d-Galactose-induced accelerated aging model: an overview

Biogerontology, Год журнала: 2019, Номер 20(6), С. 763 - 782

Опубликована: Сен. 20, 2019

Язык: Английский

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Role of D-galactose-induced brain aging and its potential used for therapeutic interventions

Experimental Gerontology, Год журнала: 2017, Номер 101, С. 13 - 36

Опубликована: Ноя. 10, 2017

Язык: Английский

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The neuroprotective effects of caffeine in neurodegenerative diseases

CNS Neuroscience & Therapeutics, Год журнала: 2017, Номер 23(4), С. 272 - 290

Опубликована: Март 20, 2017

Caffeine is the most widely used psychostimulant in Western countries, with antioxidant, anti-inflammatory and anti-apoptotic properties. In Alzheimer's disease (AD), caffeine beneficial both men women, humans animals. Similar effects of were observed Parkinson's (PD); however, effect female PD patients controversial due to caffeine's competition estrogen for estrogen-metabolizing enzyme, CYP1A2. Studies conducted animal models amyotrophic lateral sclerosis (ALS) showed protective A

Язык: Английский

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Health Benefits and Chemical Composition of Matcha Green Tea: A Review

Molecules, Год журнала: 2020, Номер 26(1), С. 85 - 85

Опубликована: Дек. 27, 2020

Japanese matcha is a type of powdered green tea, grown in traditional way. Shading the plants during growth period enhances processes synthesis and accumulation biologically active compounds, including theanine, caffeine, chlorophyll various types catechins. Green tea contains four main catechins, i.e., (-)-epicatechin (EC), (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC) (-)-epigallocatechin-3-gallate (EGCG), which latter most abundant their best condensed source. Due to its unique chemical composition prized flavour, sets it apart from other beverages, considered highest quality tea. Its health-promoting properties are attributed high content antioxidant anti-inflammatory substances. Studies confirming potential beverages claim that originates considerable phenolic compound with beneficial effects on human health. for preventing many diseases supporting cognitive function, regular consumption may have positive effect both physical mental The aim this review was compile health benefits It first such be undertaken, presents bioactive compounds systematic manner.

Язык: Английский

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Natural Compounds for Alzheimer’s Disease Therapy: A Systematic Review of Preclinical and Clinical Studies

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(9), С. 2313 - 2313

Опубликована: Май 10, 2019

Alzheimer’s Disease (AD) is a neurodegenerative disorder related with the increase of age and it main cause dementia in world. AD affects cognitive functions, such as memory, an intensity that leads to several functional losses. The continuous incidence demands for urgent development effective therapeutic strategies. Despite extensive research on this disease, only few drugs able delay progression disease are currently available. In last years, compounds pharmacological activities isolated from plants, animals microorganisms, revealed have beneficial effects treatment AD, targeting different pathological mechanisms. Thus, wide range natural may play relevant role prevention proven be efficient preclinical clinical studies. This work aims review until date were described having significant benefits neurological focusing studies present trials.

Язык: Английский

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Neuroprotective Effects of Coffee Bioactive Compounds: A Review

International Journal of Molecular Sciences, Год журнала: 2020, Номер 22(1), С. 107 - 107

Опубликована: Дек. 24, 2020

Coffee is one of the most widely consumed beverages worldwide. It usually identified as a stimulant because high content caffeine. However, caffeine not only coffee bioactive component. The beverage in fact mixture number compounds such polyphenols, especially chlorogenic acids (in green beans) and caffeic acid roasted beans), alkaloids (caffeine trigonelline), diterpenes (cafestol kahweol). Extensive research shows that consumption appears to have beneficial effects on human health. Regular intake may protect from many chronic disorders, including cardiovascular disease, type 2 diabetes, obesity, some types cancer. Importantly, seems be also correlated with decreased risk developing neurodegenerative conditions Alzheimer’s Parkinson’s dementia. reduce stroke. mechanism underlying these is, however, still poorly understood. This review summarizes current knowledge neuroprotective potential main components, i.e., caffeine, acid, trigonelline, kahweol, cafestol. Data both vitro vivo preclinical experiments, their therapeutic applications, are reviewed discussed. Epidemiological studies clinical reports this matter described. Moreover, molecular mechanism(s) by which components provide neuroprotection reviewed.

Язык: Английский

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Caffeine effects on systemic metabolism, oxidative-inflammatory pathways, and exercise performance

Nutrition Research, Год журнала: 2020, Номер 80, С. 1 - 17

Опубликована: Май 16, 2020

Caffeine, a xanthine alkaloid compound, is consumed widely and daily by humans, as it present in several regular beverages such tea, coffee, soda beverages, some drugs. Its consumption triggers arousal alertness, improves mood, causes the release of catecholamines, which induce beneficial effects on human behavior. Nonetheless, caffeine has been related to other antioxidant anti-inflammatory actions that are extremely important health, altering cellular redox inflammatory status dose-dependent manner. Caffeine intake also shown ergogenic effects, attributed different factors, enhanced substrate utilization, fatigue delay, alertness. As such, athletes from sports modalities, with positive negative declared. Although peripheral tissues heart, skeletal muscle, adipocytes impacted, there deficit recognized mechanisms systemic metabolism when compared action central nervous system. This review summarizes most relevant classical current literature available regarding use metabolic situations, oxidative status, well anaerobic aerobic physical exercises. Here, we identified non-central system modulation, still unknown or controversial, highlighting its influence essential crucial impacts human's organism adaptation.

Язык: Английский

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Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice

Journal of Neuroinflammation, Год журнала: 2019, Номер 16(1)

Опубликована: Ноя. 20, 2019

It is widely accepted that mitochondria have a direct impact on neuronal function and survival. Oxidative stress caused by mitochondrial abnormalities play an important role in the pathophysiology of lipopolysaccharide (LPS)-induced memory impairment. Elamipretide (SS-31) novel mitochondrion-targeted antioxidant. However, elamipretide cognitive sequelae inflammatory oxidative unknown.We utilized MWM contextual fear conditioning test to assess hippocampus-related learning performance. Molecular biology techniques ELISA were used examine function, stress, response. TUNEL Golgi-staining was detect neural cell apoptosis density dendritic spines mouse hippocampus.Mice treated with LPS exhibited dysfunction, response, apoptosis, loss hippocampus, leading impaired performance test. Treatment significantly ameliorated LPS-induced impairment during behavioral tests. Notably, not only provided protective effects against dysfunction but also facilitated regulation brain-derived neurotrophic factor (BDNF) signaling, including reversal synaptic-signaling proteins increased synaptic structural complexity.These findings indicate can be attenuated antioxidant elamipretide. Consequently, may therapeutic potential preventing damage from neuroinflammation contribute perioperative neurocognitive disorders (PND), which makes target for treatment strategies PND.

Язык: Английский

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Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway

Food and Chemical Toxicology, Год журнала: 2017, Номер 109, С. 505 - 516

Опубликована: Сен. 30, 2017

Язык: Английский

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Polydatin attenuatesd-galactose-induced liver and brain damage through its anti-oxidative, anti-inflammatory and anti-apoptotic effects in mice

Food & Function, Год журнала: 2016, Номер 7(11), С. 4545 - 4555

Опубликована: Янв. 1, 2016

Accumulating evidence has shown that chronic injection of d-galactose (d-gal) can mimic natural aging, with accompanying liver and brain injury. Oxidative stress apoptosis play a vital role in the aging process. In this study, antioxidant ability polydatin (PD) was investigated using four established vitro systems. An vivo study also conducted to investigate possible protective effect PD on d-gal-induced damage. The results showed had remarkable free radical scavenging activity 2,2-diphenyl-1-picryl-hydrazyl (DPPH˙), 2,2'-azino-bis(3-ethylbenzo-thiazoline-6-sulfonic acid) (ABTS+˙) ions, hydroxyl superoxide anions. Results indicated that, group treated d-gal plus PD, remarkably decreased depression body weight organ indexes, reduced levels serum alanine aminotransferase (ALT) aspartate (AST), alleviated alterations histopathology. significantly level MDA elevated SOD, GSH-Px, CAT T-AOC brain. addition, inflammatory mediators, such as TNF-α, IL-1β IL-6 were markedly after treatment. Western blotting revealed treatment noticeably attenuated elevation Bcl-2/Bax ratio caspase-3 protein expression Overall, our findings indicate could effectively attenuate damage, mechanism might be associated decreasing oxidative stress, inflammation caused by d-gal. holds good potential for further development into promising pharmaceutical candidate age-associated diseases.

Язык: Английский

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