The Role of Diet and Nutritional Interventions for the Infant Gut Microbiome

Nutrients, Год журнала: 2024, Номер 16(3), С. 400 - 400

Опубликована: Янв. 30, 2024

The infant gut microbiome plays a key role in the healthy development of human organism and appears to be influenced by dietary practices through multiple pathways. First, maternal diet during pregnancy nutrition significantly influence microbiota. Moreover, breastfeeding fosters proliferation beneficial bacteria, while formula feeding increases microbial diversity. timing introducing solid foods also influences microbiota composition. In preterm infants is factors, including time since birth intake breast milk, interventions such as probiotics prebiotics supplementation show promising results reducing morbidity mortality this population. These findings underscore need for future research understand long-term health impacts these further strategies enrich formula-fed infants.

Язык: Английский

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Birthmode and environment-dependent microbiota transmission dynamics are complemented by breastfeeding during the first year

Cell Host & Microbe, Год журнала: 2024, Номер 32(6), С. 996 - 1010.e4

Опубликована: Июнь 1, 2024

The composition and maturation of the early-life microbiota are modulated by a number perinatal factors, whose interplay in relation to microbial vertical transmission remains inadequately elucidated. Using recent strain-tracking methodologies, we analyzed mother-to-infant two different birth environments: hospital-born (vaginal/cesarean) home-born (vaginal) infants their mothers. While delivery mode primarily explains initial compositional differences, place impacts timing-being early homebirths delayed cesarean deliveries. Transmission patterns vary greatly across species groups, yet certain species, like Bifidobacterium longum, consistently vertically transmitted regardless setting. Strain-level analysis B. longum highlights relevant consistent subspecies replacement mainly explained breastfeeding practices, which drive changes human milk oligosaccharide (HMO) degrading capabilities. Our findings highlight how setting, duration, other lifestyle preferences collectively shape transmission, impacting infant gut colonization during life.

Язык: Английский

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Maternal diet and gut microbiome composition modulate early‐life immune development

EMBO Molecular Medicine, Год журнала: 2023, Номер 15(8)

Опубликована: Июнь 6, 2023

Abstract In early life, the intestinal mucosa and immune system undergo a critical developmental process to contain expanding gut microbiome while promoting tolerance toward commensals, yet influence of maternal diet microbial composition on offspring maturation remains poorly understood. We colonized germ‐free mice with consortium 14 strains, fed them standard fiber‐rich chow or fiber‐free diet, then longitudinally assessed development during weaning period. Unlike pups born dams fiber‐deprived demonstrated delayed colonization Akkermansia muciniphila , mucin‐foraging bacterium that can also use milk oligosaccharides. The exhibited an enrichment colonic transcripts corresponding defense response pathways peak in Il22 expression at weaning. Removal A . from community, but maintenance was associated reduced proportions RORγt‐positive innate adaptive cell subsets. Our results highlight potent dietary fiber intake discrete changes postnatal assemblage development.

Язык: Английский

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Identifying Children at Risk of Growth and Nutrient Deficiencies in the Food Allergy Clinic

The Journal of Allergy and Clinical Immunology In Practice, Год журнала: 2024, Номер 12(3), С. 579 - 589

Опубликована: Янв. 25, 2024

Язык: Английский

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From Birth to Weaning: A Window of Opportunity for Microbiota

Nutrients, Год журнала: 2024, Номер 16(2), С. 272 - 272

Опубликована: Янв. 17, 2024

(1) Background: The first 1000 days of life constitute a critical window opportunity for microbiota development. Nutrients play crucial role in enriching and diversifying the microbiota, derived not only from solid food but also maternal dietary patterns during gestation. (2) Methods: We conducted comprehensive literature review using PubMed database, covering eleven years (2013–2023). included English-language reviews, original research papers, meta-analyses, while excluding case reports letters. (3) Results: Consensus emphasizes that our interaction with multitude microorganisms begins intrauterine environment continues throughout lives. existing data suggest early nutritional education programs, initiated pregnancy guiding infant diets development, may influence shaping gut promoting long-term health. (4) Conclusions: Further is necessary coming to assess potential interventions models aimed at modulating pediatric especially vulnerable populations such as premature newborns.

Язык: Английский

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Copper exposure causes alteration in the intestinal microbiota and metabolites in Takifugu rubripes

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 272, С. 116064 - 116064

Опубликована: Фев. 10, 2024

Copper is an environmental pollutant, and copper in aquatic environments mainly comes from soil water. It enters the environment through atmospheric deposition, sewage discharge, industrial production, organisms, causing toxicity. Takifugu rubripes (T. rubripes) a marine fish with high economic value. Due to toxic effects of heavy metals on organisms such as fish, it can affect gut community metabolites fish. The important channel for communicate outside world necessary pathway metabolism nutrients substances body. Studies have shown that due changes global water emissions sensitivity environment, may pose greater potential hazards organisms. poses risk species than other metal/metal like pollutants (such cadmium, lead, mercury, arsenic, etc.) . In order elucidate exposure T. rubripes. this study, we exposed 0, 50, 100, or 500 μg/L three days, microbiota structure were investigated using 16 S rRNA gene metabolomics techniques. research results indicate increase concentration, intestinal tissue undergoes significant damage. sequencing show alters microbiota. 100 inhibited colonization bacterial gut, disrupted barrier, made susceptible pathogens. Liquid chromatography–mass spectrometry analysis showed regulated production L-histidine, arachidonic acid, L-glutamic which are related energy immunity. Microbiome–metabolome correlation Subdoligranulum, Family_XIII_AD3011_group, Clostridium_sensu_stricto_1 key bacteria ion intervention, they might up-regulate levels indole-3-acetic 3-indoleacrylic 5-hydroxyindole tryptophan pathway. summary, our has demonstrated cause pathological High concentrations ions intestine, damage fish's immune system, alter microbiota, lead metabolic dysfunction. providing reference evaluation biological toxicity metal elements environment. This study provides evaluating environments.

Язык: Английский

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Probiotics in the New Era of Human Milk Oligosaccharides (HMOs): HMO Utilization and Beneficial Effects of Bifidobacterium longum subsp. infantis M-63 on Infant Health

Microorganisms, Год журнала: 2024, Номер 12(5), С. 1014 - 1014

Опубликована: Май 17, 2024

A healthy gut microbiome is crucial for the immune system and overall development of infants. Bifidobacterium has been known to be a predominant species in infant gut; however, an emerging concern apparent loss this genus, particular, longum subsp. infantis (B. infantis) infants industrialized nations, underscoring importance restoring beneficial bacterium. With growing understanding microbiome, probiotics, especially infant-type human-residential bifidobacteria (HRB) strains like B. infantis, are gaining prominence their unique ability utilize HMOs positively influence health. This article delves into physiology probiotic strain, M-63, its symbiotic relationship with HMOs, potential improving gastrointestinal allergic conditions children. Moreover, critically assesses role trend supplementing formulas prebiotic which serve as fuel bacteria, thereby emulating protective effects breastfeeding. The review highlights combining M-63 feasible strategy improve health outcomes children, acknowledging complexities requirements further research area.

Язык: Английский

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Translating neonatal microbiome science into commercial innovation: metabolism of human milk oligosaccharides as a basis for probiotic efficacy in breast-fed infants

Gut Microbes, Год журнала: 2023, Номер 15(1)

Опубликована: Апрель 3, 2023

For over a century, physicians have witnessed common enrichment of bifidobacteria in the feces breast-fed infants that was readily associated with infant health status. Recent advances bacterial genomics, metagenomics, and glycomics helped explain nature this unique enabled tailored use probiotic supplementation to restore missing bifidobacterial functions at-risk infants. This review documents 20-year span discoveries set stage for current human milk oligosaccharide-consuming beneficially colonize, modulate, protect intestines at-risk, milk-fed, neonates. also presents model applications wherein functions, form colonization HMO-related catabolic activity situ, represent measurable metabolic outcomes by which efficacy can be scored toward improving health.

Язык: Английский

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Gut microbiome in the first 1000 days and risk for childhood food allergy

Annals of Allergy Asthma & Immunology, Год журнала: 2024, Номер 133(3), С. 252 - 261

Опубликована: Март 16, 2024

Язык: Английский

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Breastfeeding Beyond Six Months: Evidence of Child Health Benefits

Nutrients, Год журнала: 2024, Номер 16(22), С. 3891 - 3891

Опубликована: Ноя. 14, 2024

Breastfeeding is globally recognized as the optimal method of infant nutrition, offering health benefits for both child and mother, making it a public priority. However, potential advantages breastfeeding extend well beyond initial months. Breast milk adapts to evolving needs growing infant, its immunological, microbiological, biochemical properties have been associated with enhanced protection against infections chronic diseases, improved growth development, lower rates hospitalization mortality. This review explores evidence supporting continuation six More meticulous studies employing consistent methodologies addressing confounders are essential. will enable more accurate determination extent mechanisms positive impact prolonged allow implementation effective strategies.

Язык: Английский

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