The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey

Frontiers in Aging Neuroscience, Journal Year: 2021, Volume and Issue: 12

Published: Jan. 18, 2021

Previous studies showed that quarantine for pandemic diseases is associated with several psychological and medical effects. The consequences of COVID-19 in patients dementia are unknown. We investigated the clinical changes Alzheimer's disease other dementias, evaluated caregivers' distress during quarantine.

Language: Английский

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Mechanisms of memory under stress

Neuron, Journal Year: 2022, Volume and Issue: 110(9), P. 1450 - 1467

Published: March 21, 2022

Language: Английский

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The cortisol switch between vulnerability and resilience

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 29(1), P. 20 - 34

Published: Jan. 4, 2023

Language: Английский

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Amygdala activity and amygdala-hippocampus connectivity: Metabolic diseases, dementia, and neuropsychiatric issues

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114647 - 114647

Published: April 1, 2023

With rapid aging of the population worldwide, number people with dementia is dramatically increasing. Some studies have emphasized that metabolic syndrome, which includes obesity and diabetes, leads to increased risks cognitive decline. Factors such as insulin resistance, hyperglycemia, high blood pressure, dyslipidemia, central in syndrome are associated synaptic failure, neuroinflammation, imbalanced neurotransmitter levels, leading progression dementia. Due positive correlation between diabetes dementia, some called it "type 3 diabetes". Recently, patients decline due imbalances has considerably increased. In addition, recent reported neuropsychiatric issues anxiety, depressive behavior, impaired attention common factors disease those nervous system (CNS), amygdala a region regulates emotional memory, mood disorders, attention, function. The connectivity other brain regions, hippocampus, activity contribute diverse neuropathological issues. Thus, this review summarizes significant consequences critical roles both syndromes Further on function imbalance-related needed treat problems type

Language: Английский

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Multiple Memory Subsystems: Reconsidering Memory in the Mind and Brain

Perspectives on Psychological Science, Journal Year: 2023, Volume and Issue: 19(1), P. 103 - 125

Published: June 30, 2023

The multiple-memory-systems framework-that distinct types of memory are supported by brain systems-has guided learning and research for decades. However, recent work challenges the one-to-one mapping between structures central to this taxonomy, with key memory-related supporting multiple functions across substructures. Here we integrate cross-species findings in hippocampus, striatum, amygdala propose an updated framework subsystems (MMSS). We provide evidence two organizational principles MMSS theory: First, opposing representations colocated same structures; second, parallel structures. discuss why burgeoning has potential a useful revision classic theories long-term memory, what is needed further validate framework, how novel perspective on organization may guide future research.

Language: Английский

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Stress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice

Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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On making (and turning adaptive to) maladaptive aversive memories in laboratory rodents

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 147, P. 105101 - 105101

Published: Feb. 17, 2023

Language: Английский

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An emerging role for microglia in stress‐effects on memory

European Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 55(9-10), P. 2491 - 2518

Published: March 16, 2021

Stressful experiences evoke, among others, a rapid increase in brain (nor)epinephrine (NE) levels and slower glucocorticoid hormones (GCs) the brain. Microglia are key regulators of neuronal function contain receptors for NE GCs. These cells may therefore potentially be involved modulating stress effects on learning memory. In this review, we discuss that induces (1) an microglial numbers as well (2) shift toward pro-inflammatory profile. microglia have (3) impaired crosstalk with neurons (4) disrupted glutamate signaling. Moreover, immune responses after (5) alter kynurenine pathway through metabolites impair glutamatergic transmission. All these could impairments memory synaptic plasticity caused by (prolonged) stress, implicating potential novel target stress-related impairments.

Language: Английский

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How stress hormones shape memories of fear and anxiety in humans

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 142, P. 104901 - 104901

Published: Oct. 10, 2022

Stress hormones influence the processing of fear, anxiety, and related memory mechanisms. For example, they modulate consolidation retrieval processes associated with emotional episodic memory, fear extinction learning. In this review, we summarize recent laboratory findings on timing-dependent effects stress learning retrieval. Furthermore, relate these experiments to clinical intervention approaches relying such as exposure therapy, for which beneficial administration hormone cortisol have been observed. The modulation extinction-based interventions differs from obtained reconsolidation manipulation procedures utilizing restabilization retrieved (or reactivated) memories. case, blockade adrenergic beta-receptors during fearful stimulus might represent a promising intervention. substantial progress made in understanding interaction anxiety has potential enhance therapeutic success prevent relapse long run.

Language: Английский

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Neuroplasticity and Multilevel System of Connections Determine the Integrative Role of Nucleus Accumbens in the Brain Reward System

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(18), P. 9806 - 9806

Published: Sept. 10, 2021

A growing body of evidence suggests that nucleus accumbens (NAc) plays a significant role not only in the physiological processes associated with reward and satisfaction but also many diseases central nervous system. Summary current state knowledge on morphological functional basis such diverse function this structure may be good starting point for further basic clinical research. The NAc is part brain system (BRS) characterized by multilevel organization, extensive connections, several neurotransmitter systems. unique BRS result of: (1) hierarchical connections other areas, (2) well-developed plasticity regulating short- long-term synaptic potentiation signalling pathways, (3) cooperation among systems, (4) supportive neuroglia involved both pathological processes. Understanding complex possible combining results studies molecular, genetic, behavioral data. In review, we present views conditions, emphasizing its neuroplasticity processes,

Language: Английский

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