Sensors,
Год журнала:
2024,
Номер
25(1), С. 186 - 186
Опубликована: Дек. 31, 2024
In
this
study,
an
approach
has
been
proposed
in
response
to
the
urgent
need
for
a
sensitive
and
stable
method
glucose
detection
at
low
concentrations.
Platinum
octaethylporphyrin
(PtOEP)
was
chosen
as
probe
embedded
into
matrix
material
yield
glucose-sensing
film,
i.e.,
Pt/TE-MTS,
through
sol–gel
process.
The
optical
parameter
(OP)
defined
ratio
of
phosphorescence
absence
presence
glucose,
relationship
between
OP
concentration
(GC)
established
theoretical
way
based
on
Stern–Volmer
equation
further
obtained
by
photoluminescence
measurement.
exhibited
linear
with
GC
range
0–720
μM.
time
required
film
reach
equilibrium
measured
ensure
completion
reaction,
it
found
that
decreased
increased.
photobleaching
behavior
stabilization
were
monitored,
result
showed
excellent
resistance
quite
aqueous
solution.
Additionally,
LabVIEW-based
GC-detection
system
developed
achieve
practical
application
sensing
film.
summary,
Pt/TE-MTS
high
sensitivity
detecting
reproducibility,
which
is
value
applications.
ACS Materials Letters,
Год журнала:
2024,
Номер
6(4), С. 1160 - 1177
Опубликована: Фев. 26, 2024
The
complexity
of
the
cancer
microenvironment
makes
it
highly
challenging
for
drugs
to
meet
therapeutic
requirements,
significantly
hampering
their
clinical
translation.
enormous
potential
intelligent
materials
that
can
act
as
themselves
results
in
development
smart
drugless
or
drug-like
architectures,
offering
synergistic
effects.
In
this
study,
we
demonstrate
generation
transition
metal-based
dichalcogenides
(TMDCs)-based
conformational
(flower-like)
nanoarchitectonics
trimodal
therapies
against
breast
carcinoma.
Initially,
progressive
transformation
two-dimensional
(2D)
molybdenum
selenide
(MoSe2)-based
nanosheets
into
nanoflower-like
architectures
by
thermal
injection
method
is
observed
with
time.
Further,
these
flowers
are
subsequently
decorated
an
optimal
amount
platinum
(Pt)
nanoparticles
nanocatalytic
efficacy
and
surface-modified
polyethylene
glycol
(PEG)
improved
biocompatibility,
shortly
denoted
Pt-MoSe2-PEG
light-assisted
photothermal
(PTT)
photodynamic
(PDT),
well
light-augmented
chemodynamic
(CDT)
modalities.
A
series
physicochemical
characterizations
performance
validations
successfully
demonstrated
tumor
(pH/GSH)-responsive
degradable
structures,
substantially
improving
ability
reactive
oxygen
species
generation,
MoSe2-based
PTT/PDT
capability,
CDT
Pt
nanoenzymes.
Finally,
vitro
vivo
investigations
4T1
cell
line
its
xenograft
model
BALB/C
mice,
respectively,
validated
toward
ablating
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Nanozymes
have
shown
significant
potential
in
cancer
catalytic
therapy
by
strategically
catalyzing
tumor-associated
substances
and
metabolites
into
toxic
reactive
oxygen
species
(ROS)
situ,
thereby
inducing
oxidative
stress
promoting
cell
death.
However,
within
the
complex
tumor
microenvironment
(TME),
rational
design
of
nanozymes
factors
like
activity,
reaction
substrates,
TME
itself
significantly
influence
efficiency
ROS
generation.
To
address
these
limitations,
recent
research
has
focused
on
exploring
that
affect
activity
developing
nanozyme-based
cascade
systems,
which
can
trigger
two
or
more
processes
tumors,
producing
therapeutic
achieving
efficient
stable
with
minimal
side
effects.
This
area
remarkable
progress.
Perspective
provides
a
comprehensive
overview
nanozymes,
covering
their
classification
fundamentals.
The
regulation
nanozyme
strategies
are
discussed
detail.
Furthermore,
representative
paradigms
for
successful
construction
systems
treatment
summarized
focus
revealing
underlying
mechanisms.
Finally,
we
current
challenges
future
prospects
development
biomedical
applications.
