Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 155709 - 155709
Опубликована: Сен. 1, 2024
Язык: Английский
Pharmacological Research, Год журнала: 2024, Номер 203, С. 107150 - 107150
Опубликована: Март 21, 2024
Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global morbidity, disability, mortality, highlighting the necessity for transformative treatment approaches. Photodynamic therapy (PDT) has aroused continuous interest as viable alternative conventional cancer treatments that encounter drug resistance. Nanotechnology brought new advances in medicine shown great potential delivery treatment. For precise efficient therapeutic utilization of such tumor approach high spatiotemporal selectivity minimal invasiveness, carrier-free noncovalent nanoparticles (NPs) based on chemo-photodynamic combination essential. Utilizing natural products foundation nanodrug development offers unparalleled advantages, including exceptional pharmacological activity, easy functionalization/modification, well biocompatibility. The natural-product-based, carrier-free, NPs revealed excellent synergistic anticancer activity comparison free photosensitizers bioactive products, representing an favorable avenue improve efficacy. Herein, comprehensive summary current strategies representative application examples past decade (such paclitaxel, 10-hydroxycamptothecin, doxorubicin, etoposide, combretastatin A4, epigallocatechin gallate, curcumin) therapy. We highlight insightful design synthesis smart aim enhance PDT Meanwhile, we discuss future challenges opportunities associated these provide enlightenment, spur innovative ideas, facilitate PDT-mediated clinical transformation.
Язык: Английский
Процитировано
15
Nano-Micro Letters, Год журнала: 2024, Номер 16(1)
Опубликована: Май 14, 2024
The flourishing progress in nanotechnology offers boundless opportunities for agriculture, particularly the realm of nanopesticides research and development. However, concerns have been raised regarding human environmental safety issues stemming from unrestrained use non-therapeutic nanomaterials nanopesticides. It is also important to consider whether current development strategy based on nanocarriers can strike a balance between investment return, if complex material composition genuinely improves efficiency, safety, circularity Herein, we introduced concept with minimizing carriers (NMC) prepared through prodrug design molecular self-assembly emerging as practical tools address limitations, compared it employing (NNC). We further summarized NMC examined potential challenges its preparation, performance, production. Overall, asserted that systems serve innovative driving force catalyzing green efficient revolution nanopesticides, offering way out predicament.
Язык: Английский
Процитировано
15
Coordination Chemistry Reviews, Год журнала: 2024, Номер 508, С. 215774 - 215774
Опубликована: Март 18, 2024
Язык: Английский
Процитировано
13
ACS Nano, Год журнала: 2024, Номер 18(35), С. 23827 - 23841
Опубликована: Авг. 20, 2024
Carrier-free nanodrugs with extraordinary active pharmaceutical ingredient (API) loading (even 100%), avoidable carrier-induced toxicity, and simple synthetic procedures are considered as one of the most promising candidates for disease theranostics. Substantial studies commercial success "carrier-free" nanocrystals have demonstrated their strong clinical potential. However, practical translations remain challenging impeded by unpredictable assembly processes, insufficient delivery efficiency, an unclear in vivo fate. In this Perspective, we systematically outline contemporary emerging carrier-free based on diverse APIs, well highlight opportunities challenges translation. Looking ahead, further improvements design preparation, drug delivery, efficacy, safety nanomedicines essential to facilitate translation from bench bedside.
Язык: Английский
Процитировано
8
Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 68 - 68
Опубликована: Янв. 6, 2025
Nanoparticle-based drug delivery systems hold great promise for improving the effectiveness of anti-tumor therapies. However, their clinical translation remains hindered by several significant challenges, including intricate preparation processes, limited loading capacity, and concerns regarding potential toxicity. In this context, pure drug-assembled nanosystems (PDANSs) have emerged as a promising alternative, attracting extensive research interest due to simple methods, high efficiency, suitability large-scale industrial production. This innovative approach presents new opportunities enhance both safety therapeutic efficacy cancer treatments. review comprehensively explores recent progress in application PDANSs therapy. It begins detailing self-assembly mechanisms fundamental principles underlying PDANS formation. The discussion then advances strategies assembling single nanoparticles, well co-assembly multiple drugs. Subsequently, addresses combination treatment modalities, encompassing diagnostic applications. These include combinations chemotherapeutic agents, phototherapeutic approaches, integration chemotherapy with phototherapy, synergistic use immunotherapy other methods. Finally, highlights advancing tumor therapy prospects application, providing key insights future aimed at optimizing technology broadening its utility treatment.
Язык: Английский
Процитировано
1
Nanoscale, Год журнала: 2023, Номер 15(44), С. 17658 - 17697
Опубликована: Янв. 1, 2023
Camptothecin (CPT) is a cytotoxic alkaloid that attenuates the replication of cancer cells via blocking DNA topoisomerase 1.
Язык: Английский
Процитировано
19
Advanced Materials, Год журнала: 2024, Номер 36(30)
Опубликована: Май 1, 2024
Abstract The in vivo fate of chemotherapeutic drugs plays a vital role understanding the therapeutic outcome, side effects, and mechanism. However, lack imaging abilities drugs, tedious labeling processes, premature leakage agents result loss fidelity between signals. Herein, an amphiphilic polymer is created by copolymerization near‐infrared‐II (NIR‐II) fluorophore tracer (T) anticancer Pt(IV) prodrug (D) cisplatin hand‐holding manner into one chain for first time. obtained Polyplatin DT capable delivering fluorophores concomitantly at precise D/T ratio, thereby resulting tracking platinum even readout them real‐time via NIR‐II imaging. can self‐assemble nanoparticles, referred to as Nanoplatin . Furthermore, caspase‐3 cleavable peptide that serves apoptosis reporter attached , DTR are simultaneously evaluating efficacy. Overall, it reported here design theranostic with drug tracers, efficacy reporters work concert provide insight mechanism action.
Язык: Английский
Процитировано
8
Advanced Functional Materials, Год журнала: 2024, Номер 34(37)
Опубликована: Май 15, 2024
Abstract Carrier‐free nanodrugs that integrate chemodrugs and other therapeutic agents demonstrate good efficacy minimized side effects, showing promise for combined therapy. However, a key challenge lies in enhancing the bioavailability potential of through controllable assembly process. Herein, carrier‐free photothermal nanodrug (ZPQ NPs) is constructed flavonol‐driven with amine‐substituted perylene diimide enhanced chemo‐photothermal cancer The flavonol, particularly quercetin, facilitates J‐aggregation derivatives within contributes to multiple improvements, including red‐shifted absorption, fluorescence intensity, improved conversion efficiency as well excellent photostability. Moreover, also demonstrates cellular uptake intracellular reactive oxygen species scavenging capability. combination quercetin effect effectively kills cells, alleviates inflammation following Guided by vivo imaging, application ZPQ NPs results complete tumor elimination inhibits recurrence This work presents straightforward strategy constructing exhibit simultaneous enhancements both photophysical properties biological activity.
Язык: Английский
Процитировано
8
Journal of Colloid and Interface Science, Год журнала: 2024, Номер 677, С. 523 - 540
Опубликована: Авг. 14, 2024
Язык: Английский
Процитировано
7
Nanoscale, Год журнала: 2024, Номер 16(9), С. 4392 - 4406
Опубликована: Янв. 1, 2024
This review summarizes the amplification effect of SNAs in various combined therapy treatment strategies and highlights recent advances clinical translation.
Язык: Английский
Процитировано
6