International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 2923 - 2934
Опубликована: Март 1, 2025
Background:
Periodontitis,
one
of
the
most
common
oral
diseases
caused
by
bacterial
infection
which
affects
gums,
periodontal
ligament
and
alveolar
bone,
is
a
leading
cause
tooth
loss
in
adults.
Current
clinical
treatments,
such
as
scaling
or
antibiotics,
often
result
incomplete
biofilm
removal
can
contribute
to
drug
resistance.
Methods:
To
address
these
limitations,
nanozyme
comprising
platinum,
copper,
selenium
was
developed,
then
incorporated
into
thermoresponsive
hydrogel.
Results:
When
applied
pockets
exposed
808
nm
laser
irradiation,
hydrogel
became
soft,
dissolving
release
nanozyme.
This
demonstrated
superoxide
dismutase
(SOD)-like
catalase
(CAT)-like
activity,
reducing
excess
reactive
oxygen
species
(ROS)
while
displaying
strong
antibacterial
anti-inflammatory
effects.
Conclusion:
photothermal
showed
excellent
biocompatibility
has
potential
overcome
challenges
current
periodontitis
treatments.
Keywords:
thermosensitive,
therapy,
hydrogel,
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 6012 - 6012
Опубликована: Май 30, 2024
In
exploring
the
challenges
of
bone
repair
and
regeneration,
this
review
evaluates
potential
tissue
engineering
(BTE)
as
a
viable
alternative
to
traditional
methods,
such
autografts
allografts.
Key
developments
in
biomaterials
scaffold
fabrication
techniques,
additive
manufacturing
cell
bioactive
molecule-laden
scaffolds,
are
discussed,
along
with
integration
bio-responsive
which
can
respond
physical
chemical
stimuli.
These
advancements
collectively
aim
mimic
natural
microenvironment
bone,
thereby
enhancing
osteogenesis
facilitating
formation
new
tissue.
Through
comprehensive
combination
vitro
vivo
studies,
we
scrutinize
biocompatibility,
osteoinductivity,
osteoconductivity
these
engineered
well
their
interactions
critical
cellular
players
healing
processes.
Findings
from
techniques
scaffolds
indicate
that
incorporating
nanostructured
materials
compounds
is
particularly
effective
promoting
recruitment
differentiation
osteoprogenitor
cells.
The
therapeutic
advanced
clinical
settings
widely
recognized
paper
advocates
continued
research
into
multi-responsive
systems.
Abstract
Sonodynamic
therapy
(SDT)
as
a
promising
non‐invasive
anti‐tumor
means
features
the
preferable
penetration
depth,
which
nevertheless,
usually
can't
work
without
sonosensitizers.
Sonosensitizers
produce
reactive
oxygen
species
(ROS)
in
presence
of
ultrasound
to
directly
kill
tumor
cells,
and
concurrently
activate
immunity
especially
after
integration
with
microenvironment
(TME)‐engineered
nanobiotechnologies
combined
therapy.
Current
sonosensitizers
are
classified
into
organic
inorganic
ones,
current
most
reviews
only
cover
highlighted
their
applications.
However,
there
have
few
specific
that
focus
on
including
design
principles,
regulation,
etc.
In
this
review,
first
according
rationales
rather
than
composition,
action
underlying
chemistry
highlighted.
Afterward,
what
how
TME
is
regulated
based
sonosensitizers‐based
SDT
nanoplatform
an
emphasis
targets‐engineered
elucidated.
Additionally,
applications
non‐cancer
diseases
also
outlined.
Finally,
setbacks
challenges,
proposed
potential
solutions
future
directions
pointed
out.
This
review
provides
comprehensive
detailed
horizon
sonosensitizers,
will
arouse
more
attentions
SDT.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 29, 2024
Abstract
Intra‐articular
injection
of
drugs
is
an
effective
strategy
for
osteoarthritis
(OA)
treatment.
However,
the
complex
microenvironment
and
limited
joint
space
result
in
rapid
clearance
drugs.
Herein,
a
nanogel‐based
proposed
prolonged
drug
delivery
remodeling.
Nanogel
constructed
through
functionalization
hyaluronic
acid
(HA)
by
amide
reaction
on
surface
Kartogenin
(KGN)‐loaded
zeolitic
imidazolate
framework‐8
(denoted
as
KZIF@HA).
Leveraging
inherent
hydrophilicity
HA,
KZIF@HA
spontaneously
forms
nanogels,
ensuring
extended
release
OA
microenvironment.
exhibits
sustained
over
one
month,
with
low
leakage
risk
from
cavity
compared
to
KZIF,
enhanced
cartilage
penetration,
reparative
effects
chondrocytes.
Notably,
KGN
released
serves
promote
extracellular
matrix
(ECM)
secretion
hyaline
regeneration.
Zn
2+
reverses
progression
promoting
M2
macrophage
polarization
establish
anti‐inflammatory
Ultimately,
facilitates
regeneration
alleviation
within
three
months.
Transcriptome
sequencing
validates
that
stimulates
macrophages
secretes
IL‐10
inhibit
JNK
ERK
pathways,
chondrocytes
recovery
enhancing
ECM
This
pioneering
nanogel
system
offers
new
therapeutic
opportunities
release,
presenting
significant
stride
treatment
strategies.
Abstract
Oral
mucositis
(OM)
is
the
most
common
and
refractory
complication
of
cancer
chemotherapy
radiotherapy,
severely
affecting
patients’
life
quality,
lowering
treatment
tolerance,
discouraging
patient
compliance.
Current
OM
delivery
systems
mostly
affect
comfort
use
lead
to
poor
compliance
unsatisfactory
effects.
Herein,
salivary
amylases
(SAs)‐responsive
buccal
tablets
consisting
porous
manganese‐substituted
Prussian
blue
(PMPB)
nanocubes
(NCs),
anti‐inflammatory
apremilast
(Apr)
starch
controller
have
been
engineered.
PMPB
NCs
with
large
surface
area
can
serve
as
carriers
load
Apr,
their
multienzyme‐mimicking
activity
enables
them
scavenge
reactive
oxygen
species
(ROS),
which
thus
synergize
Apr
mitigate
inflammation.
More
significantly,
respond
abundant
SAs
in
oral
cavity
realize
cascade,
continuous,
complete
drug
release
after
enzymatic
decomposition,
not
only
aids
high
tissue
affinity
prolong
resistance
time
but
also
improves
use.
The
preclinical
study
reveals
that
contributed
by
above
actions,
such
inflammation,
promote
endothelium
proliferation
migration,
accelerate
wound
healing
for
repressing
chemotherapy‐originated
intractable
positive
microenvironment
shorter
recovery
time,
holding
potentials
clinical
translation.
As
the
global
population
ages,
bone
diseases
have
become
increasingly
prevalent
in
clinical
settings.
These
conditions
often
involve
detrimental
factors
such
as
infection,
inflammation,
and
oxidative
stress
that
disrupt
homeostasis.
Addressing
these
disorders
requires
exogenous
strategies
to
regulate
osteogenic
microenvironment
(OME).
The
regulation
of
OME
can
be
divided
into
four
processes:
induction,
modulation,
protection,
support,
each
serving
a
specific
purpose.
To
this
end,
metal-organic
frameworks
(MOFs)
are
an
emerging
focus
nanomedicine,
which
show
tremendous
potential
due
their
superior
delivery
capability.
MOFs
play
numerous
roles
metal
ion
donors,
drug
carriers,
nanozymes,
photosensitizers,
been
extensively
explored
recent
studies.
This
review
presents
comprehensive
introduction
by
MOF-based
nanomaterials.
By
discussing
various
functional
MOF
composites,
work
aims
inspire
guide
creation
sophisticated
efficient
nanomaterials
for
disease
management.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(13)
Опубликована: Март 3, 2024
Abstract
Curcumin,
a
natural
bioactive
polyphenol
with
diverse
molecular
targets,
is
well
known
for
its
anti‐oxidation
and
anti‐inflammatory
potential.
However,
curcumin
exhibits
low
solubility
(<1
µg
mL
−1
),
poor
tissue‐targeting
ability,
rapid
oxidative
degradation,
resulting
in
bioavailability
stability
inflammatory
therapy.
Here,
poly(diselenide‐oxalate‐curcumin)
nanoparticle
(SeOC‐NP)
dual‐reactive
oxygen
species
(ROS)
sensitive
chemical
moieties
(diselenide
peroxalate
ester
bonds)
fabricated
by
one‐step
synthetic
strategy.
The
results
confirmed
that
dual‐ROS
endowed
SeOC‐NP
the
ability
of
targeted
delivery
significantly
suppress
degradation
high‐efficiency
In
detail,
amount
SeOC
about
4‐fold
lower
than
free
an
microenvironment.
As
result,
enhanced
antioxidant
activity
efficacy
vitro
analysis
scavenging
intracellular
ROS
suppressing
secretion
nitric
oxide
pro‐inflammatory
cytokines.
mouse
colitis
models,
orally
administered
can
remarkably
alleviate
symptoms
IBD
maintain
homeostasis
gut
microbiota.
This
work
provided
simple
effective
strategy
to
fabricate
ROS‐responsive
micellar
enhance
oxidation
medicine
precise
therapeutic
inflammation.
