Pseudo ternary phase diagram based PEGylated nano-dispersion of linezolid to promote wound regeneration: An in vitro and in vivo evaluation DOI
Bani Kumar Jana,

Ishita Singha,

Nusalu Puro

et al.

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: Feb. 1, 2025

Open wounds are prone to bacterial infiltration mostly resistant strains like methicillin-resistant Staphylococcus aureus (MRSA), which affects healing of open wounds. Topical linezolid nano-dispersion using essential oils as nanoemulgel can increase solubility drug and bypass side-effects GI-irritation oral administration. Pseudo-ternary phase diagram was built optimise nanoemulsion. Surfactant/co-surfactant mixture (3:1), deionised water Oilmix (4:1) with were vortexed then ultrasonicated. 1% carbopol gel optimised nanoemulsion prepared characterised, exposed antimicrobial study, cytocompatibility study HEK293 cell-line, in vivo wound rat excision model. Histological performed confirm growth stratum corneum. Optimised formulation has particle size (244.6 ± 178.66 nm), polydispersity index (25%), entrapment efficiency (92.3 3.38%) vitro release (87.58 4.16%) best fitted Korsmeyer-Peppas kinetics Nanoemulgel F6 (0.2%w/w) found viscosity 5345 6 cP constituting a very excellent effect against MRSA. cells had shown good formulation. The contraction rate 99.66 0.57% at day 15 on daily application corneum almost fully regenerated. developed potential efficacy promote healing.

Language: Английский

Natural Antioxidants from Plant Extracts in Skincare Cosmetics: Recent Applications, Challenges and Perspectives DOI Creative Commons

Hien Thi Hoang,

Ju‐Young Moon,

Young‐Chul Lee

et al.

Cosmetics, Journal Year: 2021, Volume and Issue: 8(4), P. 106 - 106

Published: Nov. 10, 2021

In recent years, interest in the health effects of natural antioxidants has increased due to their safety and applicability cosmetic formulation. Nevertheless, efficacy vivo is less documented than prooxidant properties vivo. Plant extracts rich vitamins, flavonoids, phenolic compounds can induce oxidative damage by reacting with various biomolecules while also providing antioxidant properties. Because biological activities differ, effectiveness for slowing aging process remains unclear. This review article focuses on use skincare possible mechanisms underlying desired effect, along applications formulation limitations.

Language: Английский

Citations

195
Comprehensive Metabolite Profiling of Berdav Propolis Using LC-MS/MS: Determination of Antioxidant, Anticholinergic, Antiglaucoma, and Antidiabetic Effects DOI Creative Commons
Hasan Karageçili, Mustafa Abdullah Yılmaz, Adem Ertürk

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(4), P. 1739 - 1739

Published: Feb. 11, 2023

Propolis is a complex natural compound that honeybees obtain from plants and contributes to hive safety. It rich in phenolic flavonoid compounds, which contain antioxidant, antimicrobial, anticancer properties. In this study, the chemical composition antioxidant activities of propolis were investigated; ABTS

Language: Английский

Citations

84
Recent advances in the extraction, composition analysis and bioactivity of Camellia (Camellia oleifera Abel.) oil DOI
Lu Gao,

Lihua Jin,

Qiannan Liu

et al.

Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 143, P. 104211 - 104211

Published: Oct. 20, 2023

Language: Английский

Citations

48
Multifunctional lipid-based nanoparticles for wound healing and antibacterial applications: A review DOI Creative Commons

Fezile Motsoene,

Heidi Abrahamse, Sathish Sundar Dhilip Kumar

et al.

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 321, P. 103002 - 103002

Published: Sept. 27, 2023

Wound healing primarily involves preventing severe infections, accelerating healing, and reducing pain scarring. Therefore, the multifunctional application of lipid-based nanoparticles (LBNs) has received considerable attention in drug discovery due to their solid or liquid lipid core, which increases ability provide prolonged release, reduce treatment costs, improve patient compliance. LBNs have also been used medical cosmetic practices formulated for various products based on skin type, disease conditions, administration product efficiency, stability, toxicity; therefore, understanding interaction with biological systems is very important. it necessary perform an in-depth analysis results from a comprehensive characterization process produce delivery desired properties. This review will detailed information different types LBNs, formulation methods, characterisation, antimicrobial activity, wound models (both vitro vivo studies). Also, clinical commercial applications are summarized.

Language: Английский

Citations

28
Potential of nanoemulsions for accelerated wound healing: innovative strategies DOI Creative Commons

Jatin Chhabra,

Hitesh Chopra, Rakesh Pahwa

et al.

International Journal of Surgery, Journal Year: 2023, Volume and Issue: 109(8), P. 2365 - 2377

Published: May 9, 2023

Wounds represent various significant health concerns for patients and also contribute major costs to healthcare systems. Wound healing comprises of overlapped coordinated steps such as homeostasis, inflammation, proliferation, remodeling. In response the failure many strategies in delivering intended results including wound closure, fluid loss control, exhibiting properties durability, targeted delivery, accelerated action, along with histocompatibility, numerous nanotechnological advances have been introduced. To understand magnitude therapy, this systematic updated review discussing effectiveness nanoemulsions has undertaken. This portrays mechanisms associated healing, factors delayed technologies utilized treat wounds effectively. While are available, attracted tremendous attention scientists globally research therapy due their long-term thermodynamic stability bioavailability. Nanoemulsions not only aid tissue repair, but considered an excellent delivery system synthetic natural actives. Nanotechnology provides several pivotal benefits improved skin permeation, controlled release, stimulation fibroblast cell proliferation. The role preparation techniques highlighted special emphasis on mechanistic insights. article illustrates recent advancements utilization treatment. An adequate literature search conducted using keywords ‘Nanoemulsions healing’, ‘Wound nanoemulsions’, ‘Herbal actives therapy’, ‘Natural oils treatment’ etc., from PubMed, Science Direct, Google Scholar databases. Referred original publications English language accessed till April 2022 included, whereas nonEnglish papers, unpublished data, nonoriginal papers were excluded study.

Language: Английский

Citations

23
Development of collagen–chitosan dressing gel functionalized with propolis–zinc oxide nanoarchitectonics to accelerate wound healing DOI
Heba S. Zayed, Safaa Saleh,

Areg E. Omar

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129665 - 129665

Published: Jan. 23, 2024

Language: Английский

Citations

12
Antimicrobial peptides as antimicrobials for wound care management: A comprehensive review DOI
Kunal Agam Kanaujia, Nidhi Mishra,

P.S. Rajinikanth

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105570 - 105570

Published: March 12, 2024

Language: Английский

Citations

12
The essential oil of Melaleuca alternifolia incorporated into hydrogel induces antimicrobial and anti-inflammatory effects on infected wounds by Staphylococcus aureus DOI Creative Commons
Beatriz Gomes Vila Nova, Lucas dos Santos Silva, Marcos Andrade Silva

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116389 - 116389

Published: March 11, 2024

Staphylococcus aureus is one of the most common bacterial isolates found in wounds. Thus, innovative dressings, such as hydrogels, are interesting vehicles for incorporating bioactive compounds like those from Melaleuca alternifolia essential oil (MaEO). In this study, we evaluated antimicrobial and anti-inflammatory potential MaEO incorporated into an alginate chitosan hydrogel treating wounds infected by S. aureus. The with 1% (HMa 1%) was homogeneous a bright pale-yellow color characteristic smell Melaleuca. incorporation does not affect stability hydrogel, which stable up to 90 days storage. Scanning electron microscopy analysis revealed that hydrogels showed irregular surfaces interconnected porous structures accumulations crystals distributed throughout formulation. HMa has high moisture content (95.1%) can absorb simulated wound fluid. Regarding effects, reduced growth ATCC 6538 both vitro conditions ex vivo model using porcine skin. addition, dairy topical treatment murine skin lesions induced significant reduction area, inflammation score, load, well tissue re-epithelialization modulation inflammatory mediators. Therefore, excellent be used pharmacotherapy

Language: Английский

Citations

9
Optimized Hesperidin-Loaded Lipid Nanoparticles with Tea Tree Oil for Enhanced Wound Healing: Formulation, Characterization, and Evaluation DOI Creative Commons
Borros Arneth, Rehab Abdelmonem, Mohamed A. El-Nabarawi

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 290 - 290

Published: Feb. 20, 2025

Objectives: This study aimed to develop hesperidin solid lipid nanoparticles (HESP-SLNs) enhance their stability, solubility, and sustained release for wound healing; further enhancement was achieved through prepared nanostructured carriers (HESP-NLCs) using Tea Tree Oil (TTO) explore synergistic efficacy. Methods: A factorial design of 24 trials established evaluate the influence type (X1), conc (%) (X2), surfactant (X3), sonication amplitude (X4) HESP-SLNs on particle size (nm) (Y1), polydispersibility index (Y2), zeta potential (Y3), encapsulation efficiency (Y4). The optimized formula selected utilizing Design Expert® software version 13, which additionally enhanced by preparing TTO-loaded HESP-NLCs. In vitro release, Raman spectroscopy, transmission electron microscopy were carried out both nanoparticles. Cytotoxicity, in vivo wound-healing assessments, skin irritancy tests performed performance TTO-incorporated HESP-NLCs compared HESP-SLNs. Results: demonstrated PS (280 ± 1.35 nm), ZP (−39.4 0.92 mV), PDI (0.239 0.012), EE% (88.2 2.09%). NLCs Q6% (95.14%) vs. (79.69%), SLNs showed superior antimicrobial Both exhibited spherical morphology compatibility between HESP excipients. highest closure percentage, supported histological analysis inflammatory biomarker outcomes. Cytotoxicity evaluation 87% cell viability untreated HSF cells, test confirmed safety NLCs. Conclusions: are promising candidates exhibiting capabilities, making them a therapeutic option cutaneous management.

Language: Английский

Citations

1
Utilization of propranolol hydrochloride mucoadhesive invasomes as a locally acting contraceptive: in-vitro, ex-vivo, and in-vivo evaluation DOI Creative Commons
Mahmoud H. Teaima, Moaz A. Eltabeeb, Mohamed A. El-Nabarawi

et al.

Drug Delivery, Journal Year: 2022, Volume and Issue: 29(1), P. 2549 - 2560

Published: July 31, 2022

It was found that propranolol hydrochloride (PNL), which is a beta-blocker used for hypertension treatment, has potent spermicidal activity through local anesthetic or beta-blocking effect on sperm cells subsequently it could be as contraceptive remedy. This study aimed to entrap PNL into invasomes (INVs) and then formulate locally acting gel. PNL-loaded mucoadhesive INVs were prepared via the thin-film hydration technique. The D-optimal design utilized fabricate employing lipid concentration (X1), terpenes (X2), type (X3), chitosan (X4) independent variables, while their impact observed entrapment efficiency percent (Y1; EE%), particle size (Y2; PS), zeta potential (Y3; ZP), amount of drug released after 6 h (Y4; Q6h). Design Expert® bestowed nominate desired formula. selected INV subjected further studies formulated gel ex-vivo in-vivo investigations. optimum showed spherical shape with EE% 65.01 ± 1.24%, PS 243.75 8.13 nm, PDI 0.203 0.01, ZP 49.80 0.42 mV, Q6h 53.16 0.73%. Differential scanning calorimetry asserted capability PNL. Permeation confirmed sustained INVs-gel compared PNL-gel, INVs, solution. Sperm motility assay proved potency inhibit motility. Besides, histopathological investigation verified tolerability INVs-gel. Taken together, gained data justified efficacy contraceptive.

Language: Английский

Citations

31