of
functions
cell
types,
including
macrophages.
Notably,
some
macrophage
lncRNAs
influence
activation
NF-κB,
crucial
transcription
factor
governing
immune
inflammatory
responses.
Macrophage
NF-κB
instrumental
progression
pathological
conditions
sepsis,
atherosclerosis,
cancer,
autoimmune
disorders,
hypersensitivity.
It
orchestrates
related
responses,
inflammation,
survival,
proliferation.
Consequently,
its
malfunction
key
contributor
onset
development
these
diseases.
This
review
aims
summarize
function
regulating
activity
particular
emphasis
on
their
relevance
human
diseases
potential
therapeutic
targets.
The
insights
gained
studies
lncRNAs,
discussed
this
review,
could
provide
valuable
knowledge
treatments
involving
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Май 18, 2024
Abstract
Interactions
of
tumor
cells
with
immune
in
the
microenvironment
play
an
important
role
during
malignancy
progression.
We
previously
identified
that
GAS5
inhibited
development
by
suppressing
proliferation
non-small
cell
lung
cancer
(NSCLC).
Herein,
we
discovered
a
tumor-suppressing
for
cell-derived
regulating
microenvironment.
positively
coordinated
infiltration
macrophages
and
T
NSCLC
clinically,
overexpression
promoted
recruitment
both
vitro
vivo.
Mechanistically,
stabilized
p53
directly
binding
to
MYBBP1A
facilitating
MYBBP1A-p53
interaction,
enhanced
p53-mediated
transcription
IRF1,
which
activated
type
I
interferon
signaling
increased
production
downstream
CXCL10
CCL5.
also
found
activation
was
associated
better
immunotherapy
efficacy
NSCLC.
Furthermore,
stability
regulated
NAT10,
key
enzyme
responsible
N4-acetylcytidine
(ac4C)
modification,
bound
mediated
its
ac4C
modification.
Collectively,
could
activate
via
MYBBP1A-p53/IRF1
axis,
promoting
potentially
correlating
efficacy,
suppressed
Our
results
suggested
as
promising
predictive
marker
potential
therapeutic
target
combination
therapy
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июль 4, 2024
In
recent
years,
the
relationship
between
vitamin
D
and
allergic
diseases
has
received
widespread
attention.
As
a
fat-soluble
vitamin,
plays
crucial
role
in
regulating
immune
system
may
influence
onset
progression
of
such
as
atopic
dermatitis,
rhinitis,
asthma.
To
understand
underlying
mechanisms,
we
have
summarized
current
research
on
association
diseases.
We
also
discuss
impact
its
course
diseases,
particularly
focusing
how
supplementation
affects
treatment
outcomes
these
conditions.
aim
to
provide
theoretical
basis
practical
guidance
for
optimizing
management
by
modulating
levels.
International Journal of General Medicine,
Год журнала:
2025,
Номер
Volume 18, С. 529 - 565
Опубликована: Фев. 1, 2025
Abstract:
Allergic
rhinitis
(AR)
is
a
prevalent
allergic
disease
that
imposes
significant
economic
burdens
and
life
pressures
on
individuals,
families,
society,
particularly
in
the
context
of
accelerating
globalization
increasing
pathogenic
factors.
Current
clinical
therapies
for
AR
include
antihistamines,
glucocorticoids
administered
via
various
routes,
leukotriene
receptor
antagonists,
immunotherapy,
several
decongestants.
These
treatments
have
demonstrated
efficacy
alleviating
symptoms
pathological
states.
However,
with
growing
awareness
rising
expectations
improvements
quality
life,
these
become
associated
higher
incidence
side
effects
an
elevated
risk
drug
resistance.
Furthermore,
development
intricately
dysregulation
immune
system,
yet
underlying
pathogenetic
mechanisms
remain
incompletely
understood.
In
contrast,
widely
available
natural
plant
molecules
offer
multiple
targeting
pathways
uniquely
modify
typical
pathophysiology
through
immunomodulatory
processes.
This
review
presents
comprehensive
analysis
both
vivo
vitro
studies
modulate
immunity
treating
AR.
Additionally,
we
examine
their
specific
action
animal
models
to
provide
new
insights
developing
safe
effective
targeted
while
guiding
experimental
applications
against
Keywords:
molecules,
rhinitis,
immunomodulation,
therapeutic
mechanism,
research
progress
