Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 25, 2024
The
rapid
development
of
self-assembly
technology
during
the
past
few
decades
has
effectively
addressed
plenty
issues
associated
with
carrier-based
drug
delivery
systems,
such
as
low
loading
efficiency,
complex
fabrication
processes,
and
inherent
toxicity
carriers.
integration
nanoscale
systems
techniques
enabled
efficient
targeted
self-administration
drugs,
enhanced
bioavailability,
prolonged
circulation
time,
controllable
release.
Concurrently,
limitations
single-mode
cancer
treatment,
including
poor
therapeutic
outcomes,
significant
side
effects,
have
highlighted
urgent
need
for
multimodal
combined
antitumor
therapies.
Set
against
backdrop
therapy,
this
review
summarizes
research
progress
applications
a
large
number
self-assembled
platforms,
natural
small
molecule
self-assembled,
carrier-free
amphiphilic
polymer-based
peptide-based
metal-based
nano
systems.
This
particularly
analyzes
latest
advances
in
application
platforms
therapies
mediated
by
chemotherapy,
phototherapy,
radiotherapy,
sonodynamic
immunotherapy,
providing
innovative
insights
further
optimization
expansion
clinical
translation
therapy.
Nano Letters,
Год журнала:
2024,
Номер
24(22), С. 6767 - 6777
Опубликована: Май 21, 2024
Efforts
to
prolong
the
blood
circulation
time
and
bypass
immune
clearance
play
vital
roles
in
improving
therapeutic
efficacy
of
nanoparticles
(NPs).
Herein,
a
multifunctional
nanoplatform
(BPP@RTL)
that
precisely
targets
tumor
cells
is
fabricated
by
encapsulating
ultrasmall
phototherapeutic
agent
black
phosphorus
quantum
dot
(BPQD),
chemotherapeutic
drug
paclitaxel
(PTX),
immunomodulator
PolyMetformin
(PM)
hybrid
membrane-camouflaged
liposomes.
Specifically,
cell
membrane
coating
derived
from
fusion
cancer
red
displays
excellent
targeting
efficiency
long
property
due
innate
features
both
membranes.
After
collaboration
with
aPD-L1-based
checkpoint
blockade
therapy,
boosted
immunotherapeutic
effect
obtained
elevated
dendritic
maturation
T
activation.
Significantly,
laser-irradiated
BPP@RTL
combined
aPD-L1
effectively
eliminates
primary
tumors
inhibits
lung
metastasis
4T1
breast
model,
offering
promising
treatment
plan
develop
personalized
antitumor
strategy.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(22)
Опубликована: Май 16, 2024
Abstract
Chemodynamic
therapy
(CDT)
has
emerged
as
a
transformative
paradigm
in
the
realm
of
reactive
oxygen
species
‐mediated
cancer
therapies,
exhibiting
its
potential
sophisticated
strategy
for
precise
and
effective
tumor
treatment.
CDT
primarily
relies
on
metal
ions
hydrogen
peroxide
to
initiate
Fenton
or
Fenton‐like
reactions,
generating
cytotoxic
hydroxyl
radicals.
Its
notable
advantages
treatment
are
demonstrated,
including
specificity,
autonomy
from
external
triggers,
favorable
side‐effect
profile.
Recent
advancements
nanomedicine
devoted
enhancing
CDT,
promising
comprehensive
optimization
efficacy.
This
review
systematically
elucidates
cutting‐edge
achievements
chemodynamic
nanotherapeutics,
exploring
strategies
enhanced
improved
microenvironment
modulation,
regulation
energy
metabolism.
Moreover,
detailed
analysis
diverse
CDT‐mediated
combination
therapies
is
provided.
Finally,
concludes
with
discussion
prospects
intrinsic
challenges
application
nanotherapeutics
domain
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 15, 2024
Exploring
effective
antibacterial
approaches
for
targeted
treatment
of
pathogenic
bacterial
infections
with
reduced
drug
resistance
is
great
significance.
Combinational
modality
that
leverages
different
therapeutic
components
can
improve
the
overall
effectiveness
and
minimize
adverse
effects,
thus
displaying
considerable
potential
against
infections.
Herein,
red
blood
cell
membrane
fuses
macrophage
to
develop
hybrid
shell,
which
further
camouflages
around
drug-loaded
liposome
fabricate
biomimetic
(AB@LRM)
precise
therapy.
Specifically,
photoactive
agent
black
phosphorus
quantum
dots
(BPQDs)
classical
antibiotics
amikacin
(AM)
are
loaded
in
AB@LRM
accurately
target
inflammatory
sites
through
guidance
long
residence
capability
membrane,
eventually
exerting
efficacious
activities.
Besides,
due
excellent
photothermal
photodynamic
properties,
BPQDs
act
as
an
efficient
when
exposed
near-infrared
laser
irradiation,
dramatically
increasing
sensitivity
bacteria
antibiotics.
Consequently,
synergistic
sterilizing
effect
produced
by
restricts
resistance.
Upon
shows
superior
anti-inflammatory
properties
models
P.
aeruginosa-infected
pneumonia
wounds.
Hence,
this
light-activatable
nanoplatform
good
biocompatibility
presents
advance
clinical
development
cGAS-STING
pathway
activation
has
attracted
considerable
attention
in
antitumor
immunotherapy,
but
clinical
outcomes
lag
behind
expectations
due
to
overlooked
negative
feedback
mechanisms.
Here,
we
determine
that
STING
promotes
tumor
stemness,
which
weakens
the
efficacy
of
STING-based
therapies,
presenting
a
double-edged
sword.
To
address
this
therapeutic
paradox,
simple
metal-phenolic
polymeric
micelle
(HMQ)
was
developed,
Mn2+
(a
agonist)
is
coordinated
with
quercetin
stemness
inhibitor)
and
hyaluronic
acid
(HA),
unlock
full
potential
pathway.
This
unique
coordination
structure
integrates
active
targeting
rapid
pH-responsive
drug
release.
Importantly,
released
drugs
remained
their
original
form,
avoiding
changes
bioactivity.
HMQ
effectively
mitigates
stemness-promoting
effects
activation,
thus
significantly
amplifying
potency
cGAS-STING-based
therapies.
intelligent
facile
establishes
new
generation
agonists
promising
translatability
provides
flexible
platform
for
win–win
strategy.
