Regulation of Macrophage Polarization in Allergy by Noncoding RNAs DOI Creative Commons
Osamu Ishibashi, Stefan A. Muljo, Zohirul Islam

et al.

Non-Coding RNA, Journal Year: 2023, Volume and Issue: 9(6), P. 75 - 75

Published: Dec. 11, 2023

Allergy is a type 2 immune reaction triggered by antigens known as allergens, including food and environmental substances such peanuts, plant pollen, fungal spores, the feces debris of mites insects. Macrophages are myeloid cells with phagocytic abilities that process exogenous endogenous antigens. Upon activation, they can produce effector molecules cytokines well anti-inflammatory molecules. The dysregulation macrophage function lead to excessive 1 inflammation inflammation, which includes allergic reactions. Thus, it important better understand how macrophages regulated in pathogenesis allergies. Emerging evidence highlights role noncoding RNAs (ncRNAs) polarization, turn modify various immune-mediated diseases, This review summarizes current knowledge regarding this topic considers three classes ncRNAs: microRNAs, long ncRNAs, circular ncRNAs. Understanding roles these ncRNAs polarization will provide new insights into allergies identify potential novel therapeutic targets.

Language: Английский

Macrophage polarization: an important role in inflammatory diseases DOI Creative Commons
Min Luo,

Fukun Zhao,

Huan Cheng

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 10, 2024

Macrophages are crucial cells in the human body's innate immunity and engaged a variety of non-inflammatory reactions. can develop into two kinds when stimulated by distinct internal environments: pro-inflammatory M1-like macrophages anti-inflammatory M2-type macrophages. During inflammation, activated alternatively, maintaining reasonably steady ratio is critical for homeostasis

Language: Английский

Citations

77
Roles of lncRNAs in NF-κB-Mediated Macrophage Inflammation and Their Implications in the Pathogenesis of Human Diseases DOI Open Access

Jae-Joon Shin,

Jeongkwang Park,

Hyeung‐Seob Shin

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2670 - 2670

Published: Feb. 25, 2024

Over the past century, molecular biology’s focus has transitioned from proteins to DNA, and now RNA. Once considered merely a genetic information carrier, RNA is recognized as both vital element in early cellular life regulator complex organisms. Long noncoding RNAs (lncRNAs), which are over 200 bases long but do not code for proteins, play roles gene expression regulation signal transduction by inducing epigenetic changes or interacting with various RNAs. These interactions exhibit range of functions cell types, including macrophages. Notably, some macrophage lncRNAs influence activation NF-κB, crucial transcription factor governing immune inflammatory responses. Macrophage NF-κB instrumental progression pathological conditions sepsis, atherosclerosis, cancer, autoimmune disorders, hypersensitivity. It orchestrates related responses, inflammation, survival, proliferation. Consequently, its malfunction key contributor onset development these diseases. This review aims summarize function regulating activity particular emphasis on their relevance human diseases potential therapeutic targets. The insights gained studies lncRNAs, discussed this review, could provide valuable knowledge treatments involving

Language: Английский

Citations

10
NAT10-mediated upregulation of GAS5 facilitates immune cell infiltration in non-small cell lung cancer via the MYBBP1A-p53/IRF1/type I interferon signaling axis DOI Creative Commons
Zimu Wang, Jing Luo, Hairong Huang

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: May 18, 2024

Abstract Interactions of tumor cells with immune in the microenvironment play an important role during malignancy progression. We previously identified that GAS5 inhibited development by suppressing proliferation non-small cell lung cancer (NSCLC). Herein, we discovered a tumor-suppressing for cell-derived regulating microenvironment. positively coordinated infiltration macrophages and T NSCLC clinically, overexpression promoted recruitment both vitro vivo. Mechanistically, stabilized p53 directly binding to MYBBP1A facilitating MYBBP1A-p53 interaction, enhanced p53-mediated transcription IRF1, which activated type I interferon signaling increased production downstream CXCL10 CCL5. also found activation was associated better immunotherapy efficacy NSCLC. Furthermore, stability regulated NAT10, key enzyme responsible N4-acetylcytidine (ac4C) modification, bound mediated its ac4C modification. Collectively, could activate via MYBBP1A-p53/IRF1 axis, promoting potentially correlating efficacy, suppressed Our results suggested as promising predictive marker potential therapeutic target combination therapy

Language: Английский

Citations

9
Vitamin D and allergic diseases DOI Creative Commons

Panyu Zhang,

Qingxiu Xu, Rongfei Zhu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 4, 2024

In recent years, the relationship between vitamin D and allergic diseases has received widespread attention. As a fat-soluble vitamin, plays crucial role in regulating immune system may influence onset progression of such as atopic dermatitis, rhinitis, asthma. To understand underlying mechanisms, we have summarized current research on association diseases. We also discuss impact its course diseases, particularly focusing how supplementation affects treatment outcomes these conditions. aim to provide theoretical basis practical guidance for optimizing management by modulating levels.

Language: Английский

Citations

8
Neuron-derived exosomes mediate sevoflurane-induced neurotoxicity in neonatal mice via transferring lncRNA Gas5 and promoting M1 polarization of microglia DOI
Lili Xu,

Jiaqian Xie,

Jianjun Shen

et al.

Acta Pharmacologica Sinica, Journal Year: 2023, Volume and Issue: 45(2), P. 298 - 311

Published: Oct. 6, 2023

Language: Английский

Citations

13
Potential mechanisms of rheumatoid arthritis therapy: Focus on macrophage polarization DOI

Xinyu Yang,

Jinling Li, Chengchao Xu

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113058 - 113058

Published: Sept. 4, 2024

Language: Английский

Citations

4
Exploring Advances in Natural Plant Molecules for Allergic Rhinitis Immunomodulation in Vivo and in Vitro DOI Creative Commons

Bingquan Li,

Boyang Dong,

Liangzhen Xie

et al.

International Journal of General Medicine, Journal Year: 2025, Volume and Issue: Volume 18, P. 529 - 565

Published: Feb. 1, 2025

Abstract: Allergic rhinitis (AR) is a prevalent allergic disease that imposes significant economic burdens and life pressures on individuals, families, society, particularly in the context of accelerating globalization increasing pathogenic factors. Current clinical therapies for AR include antihistamines, glucocorticoids administered via various routes, leukotriene receptor antagonists, immunotherapy, several decongestants. These treatments have demonstrated efficacy alleviating symptoms pathological states. However, with growing awareness rising expectations improvements quality life, these become associated higher incidence side effects an elevated risk drug resistance. Furthermore, development intricately dysregulation immune system, yet underlying pathogenetic mechanisms remain incompletely understood. In contrast, widely available natural plant molecules offer multiple targeting pathways uniquely modify typical pathophysiology through immunomodulatory processes. This review presents comprehensive analysis both vivo vitro studies modulate immunity treating AR. Additionally, we examine their specific action animal models to provide new insights developing safe effective targeted while guiding experimental applications against Keywords: molecules, rhinitis, immunomodulation, therapeutic mechanism, research progress

Language: Английский

Citations

0
Targeting the lncRNA GAS5/TLR4/NLRP3 signaling cascade inhibits endometrial stromal cell pyroptosis and prevents the progression of intrauterine adhesions DOI

Yifeng Zhang,

Dongjie Wang, Xiaomei Wu

et al.

Journal of Reproductive Immunology, Journal Year: 2025, Volume and Issue: 168, P. 104450 - 104450

Published: Feb. 7, 2025

Language: Английский

Citations

0
LncRNA FOXD3-AS1 modulates ER stress and epithelial barrier dysfunction in allergic rhinitis by destabilizing CHOP mRNA DOI
Hao Zhang, Yaqiong Zhu, Chunping Yang

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111737 - 111737

Published: March 1, 2025

Language: Английский

Citations

0
Advances in co-pathogenesis of the united airway diseases DOI

Xinjun Xu,

Jiali Yin, Yujuan Yang

et al.

Respiratory Medicine, Journal Year: 2024, Volume and Issue: 225, P. 107580 - 107580

Published: March 12, 2024

Language: Английский

Citations

2