Decoding the role of miRNAs in oral cancer pathogenesis: A focus on signaling pathways

Pathology - Research and Practice, Год журнала: 2023, Номер 252, С. 154949 - 154949

Опубликована: Ноя. 18, 2023

Язык: Английский

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The emerging role of miRNAs in myocardial infarction: From molecular signatures to therapeutic targets

Pathology - Research and Practice, Год журнала: 2024, Номер 253, С. 155087 - 155087

Опубликована: Янв. 1, 2024

Язык: Английский

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Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Parkinson’s disease

Pathology - Research and Practice, Год журнала: 2023, Номер 253, С. 155023 - 155023

Опубликована: Дек. 10, 2023

Язык: Английский

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The potential relevance of long non-coding RNAs in colorectal cancer pathogenesis and treatment: A review focus on signaling pathways

Pathology - Research and Practice, Год журнала: 2023, Номер 253, С. 155044 - 155044

Опубликована: Дек. 20, 2023

Язык: Английский

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Role of Non-Coding RNAs in Diagnosis, Prediction and Prognosis of Multiple Myeloma

Cancers, Год журнала: 2024, Номер 16(5), С. 1033 - 1033

Опубликована: Март 2, 2024

Multiple myeloma (MM) is the second most common hematologic malignancy in world and accounts for 15% of primary hemocytopathies, with an ever-increasing number new cases. It asymptomatic 30% instances; hence, determination highly sensitive specific markers necessary to make a proper diagnosis. In last 20 years, miRNAs, involved regulating expression genes responsible cell proliferation differentiation, including tumor cells, have been identified as potential diagnostic prognostic markers. The main aim following review was outline role miRNAs diagnosis prognosis MM, considering their pathogenesis disease identifying target pathways. For this purpose, publications dating from 2013–2023 reviewed. Based on available data, it concluded that non-coding RNAs could be MM. Furthermore, they may serve therapeutic targets certain drugs.

Язык: Английский

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Unraveling the role of miRNAs in the diagnosis, progression, and drug resistance of oral cancer

Pathology - Research and Practice, Год журнала: 2023, Номер 253, С. 155027 - 155027

Опубликована: Дек. 11, 2023

Язык: Английский

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MicroRNAs and proteolytic cleavage of receptors in cancers: A comprehensive review of regulatory interactions and therapeutic implications

Heliyon, Год журнала: 2024, Номер 10(7), С. e28167 - e28167

Опубликована: Март 21, 2024

Cancer remains a challenging disease worldwide, necessitating innovative approaches to better comprehend its underlying molecular mechanisms and devise effective therapeutic strategies. Over the past decade, microRNAs (miRNAs) have emerged as crucial players in cancer progression due their regulatory roles various cellular processes. Moreover, involvement of unwanted soluble receptors has gained increasing attention because they contribute tumorigenesis or drug resistance by disrupting normal signaling pathways neutralizing ligands. This comprehensive review explores intricate interplay between miRNAs unwanted-soluble context biology. study provides an analysis interactions these receptors, elucidating how can either suppress enhance expression. MiRNAs directly target receptor transcripts, thereby regulating levels. They also modulate proteolytic cleavage membrane-bound into forms targeting sheddases, such ADAMs MMPs. Furthermore, delves potential manipulating receptors. Various strategies, including synthetic miRNA mimics anti-miRNAs, hold promise for restoring inhibiting function counteract aberrant activity. exploring miRNA-based delivery systems may provide targeted precise therapies that minimizing off-target effects. In conclusion, this sheds light on networks involving biology uncovering novel targets, paving way developing anti-cancer therapies.

Язык: Английский

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The emerging role of miRNAs in pituitary adenomas: From molecular signatures to diagnostic potential

Experimental Cell Research, Год журнала: 2024, Номер 442(2), С. 114279 - 114279

Опубликована: Окт. 1, 2024

Язык: Английский

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Harnessing the power of miRNAs: The molecular architects of asthma pathogenesis and potential targets for therapeutic innovation

Pathology - Research and Practice, Год журнала: 2023, Номер 253, С. 155054 - 155054

Опубликована: Дек. 22, 2023

Язык: Английский

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Unveiling the regulatory role of miRNAs in stroke pathophysiology and diagnosis

Pathology - Research and Practice, Год журнала: 2024, Номер 253, С. 155085 - 155085

Опубликована: Янв. 1, 2024

Язык: Английский

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