Abstract
The
strong
anti‐inflammatory
effect
of
methylprednisolone
(MP)
is
a
necessary
treatment
for
various
severe
cases
including
acute
spinal
cord
injury
(SCI).
However,
concerns
have
been
raised
regarding
adverse
effects
from
MP,
which
also
severely
limits
its
clinical
application.
Natural
polyphenols,
due
to
their
rich
phenolic
hydroxyl
chemical
properties,
can
form
dynamic
structures
without
additional
modification,
achieving
targeted
enrichment
and
drug
release
at
the
disease
lesion,
making
them
highly
promising
carrier.
Considering
application
challenges
natural
polyphenolic
platform
employed
efficient
delivery
reducing
systemic
side
effects.
Both
in
vitro
SCI
models
demonstrated
polyphenols
multiple
advantages
as
carriers
delivering
MP:
(1)
Achieved
maximum
injured
site
2
h
post‐administration,
met
desires
early
diseases;
(2)
Traceless
MP;
(3)
Reducing
effects;
(4)
Endowed
system
with
new
antioxidative
an
aspect
that
needs
be
addressed
diseases
treatment.
This
study
highlighted
prospect
robust
based
on
successfully
overcome
barrier
MP
treatment,
providing
possibility
widespread
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Ноя. 5, 2023
Abstract
Marine
resources
in
unique
marine
environments
provide
abundant,
cost-effective
natural
biomaterials
with
distinct
structures,
compositions,
and
biological
activities
compared
to
terrestrial
species.
These
marine-derived
raw
materials,
including
polysaccharides,
protein
components,
fatty
acids,
minerals,
etc.,
have
shown
great
potential
preparing,
stabilizing,
or
modifying
multifunctional
nano-/micro-systems
are
widely
applied
drug
delivery,
theragnostic,
tissue
engineering,
etc.
This
review
provides
a
comprehensive
summary
of
the
most
current
biomaterial-based
developed
over
past
three
years,
primarily
focusing
on
therapeutic
delivery
studies
highlighting
their
cure
variety
diseases.
Specifically,
we
first
provided
detailed
introduction
physicochemical
characteristics
biocomponents
state.
Furthermore,
assembly
processes,
functionalities
each
building
block,
thorough
evaluation
pharmacokinetics
pharmacodynamics
advanced
systems
effects
molecular
pathophysiological
processes
were
fully
elucidated.
Finally,
list
unresolved
issues
pivotal
challenges
applications,
such
as
standardized
distinction
long-term
biosafety
vivo,
feasibility
scale-up,
was
presented.
is
expected
serve
roadmap
for
fundamental
research
facilitate
rational
design
diverse
emerging
applications.
Graphical
Natural
polymers
have
been
widely
studied
as
the
carriers
for
transfer
of
medications
and
different
therapeutic
molecules,
which
attracted
significant
attention.
polymers'
inherent
benefits
in
extraordinary
biocompatibility,
controlled
enzyme
degradation,
particular
interactions
with
several
biomolecules,
simple
modification
endow
them
versatility
drug
delivery.
In
lung
diseases,
using
natural
delivery
methods
can
enhance
effectiveness
drugs
because
their
associated
sustained
discharge,
targeting
efficacy,
patient
compliance.
this
context,
explored
to
match
demand,
including
chitosan,
polysaccharides,
alginate,
gelatin.
Moreover,
system
produced
by
polymer
derivatives
has
offered
focus
on
chemical
morphological
alterations,
decorations
smart
stimuli-responsive
or
targeted
motifs,
so
on,
improved
treatment
effectiveness.
More
intelligent
approaches
developed,
more
multifunctional
polymer-based
are
used
future.
This
chapter
contains
progressions
that
cancer
respiratory
diseases.
The
section
at
end
also
shows
future
systems
combating
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(23)
Опубликована: Май 11, 2023
Abstract
Pulmonary
inflammation
is
one
of
the
most
reported
tissue
inflammations
in
clinic.
Successful
suppression
vital
to
prevent
further
inevitably
fatal
lung
degeneration.
Glucocorticoid
hormone,
such
as
methylprednisolone
(MP),
applied
strategy
control
inflammatory
progression
yet
faces
challenge
systemic
side
effects
caused
by
requirement
large‐dosage
and
frequent
administration.
Highly
efficient
delivery
MP
specifically
targeted
sites
may
overcome
this
challenge.
Therefore,
present
study
develops
an
inflammation‐targeted
biomimetic
nanovehicle,
which
hybridizes
cell
membrane
mesenchymal
stem
with
liposome,
named
MSCsome.
This
hybrid
nanovehicle
shows
ability
high
targeting
specificity
toward
inflamed
cells,
due
both
good
endothelium
penetration
uptake
cells.
Consequently,
a
single‐dose
administration
MP‐loaded
achieves
prominent
treatment
lipopolysaccharide‐induced
inflammation,
negligible
treatment‐induced
are
observed.
The
provides
powerful
using
solve
current
challenges
intervention.
Abstract
Living
cell‐mediated
nanodelivery
system
is
considered
a
promising
candidate
for
targeted
antitumor
therapy;
however,
their
use
restricted
by
the
adverse
interactions
between
carrier
cells
and
nanocargos.
Herein,
novel
erythrocyte‐based
developed
assembling
renal‐clearable
copper
sulfide
(CuS)
nanodots
on
outer
membranes
of
erythrocytes
via
lipid
fusion
approach,
demonstrate
that
it
an
efficient
photothermal
platform
against
hepatocellular
carcinoma.
After
intravenous
injection
system,
CuS
assembled
can
be
released
from
accumulate
in
tumors
response
to
high
shear
stress
bloodstream,
show
excellent
effect
under
near
infrared
laser
irradiation.
Therefore,
erythrocyte‐mediated
holds
many
advantages
including
prolonged
blood
circulation
duration
enhanced
tumor
accumulation.
Significantly,
elimination
half‐life
74.75
±
8.77
h,
which
much
longer
than
(33.56
2.36
h).
Moreover,
other
two
kinds
well
onto
produce
hitchhiking
platforms.
Together,
findings
promote
not
only
development
systems
as
potential
platforms
treatment
but
also
further
clinical
translation
toward
personalized
healthcare.
Abstract
The
strong
anti‐inflammatory
effect
of
methylprednisolone
(MP)
is
a
necessary
treatment
for
various
severe
cases
including
acute
spinal
cord
injury
(SCI).
However,
concerns
have
been
raised
regarding
adverse
effects
from
MP,
which
also
severely
limits
its
clinical
application.
Natural
polyphenols,
due
to
their
rich
phenolic
hydroxyl
chemical
properties,
can
form
dynamic
structures
without
additional
modification,
achieving
targeted
enrichment
and
drug
release
at
the
disease
lesion,
making
them
highly
promising
carrier.
Considering
application
challenges
natural
polyphenolic
platform
employed
efficient
delivery
reducing
systemic
side
effects.
Both
in
vitro
SCI
models
demonstrated
polyphenols
multiple
advantages
as
carriers
delivering
MP:
(1)
Achieved
maximum
injured
site
2
h
post‐administration,
met
desires
early
diseases;
(2)
Traceless
MP;
(3)
Reducing
effects;
(4)
Endowed
system
with
new
antioxidative
an
aspect
that
needs
be
addressed
diseases
treatment.
This
study
highlighted
prospect
robust
based
on
successfully
overcome
barrier
MP
treatment,
providing
possibility
widespread
