Small Structures,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
The
clinical
treatment
of
central
nervous
system
(CNS)
injuries
presents
significant
challenges
due
to
the
inflammatory
microenvironment
(IME)
induced
by
CNS
injury,
which
inhibits
spontaneous
neuronal
regeneration.
Biomimetic
biomaterial‐based
IMEs
for
repair,
facilitate
reconstruction
neural
regeneration
circuits,
show
promise.
In
this
study,
development
novel
bioactive
peptide
nanofibers
(PNFs)/chitosan
(CS)/VD11
(VDELWPPWLPC)
hydrogels
(named
as
PCV)
is
reported,
created
reinforcing
composite
PNFs/CS
with
a
frog‐derived
neuroregenerative
(VD11).
exhibit
3D
porous
structure,
high
thermosensitivity,
good
injectability,
and
enhanced
neurotrophic
properties,
making
them
promising
candidates
repair.
in
vitro
tests
indicate
that
PCV
can
promote
proliferation,
migration,
differentiation
stem
cells
into
neurons,
well
guide
axonal
growth.
Additionally,
they
help
mitigate
responses
reducing
macrophage
activation
astrocyte
while
promoting
neovascularization.
vivo
animal
experimentsdemonstrate
enhance
blood
supply
damaged
area
migration
colonization
endogenous
support
Furthermore,
reduce
immune
limit
excessive
significantly
improving
motor
function
recovery
rats
spinal
cord
injuries.
these
findings,
it
suggested
provide
strategy
treating
regulating
IME.
Bioactive Materials,
Год журнала:
2024,
Номер
35, С. 534 - 548
Опубликована: Фев. 22, 2024
Rehabilitation
and
regenerative
medicine
are
two
promising
approaches
for
spinal
cord
injury
(SCI)
recovery,
but
their
combination
has
been
limited.
Conductive
biomaterials
could
bridge
scaffolds
with
electrical
stimulation
by
inducing
axon
regeneration
supporting
physiological
signal
transmission.
Here,
we
developed
aligned
conductive
hydrogel
fibers
incorporating
carbon
nanotubes
(CNTs)
into
methacrylate
acylated
gelatin
(GelMA)
via
rotating
liquid
bath
electrospinning.
The
electrospun
CNT/GelMA
mimicked
the
micro-scale
structure,
conductivity,
soft
mechanical
properties
of
neural
axons.
For
Biomaterials Science,
Год журнала:
2023,
Номер
12(1), С. 8 - 56
Опубликована: Окт. 25, 2023
Hydrogels
have
established
their
significance
as
prominent
biomaterials
within
the
realm
of
biomedical
research.
However,
injectable
hydrogels
garnered
greater
attention
compared
with
conventional
counterparts
due
to
excellent
minimally
invasive
nature
and
adaptive
behavior
post-injection.
With
rapid
advancement
emerging
chemistry
deepened
understanding
biological
processes,
contemporary
been
endowed
an
"intelligent"
capacity
respond
various
endogenous/exogenous
stimuli
(such
temperature,
pH,
light
magnetic
field).
This
innovation
has
spearheaded
revolutionary
transformations
across
fields
such
tissue
engineering
repair,
controlled
drug
delivery,
disease-responsive
therapies,
beyond.
In
this
review,
we
comprehensively
expound
upon
raw
materials
(including
natural
synthetic
materials)
principles
these
advanced
hydrogels,
concurrently
providing
a
detailed
discussion
prevalent
strategies
for
conferring
stimulus
responsiveness.
Finally,
elucidate
latest
applications
"smart"
stimuli-responsive
in
domain,
offering
insights
into
prospects.
Macromolecular Rapid Communications,
Год журнала:
2024,
Номер
45(11)
Опубликована: Фев. 24, 2024
Abstract
Hydrogels,
key
in
biomedical
research
for
their
hydrophilicity
and
versatility,
have
evolved
with
hydrogel
microspheres
(HMs)
of
micron‐scale
dimensions,
enhancing
role
minimally
invasive
therapeutic
delivery,
tissue
repair,
regeneration.
The
recent
emergence
nanomaterials
has
ushered
a
revolutionary
transformation
the
field,
which
demonstrates
tremendous
potential
targeted
therapies,
biological
imaging,
disease
diagnostics.
Consequently,
integration
advanced
nanotechnology
promises
to
trigger
new
revolution
realm
hydrogels.
HMs
loaded
combine
advantages
both
hydrogels
nanomaterials,
enables
multifaceted
functionalities
such
as
efficient
drug
sustained
release,
therapy,
lubrication,
biochemical
detection,
medical
biosensing
monitoring,
micro‐robotics.
Here,
this
review
comprehensively
expounds
upon
commonly
used
classifications.
Then,
it
provides
comprehensive
insights
into
raw
materials
preparation
methods
HMs.
Besides,
common
strategies
employed
achieve
nano‐micron
combinations
are
summarized,
latest
applications
these
combined
field
elucidated.
Finally,
valuable
future
design
development
provided.
Gels,
Год журнала:
2024,
Номер
10(3), С. 190 - 190
Опубликована: Март 9, 2024
The
repair
of
nervous
tissue
is
a
critical
research
field
in
engineering
because
the
degenerative
process
injured
system.
In
this
review,
we
summarize
progress
injectable
hydrogels
using
vitro
and
vivo
studies
for
regeneration
tissue.
Traditional
treatments
have
not
been
favorable
patients,
as
they
are
invasive
inefficient;
therefore,
promising
treatment
damaged
This
review
will
contribute
to
better
understanding
potential
scaffolds
drug
delivery
system
neural
applications.
Gels,
Год журнала:
2024,
Номер
10(5), С. 295 - 295
Опубликована: Апрель 25, 2024
Biomedicine
is
constantly
evolving
to
ensure
a
significant
and
positive
impact
on
healthcare,
which
has
resulted
in
innovative
distinct
requisites
such
as
hydrogels.
Chitosan-based
formulations
stand
out
for
their
versatile
utilization
drug
encapsulation,
transport,
controlled
release,
complemented
by
biocompatibility,
biodegradability,
non-immunogenic
nature.
Stimuli-responsive
hydrogels,
also
known
smart
have
strictly
regulated
release
patterns
since
they
respond
adapt
based
various
external
stimuli.
Moreover,
can
imitate
the
intrinsic
tissues’
mechanical,
biological,
physicochemical
properties.
These
characteristics
allow
stimuli-responsive
hydrogels
provide
cutting-edge,
effective,
safe
treatment.
Constant
progress
field
necessitates
an
up-to-date
summary
of
current
trends
breakthroughs
biomedical
application
chitosan-based
was
aim
this
review.
General
data
about
sensitive
ions,
pH,
redox
potential,
light,
electric
field,
temperature,
magnetic
are
recapitulated.
Additionally,
responsive
multiple
stimuli
mentioned.
Focusing
multifaceted
thoroughly
described.
The
vast
spectrum
encompasses
neurological
disorders,
tumors,
wound
healing,
dermal
infections.
Available
chitosan
strongly
support
idea
that
approaches
developing
novel
solutions
worth
improving.
present
paper
constitutes
valuable
resource
researchers
practitioners
currently
field.
Gels,
Год журнала:
2025,
Номер
11(2), С. 126 - 126
Опубликована: Фев. 9, 2025
Peripheral
nerve
injuries
pose
a
significant
clinical
challenge
due
to
the
complex
biological
processes
involved
in
repair
and
their
limited
regenerative
capacity.
Despite
advances
surgical
techniques,
conventional
treatments,
such
as
autografts,
are
faced
with
limitations
like
donor
site
morbidity
inconsistent
functional
outcomes.
As
such,
there
is
growing
interest
new,
novel,
innovative
strategies
enhance
regeneration.
Tissue
engineering/regenerative
medicine
its
use
of
biomaterials
an
emerging
example
strategy.
Within
realm
tissue
engineering,
functionalized
hydrogels
have
gained
considerable
attention
ability
mimic
extracellular
matrix,
support
cell
growth
differentiation,
even
deliver
bioactive
molecules
that
can
promote
repair.
These
be
engineered
incorporate
factors,
peptides,
stem
cells,
creating
conducive
microenvironment
for
cellular
axonal
Recent
advancements
materials
well
biology
led
development
sophisticated
hydrogel
systems,
not
only
provide
structural
support,
but
also
actively
modulate
inflammation,
recruitment,
stimulate
neurogenesis.
This
review
explores
potential
peripheral
repair,
highlighting
composition,
biofunctionalization,
mechanisms
action.
A
comprehensive
analysis
preclinical
studies
provides
insights
into
efficacy
these
promoting
growth,
neuronal
survival,
regeneration,
and,
ultimately,
recovery.
Thus,
this
aims
illuminate
promise
transformative
tool
field
bridging
gap
between
complexity
feasibility.
Deleted Journal,
Год журнала:
2023,
Номер
2(1), С. 288 - 306
Опубликована: Июль 26, 2023
Polysaccharides
are
inspiring
and
valuable
molecules
to
the
development
of
novel
drug
delivery
systems
owing
their
natural
availability,
non-toxicity,
biocompatibility,
good
biological
performance,
chemical
similarity
physiological
environment,
besides
noticeable
use
for
tailored-materials
assembly.
Biodegradable
hydrogels
based
on
polysaccharides
have
been
widely
studied
as
potential
pharmaceutical
forms
due
controlled
release
properties,
which
improve
bioavailability,
therapeutic
efficacy,
patient
compliance.
Despite
these
advantages,
polysaccharide
materials
present
insufficient
mechanical
properties
or
processability,
thus,
overcome
drawbacks,
feasible
suitable
crosslinking
methods
employed
strength
stability.
Therefore,
this
review
presents
recent
advances
in
hydrogels,
including
chitosan,
cellulose,
hyaluronic
acid,
alginate,
providing
examples
manufacturing
processes
with
emphasis
carriers
delivery.
Polysaccharide-based
represent
a
sustainable,
biocompatible,
appreciable
alternative
obtain
systems.
