Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Alzheimer’s disease

Pathology - Research and Practice, Год журнала: 2023, Номер 253, С. 155007 - 155007

Опубликована: Дек. 4, 2023

Язык: Английский

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The role of miRNAs in multiple sclerosis pathogenesis, diagnosis, and therapeutic resistance

Pathology - Research and Practice, Год журнала: 2023, Номер 251, С. 154880 - 154880

Опубликована: Окт. 11, 2023

Язык: Английский

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miRNAs as modulators of neuroinflammation and excitotoxicity: Implications for stroke therapeutics

Pathology - Research and Practice, Год журнала: 2024, Номер 253, С. 155093 - 155093

Опубликована: Янв. 1, 2024

Язык: Английский

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Deciphering signaling pathway interplay via miRNAs in malignant pleural mesothelioma

Pathology - Research and Practice, Год журнала: 2023, Номер 252, С. 154947 - 154947

Опубликована: Ноя. 13, 2023

Язык: Английский

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From strings to signals: Unraveling the impact of miRNAs on diagnosis, and progression of colorectal cancer

Pathology - Research and Practice, Год журнала: 2023, Номер 251, С. 154857 - 154857

Опубликована: Окт. 4, 2023

Язык: Английский

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Investigating the regulatory role of miRNAs as silent conductors in the management of pathogenesis and therapeutic resistance of pancreatic cancer

Pathology - Research and Practice, Год журнала: 2023, Номер 251, С. 154855 - 154855

Опубликована: Окт. 5, 2023

Язык: Английский

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Possible role of miRNAs in pheochromocytoma pathology - Signaling pathways interaction

Pathology - Research and Practice, Год журнала: 2023, Номер 251, С. 154856 - 154856

Опубликована: Окт. 5, 2023

Язык: Английский

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Decoding the role of miRNAs in oral cancer pathogenesis: A focus on signaling pathways

Pathology - Research and Practice, Год журнала: 2023, Номер 252, С. 154949 - 154949

Опубликована: Ноя. 18, 2023

Язык: Английский

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The emerging role of miRNAs in myocardial infarction: From molecular signatures to therapeutic targets

Pathology - Research and Practice, Год журнала: 2024, Номер 253, С. 155087 - 155087

Опубликована: Янв. 1, 2024

Язык: Английский

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Editorial: Asbestos and disease genomics: is mesothelioma a genomic paradigm?

Frontiers in Toxicology, Год журнала: 2025, Номер 6

Опубликована: Янв. 3, 2025

engineered materials as a result of advances in (nano)technological developments manufactured fibers (Nel, 2023).• Discovery asbestos-related diseases Asbestos mining on an industrial scale started from the end 1800's with development mesothelioma exposed miners first reported 50 years later (Wagner et al., 1960). The use asbestos had been regulated many countries since 1995, however several developed and developing continue to mine, export high volumes (Frank, 2020) approximately 1,200,000 metric tons used worldwide 2021 (USGS 2022 https://pubs.usgs.gov/publication/mcs2022). Over time, risk exposure identified at workplace has extended asbestos-containing material, during efforts remove existing structures (Gottesfeld, 2024). Secondary scenarios have become increasing cause for concern buildings constructed mid-twentieth century are reaching end-oflife will require significant repair, reconstruction or demolition near future. These emerging threats potential increase more diverse populations disease (Alpert (Singh Frank, 2023) (Metintas 2024).Our historical experience left us heavy burden disease. Lessons, however, learnt relevant both scientific context, including increased understanding mechanism underpinning fiber toxicity, ethical perspective. Recognition long latency period initial lack compensatory mechanisms within body neutralize pathogenic fibers, highlights need address humanitarian on-going anticipate health risks before new procedures utilizing EMP design novel fiber-like materials.• remarkable characteristics related toxicity Experimental studies revealed that morphology physico-chemical properties modulate biological effects emphasizing role dimensions, especially length (Stanton 1981). Additionally, vitro acellular systems were quantify dissolution rate confirm durability biopersistence fibers. Epidemiological substantiated these findings, relevance dimensions. From this research it can be summarized size, chemistry surface reactivity basic parameters govern toxicity. They involved responses such uptake phagocytosis, interactions molecules, genetic alterations, inflammation, immunity, translocation processes (Sayan Mossman, 2015) (Nagai Toyokuni, 2010) (Donaldson (Kuroda, 2021) (Huang 2011). Further added toxicological rigidity. This information develop models predict potency hazard based dimensions (Wylie Korchevskiy, or, further refinement, "fiber toxicity/pathogenicity index (FPTI)" which includes 18 associated adverse effect pathological process (Gualtieri, 2018) .The FPP is now being applied assess carcinogenic fibrous particles glass refractory carbon nanotubes (CNTs), metallic (high aspect ratio nanomaterials, HARNs) (Murphy (Kane 2018).The legacy continuing into studying EMPs HARNs avoid damage.Experimental demonstrated inhaled towards pleural space although not fully understood (Miserocchi 2008). retention cavity seems partly size stomata pores through fluid drains lymphatic system (from 0.8µm mice 10µm human) (Schinwald 2012). Subsequent accumulation leads direct irritation mesothelial layer, frustrated phagocytosis macrophages inflammation. Direct instillation CNTs other nanomaterials (HARN) similar pathogenicity action terms production oxidative stress, inflammation genotoxicity 2013) (Yoshida, 2019) 2010).The cell response was studied culture models, SV40-immortalized, non-tumorigenic human line. Normal cells internalize chrysotile found phagolysosomes, lysosome degranulation Inflammatory factors shown released by may propagate chronic inflammatory environment vivo subjecting stress eventually transformation 2015). In Research Topic, Leinardi al provide comprehensive review components after death contribute context silica exposure. While induce release pro-inflammatory damage molecular patterns HMGB1 (Leinardi 2022), carcinogenesis promoted directly (Suarez 2023).To examine early changes along mesothelium transcriptomic kinetic analysis injection C57BL/6 carried out timepoints between one week up 20 months (Chernova 2017). Samples consisted straight CNTs, short (carcinogenic) (lower pathogenicity) amosite lesions 1 6 samples expression genes, whereas gene controls clustered together. pathways activation kinases pro-oncogenic dysregulation maintained tumor development. status Cdkn2a (encoding two proteins p16 Ink4a p19 ARF ) ortholog key suppressor genes (TSGs) CDKN2A P16 INK4a P14 examined 1-year post tumors induced CNT authors silencing (Ink4a/Arf) hypermethylation co-deletion fiber-induced tumors, also acquired p19/Arf deletion. shows epigenetic present inflammatory, pre-tumoral stage emphasizes similarities (PM) 2017).Transcriptome analyses asbestos-induced inflamed tissue investigated heterozygous Nƒ2 +/-C57Bl6 intraperitoneally crocidolite 12 weeks assessed 33 last (Rehrauer 2018). decreased level Yap/Taz localized nucleus mesothelium, indicating deregulation Hippo pathway Although conducted genetically modified mouse model susceptibility, study due Nf2 mutation plays progression mesothelioma. loss regularly reviewed article Sekido Sato part Topic (Sekido Sato, 2023), NF2 appears late event, genomic but environment.• Histopathology characterization PM continuously evolving fields biology, histological classification, genetic, chromosomal status, state regulatory pathways, interactions, immunological microenvironment.The recent classification retains three main histologic subtypes: epithelioid, biphasic sarcomatoid, epithelioid sarcomatoid elements. Mesothelioma subtypes show variety architectures, cellular aspects stroma, their prognosis different, worse survival subtype compared (Sauter 2022) (Husain There no epidemiological evidence association given type (Vorster (Franklin 2016). However, conditional model, where mostly spontaneously Nf2, p53 cells, accelerates onset (Farahmand 2023). One notable feature recruitment observed precursor raises possibility microenvironment events downstream provides cues favoring proliferation when absence asbestos. supported observation different methylation levels CpG sites detected reflective intra-tumor heterogeneity subtype. DNA preferentially located islands sub-type, while mainly non-CPG areas histology suggesting histo-molecular gradients linked regulation (Blum 2019).While there limited showing short-term currently large data biomolecular PM. usually biopsied time beginning exposure, possibly decades.Investigations landscape go back 2,000s methodologies large-scale analytical methods highthroughput data. modifications using multi-omic approaches next-generation sequencing microarrays. As histology, heterogeneous tumor, rather low number somatic mutations cancers, types rearrangements, copy alteration, genome duplication most them TSGs (CDKN2A, BAP1, NF2, SETD2, LATS2, TP53) TERT promoter (Bueno 2016) (Meiller 2021)(Febres-Aldana 2024) (Creaney (Nair (Mangiante At lower rate, SWI/SNF family (ARID1A, ARID2, SMARCA4), histone (KMT2D, SETD2) mutually exclusive (Quetel (Febres-Aldana 2024).Transcriptomic heterogenous profiles could allowing refined subgroups characterized alterations distinguish phenotype patients' better outcome profile than 2019). Investigation showed reality individual patients composed combination epithelioid-like sarcomatoid-like (defined E/S score) (Alcala enrichment BAP1 SETD2 highest E.score, TERT_prom, TP53 S-score, LATS2 frequently altered nonepithelioid positively S-score 2019).A predisposition suggested families cases incidence syndrome multifunctional (BRCA1-associated protein, BAP-1 gene) discovered (Testa Other proportion frequency germline variants repair (Panou (Belcaid 2023).Additional influence pathogenesis experimental Cross Collaborative MexTAg 72 background tested resulting identification predictive (Fisher 2024).Knowing induces chromosome damage, missgegregation mammalian performed detect signature Recently, clinical profiling near-haploidization aggressive occurred younger without (Yang SR, Losses chromosomes 14q few studies, example recurrent 14q11.2-q21 asbestos-exposed exposed, losses similarly lost murine (Björkqvist 1999) (Jean oxidation animals, ROS-induced Recently reinvestigated statistical analysis, variability (SVA), considers across (Morrison difference single base substitutions unexposed patients, within-sample diversity less across-sample those SVA generate footprint Interestingly, biopsies taken distinct anatomical (Zhang 2021). study, NGS variants, event.A meta-analysis 53 total 97 microRNAs (miRNA) analyzed (Vandenhoeck frequent mesotheliomas aberrantly methylated bodies count lung, majority significantly hypermethylated comparison normal CDH1, ESR1, miR-34b/c, PGR, RARb, SFRP1, WIF1, one, APC hypomethylated. A cycle control-associated genes: CDKN2A, CDKN2B, RASSF1, CCND2, HPPBP1 control confounding (Christensen counts 2009).Dysregulation miRNA non coding RNAs (LncRNAs) (Abd-Elmawla (Xu Many miRNAs targeted epithelial mesenchymal markers dependent score LncRNA NEAT1, PCT6, HOTAIR, GAS5 biomarkers.RNA editing according untranslated regions (UTR) transcripts introns . Results Escore RNA 3'UTR, S-score. Then, vary EMT, consistent EMT +/-mice RNA-editing signature, mediated adenosine-deaminase-acting-on dsRNA (ADAR), tissues, higher RNAediting 2018).Research aims identifying immune goal reactivate defense. Single-cell enriched foetal-like endothelial CXCL9/10/11+ cytotoxic, exhausted T lymphocytes (Giotti B, al, 2024), line bulk-RNA Detailed permit immunotherapy susceptibility killing.Research concerning major etiological factor its multifactorial action. specificities fiber-cell interaction (phagocytosis) damages. cancer involves mutations, PM, damages significant. unfrequent among whole population, largely populations, likely polymorphism induction. persistent act (ROS production, pre-malignant immunosuppression), elicit neoplastic modify microenvironment. E S remarkable, tumoral/EMT evolution posing challenge effective therapeutic intervention.While genomics provided footprints link established asbestos, imprints poorly identified. Investigations pleura apoptosis, permitted impacts 2011) 2017) Studies confirmed importance under asbestosexposure (reviewed (Blanquart Berns, 2020)). altered, alteration event 2023)) application technologies reveal driving alteration.Presently, we propose double paradigm, toxicologic researches EMPs, some specific changes. Nevertheless, progress made cells.

Язык: Английский

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