Natural Antioxidants from Plant Extracts in Skincare Cosmetics: Recent Applications, Challenges and Perspectives

Cosmetics, Год журнала: 2021, Номер 8(4), С. 106 - 106

Опубликована: Ноя. 10, 2021

In recent years, interest in the health effects of natural antioxidants has increased due to their safety and applicability cosmetic formulation. Nevertheless, efficacy vivo is less documented than prooxidant properties vivo. Plant extracts rich vitamins, flavonoids, phenolic compounds can induce oxidative damage by reacting with various biomolecules while also providing antioxidant properties. Because biological activities differ, effectiveness for slowing aging process remains unclear. This review article focuses on use skincare possible mechanisms underlying desired effect, along applications formulation limitations.

Язык: Английский

---

Comprehensive Metabolite Profiling of Berdav Propolis Using LC-MS/MS: Determination of Antioxidant, Anticholinergic, Antiglaucoma, and Antidiabetic Effects

Molecules, Год журнала: 2023, Номер 28(4), С. 1739 - 1739

Опубликована: Фев. 11, 2023

Propolis is a complex natural compound that honeybees obtain from plants and contributes to hive safety. It rich in phenolic flavonoid compounds, which contain antioxidant, antimicrobial, anticancer properties. In this study, the chemical composition antioxidant activities of propolis were investigated; ABTS

Язык: Английский

---

Recent advances in the extraction, composition analysis and bioactivity of Camellia (Camellia oleifera Abel.) oil

Trends in Food Science & Technology, Год журнала: 2023, Номер 143, С. 104211 - 104211

Опубликована: Окт. 20, 2023

Язык: Английский

---

Multifunctional lipid-based nanoparticles for wound healing and antibacterial applications: A review

Advances in Colloid and Interface Science, Год журнала: 2023, Номер 321, С. 103002 - 103002

Опубликована: Сен. 27, 2023

Wound healing primarily involves preventing severe infections, accelerating healing, and reducing pain scarring. Therefore, the multifunctional application of lipid-based nanoparticles (LBNs) has received considerable attention in drug discovery due to their solid or liquid lipid core, which increases ability provide prolonged release, reduce treatment costs, improve patient compliance. LBNs have also been used medical cosmetic practices formulated for various products based on skin type, disease conditions, administration product efficiency, stability, toxicity; therefore, understanding interaction with biological systems is very important. it necessary perform an in-depth analysis results from a comprehensive characterization process produce delivery desired properties. This review will detailed information different types LBNs, formulation methods, characterisation, antimicrobial activity, wound models (both vitro vivo studies). Also, clinical commercial applications are summarized.

Язык: Английский

---

Potential of nanoemulsions for accelerated wound healing: innovative strategies

International Journal of Surgery, Год журнала: 2023, Номер 109(8), С. 2365 - 2377

Опубликована: Май 9, 2023

Wounds represent various significant health concerns for patients and also contribute major costs to healthcare systems. Wound healing comprises of overlapped coordinated steps such as homeostasis, inflammation, proliferation, remodeling. In response the failure many strategies in delivering intended results including wound closure, fluid loss control, exhibiting properties durability, targeted delivery, accelerated action, along with histocompatibility, numerous nanotechnological advances have been introduced. To understand magnitude therapy, this systematic updated review discussing effectiveness nanoemulsions has undertaken. This portrays mechanisms associated healing, factors delayed technologies utilized treat wounds effectively. While are available, attracted tremendous attention scientists globally research therapy due their long-term thermodynamic stability bioavailability. Nanoemulsions not only aid tissue repair, but considered an excellent delivery system synthetic natural actives. Nanotechnology provides several pivotal benefits improved skin permeation, controlled release, stimulation fibroblast cell proliferation. The role preparation techniques highlighted special emphasis on mechanistic insights. article illustrates recent advancements utilization treatment. An adequate literature search conducted using keywords ‘Nanoemulsions healing’, ‘Wound nanoemulsions’, ‘Herbal actives therapy’, ‘Natural oils treatment’ etc., from PubMed, Science Direct, Google Scholar databases. Referred original publications English language accessed till April 2022 included, whereas nonEnglish papers, unpublished data, nonoriginal papers were excluded study.

Язык: Английский

---

Development of collagen–chitosan dressing gel functionalized with propolis–zinc oxide nanoarchitectonics to accelerate wound healing

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 261, С. 129665 - 129665

Опубликована: Янв. 23, 2024

Язык: Английский

---

Antimicrobial peptides as antimicrobials for wound care management: A comprehensive review

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 95, С. 105570 - 105570

Опубликована: Март 12, 2024

Язык: Английский

---

The essential oil of Melaleuca alternifolia incorporated into hydrogel induces antimicrobial and anti-inflammatory effects on infected wounds by Staphylococcus aureus

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 173, С. 116389 - 116389

Опубликована: Март 11, 2024

Staphylococcus aureus is one of the most common bacterial isolates found in wounds. Thus, innovative dressings, such as hydrogels, are interesting vehicles for incorporating bioactive compounds like those from Melaleuca alternifolia essential oil (MaEO). In this study, we evaluated antimicrobial and anti-inflammatory potential MaEO incorporated into an alginate chitosan hydrogel treating wounds infected by S. aureus. The with 1% (HMa 1%) was homogeneous a bright pale-yellow color characteristic smell Melaleuca. incorporation does not affect stability hydrogel, which stable up to 90 days storage. Scanning electron microscopy analysis revealed that hydrogels showed irregular surfaces interconnected porous structures accumulations crystals distributed throughout formulation. HMa has high moisture content (95.1%) can absorb simulated wound fluid. Regarding effects, reduced growth ATCC 6538 both vitro conditions ex vivo model using porcine skin. addition, dairy topical treatment murine skin lesions induced significant reduction area, inflammation score, load, well tissue re-epithelialization modulation inflammatory mediators. Therefore, excellent be used pharmacotherapy

Язык: Английский

---

Optimized Hesperidin-Loaded Lipid Nanoparticles with Tea Tree Oil for Enhanced Wound Healing: Formulation, Characterization, and Evaluation

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 290 - 290

Опубликована: Фев. 20, 2025

Objectives: This study aimed to develop hesperidin solid lipid nanoparticles (HESP-SLNs) enhance their stability, solubility, and sustained release for wound healing; further enhancement was achieved through prepared nanostructured carriers (HESP-NLCs) using Tea Tree Oil (TTO) explore synergistic efficacy. Methods: A factorial design of 24 trials established evaluate the influence type (X1), conc (%) (X2), surfactant (X3), sonication amplitude (X4) HESP-SLNs on particle size (nm) (Y1), polydispersibility index (Y2), zeta potential (Y3), encapsulation efficiency (Y4). The optimized formula selected utilizing Design Expert® software version 13, which additionally enhanced by preparing TTO-loaded HESP-NLCs. In vitro release, Raman spectroscopy, transmission electron microscopy were carried out both nanoparticles. Cytotoxicity, in vivo wound-healing assessments, skin irritancy tests performed performance TTO-incorporated HESP-NLCs compared HESP-SLNs. Results: demonstrated PS (280 ± 1.35 nm), ZP (−39.4 0.92 mV), PDI (0.239 0.012), EE% (88.2 2.09%). NLCs Q6% (95.14%) vs. (79.69%), SLNs showed superior antimicrobial Both exhibited spherical morphology compatibility between HESP excipients. highest closure percentage, supported histological analysis inflammatory biomarker outcomes. Cytotoxicity evaluation 87% cell viability untreated HSF cells, test confirmed safety NLCs. Conclusions: are promising candidates exhibiting capabilities, making them a therapeutic option cutaneous management.

Язык: Английский

---

Utilization of propranolol hydrochloride mucoadhesive invasomes as a locally acting contraceptive: in-vitro, ex-vivo, and in-vivo evaluation

Drug Delivery, Год журнала: 2022, Номер 29(1), С. 2549 - 2560

Опубликована: Июль 31, 2022

It was found that propranolol hydrochloride (PNL), which is a beta-blocker used for hypertension treatment, has potent spermicidal activity through local anesthetic or beta-blocking effect on sperm cells subsequently it could be as contraceptive remedy. This study aimed to entrap PNL into invasomes (INVs) and then formulate locally acting gel. PNL-loaded mucoadhesive INVs were prepared via the thin-film hydration technique. The D-optimal design utilized fabricate employing lipid concentration (X1), terpenes (X2), type (X3), chitosan (X4) independent variables, while their impact observed entrapment efficiency percent (Y1; EE%), particle size (Y2; PS), zeta potential (Y3; ZP), amount of drug released after 6 h (Y4; Q6h). Design Expert® bestowed nominate desired formula. selected INV subjected further studies formulated gel ex-vivo in-vivo investigations. optimum showed spherical shape with EE% 65.01 ± 1.24%, PS 243.75 8.13 nm, PDI 0.203 0.01, ZP 49.80 0.42 mV, Q6h 53.16 0.73%. Differential scanning calorimetry asserted capability PNL. Permeation confirmed sustained INVs-gel compared PNL-gel, INVs, solution. Sperm motility assay proved potency inhibit motility. Besides, histopathological investigation verified tolerability INVs-gel. Taken together, gained data justified efficacy contraceptive.

Язык: Английский

---