Journal of Controlled Release, Год журнала: 2024, Номер 367, С. 637 - 648
Опубликована: Фев. 8, 2024
Язык: Английский
Acta Biomaterialia, Год журнала: 2023, Номер 159, С. 275 - 288
Опубликована: Янв. 26, 2023
Язык: Английский
Процитировано
48
Journal of Controlled Release, Год журнала: 2022, Номер 353, С. 391 - 410
Опубликована: Дек. 6, 2022
Язык: Английский
Процитировано
52
Regenerative Biomaterials, Год журнала: 2023, Номер 10
Опубликована: Янв. 1, 2023
Abstract Ferroptosis, a completely new form of regulated cell death, is mainly caused by an imbalance between oxidative damage and reductive protection has shown great anti-cancer potential. However, existing small-molecule ferroptosis inducers have various limitations, such as poor water solubility, drug resistance low targeting ability, hindering their clinical applications. Nanotechnology provides opportunities for ferroptosis-driven tumor therapy. Especially, stimuli-responsive nanomaterials stand out among others been widely researched because unique spatiotemporal control advantages. Therefore, it’s necessary to summarize the application those in ferroptosis. Here, we describe physiological feature illustrate current challenges induce cancer Then, that are classified elaborated according external internal stimuli. Finally, future perspectives field proposed. We hope this review facilitates paving way design intelligent nano-ferroptosis inducers.
Язык: Английский
Процитировано
42
Biomaterials Research, Год журнала: 2023, Номер 27(1)
Опубликована: Фев. 9, 2023
Self-assembled nanomedicine holds great potential in cancer theragnostic. The structures and dynamics of can be affected by a variety non-covalent interactions, so it is essential to ensure the self-assembly process at atomic level. Molecular (MD) simulation key technology link microcosm macroscale. Along with rapid development computational power methods, scientists could simulate specific intermolecular interactions. Thus, some experimental observations explained microscopic level synthesis would have traces follow. This review not only outlines concept, basic principle, parameter setting MD simulation, but also highlights recent progress for self-assembled nanomedicine. In addition, physicochemical parameters structure interaction between various assembled molecules under are discussed. Therefore, this will help advanced novice researchers quickly zoom on fundamental information gather thought-provoking ideas advance subfield
Язык: Английский
Процитировано
32
Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(8), С. 3252 - 3276
Опубликована: Март 5, 2023
Chemotherapy has occupied the critical position in cancer therapy, especially towards post-operative, advanced, recurrent, and metastatic tumors. Paclitaxel (PTX)-based formulations have been widely used clinical practice, while therapeutic effect is far from satisfied due to off-target toxicity drug resistance. The caseless multi-components make preparation technology complicated aggravate concerns with excipients-associated toxicity. self-assembled PTX nanoparticles possess a high content could incorporate various functional molecules for enhancing index. In this work, we summarize self-assembly strategy diverse nanodrugs of PTX. Then, advancement tumor emphasis on mono-chemotherapy, combinational theranostics, outlined. Finally, challenges potential improvements briefly spotlighted.
Язык: Английский
Процитировано
29
Nano Letters, Год журнала: 2023, Номер 23(4), С. 1530 - 1538
Опубликована: Янв. 31, 2023
Albumin has emerged as a versatile drug carrier. To harness albumin carrier for doxorubicin (DOX), we synthesized three acid-labile DOX prodrugs using stearic acid (SA), oleic (OA), and linoleic (LA) the albumin-binding motif, respectively. Different from conventional nanodrugs (such Abraxane, with loading of 10%), assembled nanoparticles (NPs) have an ultrahigh (>35%). Noteworthy, demonstrated that saturation fatty acids exerted great influence on colloidal stability prodrug NPs, thus affecting their in vivo pharmacokinetics, tumor accumulation antitumor efficacy. Furthermore, hydrazone bond-bridged could remain intact bloodstream but allow to be released acidic environment, resulting improved efficacy safety. Our work gives novel insights into structure-to-efficacy relationship albumin-bound provides simple strategy advanced nanomedicines.
Язык: Английский
Процитировано
26
Bioactive Materials, Год журнала: 2023, Номер 29, С. 50 - 71
Опубликована: Июнь 29, 2023
Cytoskeleton plays a significant role in the shape change, migration, movement, adhesion, cytokinesis, and phagocytosis of tumor cells. In clinical practice, some anti-cancer drugs achieve cytoskeletal therapeutic effects by acting on different protein components. However, absence cell-specific targeting, unnecessary recombination organisms would be disastrous, which also bring about severe side during anticancer process. Nanomedicine have been proven to superior small molecule cancer treatment due better stability lower effects. Therefore, this review summarized recent developments various nanomaterials disturbing cytoskeleton for enhanced therapeutics, including carbon, noble metals, metal oxides, black phosphorus, calcium, silicon, polymers, peptides, metal-organic frameworks, etc. A comprehensive analysis characteristics therapy as well future prospects challenges towards application were discussed. We aim drive emerging topic through refreshing perspectives based our own work what we learnt from others. This will help researchers quickly understand relevant information further advance development nanomedicine.
Язык: Английский
Процитировано
26
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Сен. 28, 2024
Язык: Английский
Процитировано
17
Cell Reports Medicine, Год журнала: 2024, Номер 5(3), С. 101432 - 101432
Опубликована: Фев. 21, 2024
Dimeric prodrug nanoassemblies (DPNAs) stand out as promising strategies for improving the efficiency and safety of chemotherapeutic drugs. The success trisulfide bonds (-SSS-) in DPNAs makes polysulfide a worthwhile focus. Here, we explore comprehensive role tetrasulfide (-SSSS-) constructing superior DPNAs. Compared to disulfide bonds, endow with superlative self-assembly stability, prolonged blood circulation, high tumor accumulation. Notably, ultra-high reduction responsivity make highly selective "tumor bomb" that can be ignited by endogenous reducing agents cells. Furthermore, present an "add fuel flames" strategy intensify reductive stress at sites replenishing exogenous agents, making considerable progress inhibition. This work elucidates crucial establishing intelligent DPNAs, alongside combination methodology, propelling new heights potent cancer therapy.
Язык: Английский
Процитировано
16
Aggregate, Год журнала: 2024, Номер 5(3)
Опубликована: Янв. 22, 2024
Abstract The induction of regulated cell death (RCD) through photo/ultrasound sensitization therapeutic agents has gained significant attention as a vital approach to combat drug resistance in tumors. Aggregation‐induced emission (AIE) generate reactive oxygen species activation, which can synergize with RCD inducers or directly induce RCD, ultimately resulting the tumor cells. presented comprehensive review delves into recent advancements AIE designed trigger inducers, encompassing apoptosis, necroptosis, pyroptosis, immunogenic death, autophagy, ferroptosis, and cuproptosis. Additionally, intricate regulatory mechanisms activatory‐AIE therapeutics influence distinct pathways are examined. A forward‐looking perspective on future developments pertinent challenges within this exciting realm is presented, anticipating continued evolution activatable transformative enhance therapy.
Язык: Английский
Процитировано
14