Neuroscience, Год журнала: 2022, Номер 497, С. 282 - 307
Опубликована: Май 4, 2022
Язык: Английский
Frontiers in Aging Neuroscience, Год журнала: 2021, Номер 12
Опубликована: Янв. 18, 2021
Previous studies showed that quarantine for pandemic diseases is associated with several psychological and medical effects. The consequences of COVID-19 in patients dementia are unknown. We investigated the clinical changes Alzheimer's disease other dementias, evaluated caregivers' distress during quarantine.
Язык: Английский
Процитировано
127
Neuron, Год журнала: 2022, Номер 110(9), С. 1450 - 1467
Опубликована: Март 21, 2022
Язык: Английский
Процитировано
120
Molecular Psychiatry, Год журнала: 2023, Номер 29(1), С. 20 - 34
Опубликована: Янв. 4, 2023
Язык: Английский
Процитировано
85
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 162, С. 114647 - 114647
Опубликована: Апрель 1, 2023
With rapid aging of the population worldwide, number people with dementia is dramatically increasing. Some studies have emphasized that metabolic syndrome, which includes obesity and diabetes, leads to increased risks cognitive decline. Factors such as insulin resistance, hyperglycemia, high blood pressure, dyslipidemia, central in syndrome are associated synaptic failure, neuroinflammation, imbalanced neurotransmitter levels, leading progression dementia. Due positive correlation between diabetes dementia, some called it "type 3 diabetes". Recently, patients decline due imbalances has considerably increased. In addition, recent reported neuropsychiatric issues anxiety, depressive behavior, impaired attention common factors disease those nervous system (CNS), amygdala a region regulates emotional memory, mood disorders, attention, function. The connectivity other brain regions, hippocampus, activity contribute diverse neuropathological issues. Thus, this review summarizes significant consequences critical roles both syndromes Further on function imbalance-related needed treat problems type
Язык: Английский
Процитировано
26
Perspectives on Psychological Science, Год журнала: 2023, Номер 19(1), С. 103 - 125
Опубликована: Июнь 30, 2023
The multiple-memory-systems framework-that distinct types of memory are supported by brain systems-has guided learning and research for decades. However, recent work challenges the one-to-one mapping between structures central to this taxonomy, with key memory-related supporting multiple functions across substructures. Here we integrate cross-species findings in hippocampus, striatum, amygdala propose an updated framework subsystems (MMSS). We provide evidence two organizational principles MMSS theory: First, opposing representations colocated same structures; second, parallel structures. discuss why burgeoning has potential a useful revision classic theories long-term memory, what is needed further validate framework, how novel perspective on organization may guide future research.
Язык: Английский
Процитировано
23
Cell, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
11
Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 147, С. 105101 - 105101
Опубликована: Фев. 17, 2023
Язык: Английский
Процитировано
18
European Journal of Neuroscience, Год журнала: 2021, Номер 55(9-10), С. 2491 - 2518
Опубликована: Март 16, 2021
Stressful experiences evoke, among others, a rapid increase in brain (nor)epinephrine (NE) levels and slower glucocorticoid hormones (GCs) the brain. Microglia are key regulators of neuronal function contain receptors for NE GCs. These cells may therefore potentially be involved modulating stress effects on learning memory. In this review, we discuss that induces (1) an microglial numbers as well (2) shift toward pro-inflammatory profile. microglia have (3) impaired crosstalk with neurons (4) disrupted glutamate signaling. Moreover, immune responses after (5) alter kynurenine pathway through metabolites impair glutamatergic transmission. All these could impairments memory synaptic plasticity caused by (prolonged) stress, implicating potential novel target stress-related impairments.
Язык: Английский
Процитировано
36
Neuroscience & Biobehavioral Reviews, Год журнала: 2022, Номер 142, С. 104901 - 104901
Опубликована: Окт. 10, 2022
Stress hormones influence the processing of fear, anxiety, and related memory mechanisms. For example, they modulate consolidation retrieval processes associated with emotional episodic memory, fear extinction learning. In this review, we summarize recent laboratory findings on timing-dependent effects stress learning retrieval. Furthermore, relate these experiments to clinical intervention approaches relying such as exposure therapy, for which beneficial administration hormone cortisol have been observed. The modulation extinction-based interventions differs from obtained reconsolidation manipulation procedures utilizing restabilization retrieved (or reactivated) memories. case, blockade adrenergic beta-receptors during fearful stimulus might represent a promising intervention. substantial progress made in understanding interaction anxiety has potential enhance therapeutic success prevent relapse long run.
Язык: Английский
Процитировано
24
International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(18), С. 9806 - 9806
Опубликована: Сен. 10, 2021
A growing body of evidence suggests that nucleus accumbens (NAc) plays a significant role not only in the physiological processes associated with reward and satisfaction but also many diseases central nervous system. Summary current state knowledge on morphological functional basis such diverse function this structure may be good starting point for further basic clinical research. The NAc is part brain system (BRS) characterized by multilevel organization, extensive connections, several neurotransmitter systems. unique BRS result of: (1) hierarchical connections other areas, (2) well-developed plasticity regulating short- long-term synaptic potentiation signalling pathways, (3) cooperation among systems, (4) supportive neuroglia involved both pathological processes. Understanding complex possible combining results studies molecular, genetic, behavioral data. In review, we present views conditions, emphasizing its neuroplasticity processes,
Язык: Английский
Процитировано
31