Oral exposure to polystyrene nanoplastics reduced male fertility and even caused male infertility by inducing testicular and sperm toxicities in mice

Journal of Hazardous Materials, Год журнала: 2023, Номер 454, С. 131470 - 131470

Опубликована: Апрель 23, 2023

Язык: Английский

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Microplastics in human blood: Polymer types, concentrations and characterisation using μFTIR

Environment International, Год журнала: 2024, Номер 188, С. 108751 - 108751

Опубликована: Май 14, 2024

Microplastics (MPs) are an everyday part of life, and now ubiquitous in the environment. Crucially, MPs have not just been found within environment, but also human bodies, including blood. We aimed to provide novel information on range MP polymer types present, as well their size shape characteristics, whole blood from 20 healthy volunteers. Twenty-four were identified 18 out (90 %) donors quantified blood, with majority observed for first time. Using LOQ approach, five met threshold a lower mean ± SD 2466 4174 MP/L. The concentrations plastics analysed samples ranged 1.84 - 4.65 μg/mL. Polyethylene (32 %), ethylene propylene diene (14 ethylene-vinyl-acetate/alcohol (12 fragments most abundant. particles that had particle length 127.99 293.26 µm (7-3000 µm), width 57.88 88.89 (5-800 µm). predominantly categorised (88 white/clear (79 %). A variety plastic additive chemicals endocrine disrupting-classed phthalates. procedural blank comprised 7 types, distinct those mainly resin (25 polyethylene terephthalate (17 polystyrene 4.80 5.59 This study adds growing evidence taken up into body transported via bloodstream. sizes raise important questions respect presence associated hazards terms potential detrimental impacts such vascular inflammation, build major organs, changes either immune cell response, or haemostasis thrombosis.

Язык: Английский

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Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage

Particle and Fibre Toxicology, Год журнала: 2024, Номер 21(1)

Опубликована: Март 7, 2024

Abstract Background With rapid increase in the global use of various plastics, microplastics (MPs) and nanoplastics (NPs) pollution their adverse health effects have attracted attention. MPs been detected out human body both NPs showed female reproductive toxicological animal models. Miscarriage (abnormal early embryo loss), accounting for 15-25% pregnant women worldwide, greatly harms reproduction. However, on miscarriage never explored. Results In this study, we identified that polystyrene (PS) plastics particles were present villous tissues. Their levels higher tissues unexplained recurrent (RM) patients vs. healthy control (HC) group. Furthermore, mouse assays further confirmed exposure to (PS-NPs, 50 nm diameter, or 100 mg/kg) indeed induced miscarriage. mechanism, PS-NPs (50, 100, 150, 200 µg/mL) increased oxidative stress, decreased mitochondrial membrane potential, apoptosis trophoblast cells by activating Bcl-2/Cleaved-caspase-2/Cleaved-caspase-3 signaling through pathway. The alteration was consistent placental PS-NPs-exposed model RM patients. Supplement with Bcl-2 could efficiently suppress reduce alleviate model. Conclusions Exposure activated Bcl-2/Cleaved-caspase-2/Cleaved-caspase-3, leading excessive mice tissues, inducing Graphical

Язык: Английский

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Prevalence and implications of microplastic contaminants in general human seminal fluid: A Raman spectroscopic study

The Science of The Total Environment, Год журнала: 2024, Номер 937, С. 173522 - 173522

Опубликована: Май 25, 2024

Язык: Английский

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Toxicological Research on Nano and Microplastics in Environmental Pollution: Current Advances and Future Directions

Aquatic Toxicology, Год журнала: 2024, Номер 270, С. 106894 - 106894

Опубликована: Март 11, 2024

Язык: Английский

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Chronic exposure to tire rubber-derived contaminant 6PPD-quinone impairs sperm quality and induces the damage of reproductive capacity in male mice

Journal of Hazardous Materials, Год журнала: 2024, Номер 470, С. 134165 - 134165

Опубликована: Март 28, 2024

Язык: Английский

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The hidden threat: Unraveling the impact of microplastics on reproductive health

The Science of The Total Environment, Год журнала: 2024, Номер 935, С. 173177 - 173177

Опубликована: Май 13, 2024

Язык: Английский

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Beyond the cradle – Amidst microplastics and the ongoing peril during pregnancy and neonatal stages: A holistic review

Journal of Hazardous Materials, Год журнала: 2024, Номер 469, С. 133963 - 133963

Опубликована: Март 6, 2024

Язык: Английский

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Polylactic Acid Micro/Nanoplastic Exposure Induces Male Reproductive Toxicity by Disrupting Spermatogenesis and Mitochondrial Dysfunction in Mice

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Although considered an "eco-friendly" biodegradable plastic, polylactic acid (PLA) microplastic (PLA-MP) poses a growing concern for human health, yet its effects on male reproductive function remain underexplored. This study investigated the toxicity of PLA in mice and potential mechanisms. To this end, our vivo vitro experiments demonstrated that after degradation digestive system, significant number PLA-MP-derived nanoparticles could penetrate blood–testis barrier (BTB) localize within spermatogenic microenvironment. Mice exposed to PLA-MPs long time exhibited toxicity, evidenced by decreased sperm concentration motility, increased deformity rates, disrupted sex hormone levels. Further analysis revealed impaired BTB, induced mitochondrial dysfunction testes, triggered oxidative stress through excessive ROS production from mitochondria, leading further testicular damage. Notably, nanoplastics internalized sheath structure sperm, causing dose-dependent impairments function. Transcriptome analyses indicated spermatogenesis inhibiting expression key mRNA involved process. Collectively, findings highlight toxic effect damaging BTB impairing function, which provides insights into toxicological implications microplastics mammalian fertility.

Язык: Английский

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The histopathological and functional consequences of microplastic exposure

Deleted Journal, Год журнала: 2025, Номер 7(1)

Опубликована: Янв. 11, 2025

As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory, nervous, digestive, respiratory, reproductive systems explains associated functional alterations. Except nervous system, main morphological involve degenerative throughout body, such as apoptosis, inflammation, fibrosis. Most were inflammatory responses microplastics, leading fibrosis subsequent impairments. Various studies confirm that stimulate cells, increased reactive oxygen species cell death. Consequently, these impair related systemic functions. review highlights fundamental organs cells due discusses limitations involving showing no changes.

Язык: Английский

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