The reproductive and transgenerational toxicity of microplastics and nanoplastics: A threat to mammalian fertility in both sexes DOI
Yuchong He,

Ruocheng Yin

Journal of Applied Toxicology, Год журнала: 2023, Номер 44(1), С. 66 - 85

Опубликована: Июнь 29, 2023

Abstract Microplastics (MPs) and nanoplastics (NPs) are extensively distributed in the environment. However, a comprehensive review in‐depth discussion on effects of MPs NPs to reproductive capacity transgenerational toxicity mammals, especially humans, is lacked. It suggested that microplastics could accumulate mammalian organs exert toxic system for both sexes. For males, damage consists abnormal testicular sperm structure, decreased vitality, endocrine disruption, which were caused by oxidative stress, inflammation, apoptosis cells, autophagy, cytoskeleton, hypothalamic‐pituitary‐testicular axis. females, includes ovary uterus structure granulosa cell apoptosis, hypothalamic‐pituitary‐ovary axis abnormalities, tissue fibrosis. toxicity, premature mortality existed rodent offspring after maternal exposure microplastics. Among surviving offspring, metabolic disorders, dysfunction, immune, neurodevelopmental, cognitive disorders detected, these events directly correlated with translocation NPs. Studies human‐derived cells or organoids demonstrated studies sexes yet phase exploring suitable experimental models, more detailed research threat human fertility still urgently needed. Further will help assess public health risks.

Язык: Английский

Polystyrene-microplastics and DEHP co-exposure induced DNA damage, cell cycle arrest and necroptosis of ovarian granulosa cells in mice by promoting ROS production DOI
Hao Wu,

Qiaohan Liu,

Naixi Yang

и другие.

The Science of The Total Environment, Год журнала: 2023, Номер 871, С. 161962 - 161962

Опубликована: Фев. 10, 2023

Язык: Английский

Процитировано

115
‘Plasticosis’: Characterising macro- and microplastic-associated fibrosis in seabird tissues DOI Creative Commons

Hayley S. Charlton-Howard,

Alexander L. Bond, Jack Rivers‐Auty

и другие.

Journal of Hazardous Materials, Год журнала: 2023, Номер 450, С. 131090 - 131090

Опубликована: Фев. 26, 2023

As biota are increasingly exposed to plastic pollution, there is a need closely examine the sub-lethal 'hidden' impacts of ingestion. This emerging field study has been limited model species in controlled laboratory settings, with little data available for wild, free-living organisms. Highly impacted by ingestion, Flesh-footed Shearwaters (Ardenna carneipes) thus an apt these environmentally relevant manner. A Masson's Trichrome stain was used document any evidence plastic-induced fibrosis, using collagen as marker scar tissue formation proventriculus (stomach) 30 Shearwater fledglings from Lord Howe Island, Australia. Plastic presence highly associated widespread and extensive changes to, even loss of, structure within mucosa submucosa. Additionally, despite naturally occurring indigestible items, such pumice, also being found gastrointestinal tract, this did not cause similar scarring. highlights unique pathological properties plastics raises concerns other Further, extent severity fibrosis documented gives support novel, fibrotic disease, which we define 'Plasticosis,'.

Язык: Английский

Процитировано

108
Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-κB/NLRP3 pathway DOI

Yujiao He,

Zhe Li,

Tong Xu

и другие.

Chemosphere, Год журнала: 2022, Номер 307, С. 135662 - 135662

Опубликована: Июль 10, 2022

Язык: Английский

Процитировано

101
4-tert-butylphenol triggers common carp hepatocytes ferroptosis via oxidative stress, iron overload, SLC7A11/GSH/GPX4 axis, and ATF4/HSPA5/GPX4 axis DOI Creative Commons
Jiawen Cui, Qin Zhou,

Meijin Yu

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2022, Номер 242, С. 113944 - 113944

Опубликована: Авг. 1, 2022

4-tert-butylphenol (4-tBP) is a toxic environmental pollutant with moderate bioaccumulation, persistence, and long-term toxicity. Its toxicity to aquatic organisms has become an issue of concern. However, the molecular mechanism 4-tBP remained unclear. Liver target organ for pollutants. Here, we established 4-tBP-exposed model in vivo primary hepatocyte vitro common carp (Cyprinus carpio L.). We found increased hepatic-somatic index (HSI) abnormal serum biochemical indexes (ALT, AST, LDH) after exposure, indicating liver damage. further revealed that damaged structural integrity livers typical features ferroptosis. Based on toxicogenomics analysis, ferroptosis likely be involved 4-tBP-induced Moreover, our experiment provided evidences 4-tBP-exposure led excess oxidative stress, iron overload, decreased MMP, expression ferroptosis-related factors. Interestingly, ferrostatin-1 (Fer-1, inhibitor) pretreatment alleviated above changes. In summary, demonstrated triggered hepatocytes via SLC7A11/GSH/GPX4 axis, ATF4/HSPA5/GPX4 axis. For first time, discovered Fer-1 can ameliorate 4-tBP, which needs more investigations. Our results scientific basis fish poisoning.

Язык: Английский

Процитировано

75
Recent progress of microplastic toxicity on human exposure base on in vitro and in vivo studies DOI

Zhengguo Liu,

Xue‐yi You

The Science of The Total Environment, Год журнала: 2023, Номер 903, С. 166766 - 166766

Опубликована: Сен. 2, 2023

Язык: Английский

Процитировано

69
Human Microplastics Exposure and Potential Health Risks to Target Organs by Different Routes: A Review DOI
Ziye Yang,

Meixue Wang,

Zhihong Feng

и другие.

Current Pollution Reports, Год журнала: 2023, Номер 9(3), С. 468 - 485

Опубликована: Авг. 17, 2023

Язык: Английский

Процитировано

59
BPA and low-Se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the PTEN/PI3K/AKT/mTOR pathway DOI Creative Commons
Wenying Sun, Yutian Lei,

Zhihui Jiang

и другие.

Journal of Advanced Research, Год журнала: 2024, Номер unknown

Опубликована: Фев. 1, 2024

Bisphenol A (BPA) is a widespread environmental pollutant which has serious toxic effects on organisms. One of the crucial trace elements selenium (Se), whose shortage can harm biological tissues and enhance toxicity contaminants, in apoptosis autophagy are core events. An vivo model was established to investigate BPA low-Se chicken pancreatic tissue, identify possible potential molecular mechanism. total 80 1-day-old broiler chickens (Xinghua Chicken Farm, Harbin, China) were stochastically divided into 4 groups (n=20/group): Control group, + group. Pancreatic tissue collected at day 42 detect changes markers. First, data showed that exposure gave rose structural abnormalities oxidative stress, mitochondrial dysfunction homeostasis imbalance, mitophagy. In addition, co-exposure caused most damage tissue. terms mechanism, it found mitophagy induced by related activation PTEN/PI3K/AKT/mTOR pathway. summary, study exacerbated mitochondria damage, regulating

Язык: Английский

Процитировано

59
Polystyrene microplastics induced inflammation with activating the TLR2 signal by excessive accumulation of ROS in hepatopancreas of carp (Cyprinus carpio) DOI Creative Commons
Jie Cui,

Yanhe Zhang,

Lin Liu

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 251, С. 114539 - 114539

Опубликована: Янв. 12, 2023

Polystyrene microplastics (PS-MPs) affect the immune defense function on carp (Cyprinus carpio). The PS-MPs model of was established by feeding with particle size 8 µm and concentration 1000 ng/L water. Hepatopancreas test revealed activities AKP, ALT, AST LDH abnormal increase. induced tissue damage lead to hepatopancreas function. also a oxidative stress antioxidant enzymes SOD, CAT, GSH-PX, T-AOC decreasing reactive oxygen species (ROS) excessive accumulation. activated Toll like receptor-2 (TLR2) signaling pathway. mRNA protein expressions TLR2, Myeloid differentiation primary response 88 (MyD88), tumor necrosis factor receptor-associated 6 (TRAF6), NF-κB p65, Tumor (TNF-α), Interleukin-1β (IL-1β), Inducible Nitric Oxide Synthase (iNOS), cycooxygenase 2(COX2) increased in both hepatocytes qPCR Western blotting analysis mode. ELISA showed TNF-α, IL-1β, iNOS, COX2 inflammatory molecule were hepatocytes. results that caused serious injure brought effects carp. present study displayed harm freshwater fish, provided some suggestions references for toxicological studies environment.

Язык: Английский

Процитировано

56
Polystyrene microplastics disrupt female reproductive health and fertility via sirt1 modulation in zebrafish (Danio rerio) DOI
Priya Gupta, Archisman Mahapatra,

Anjali Suman

и другие.

Journal of Hazardous Materials, Год журнала: 2023, Номер 460, С. 132359 - 132359

Опубликована: Авг. 22, 2023

Язык: Английский

Процитировано

48
Microplastics exposure: implications for human fertility, pregnancy and child health DOI Creative Commons

Rewa E. Zurub,

Yusmaris Cariaco, Michael G. Wade

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 14

Опубликована: Янв. 4, 2024

Plastics found in our everyday environment are becoming an increasing concern for individual and population-level health, the extent of exposure potential toxic effects these contaminants on numerous human organ systems clear. Microplastics (MPs), tiny plastic particles, appear to have many same biological as their precursors compounded effect accumulation different organs. Recently, microplastic was observed placenta, raising important questions related health pregnancies offspring. These concerns particularly heightened considering developmental origins disease (DOHaD) framework, which postulates that utero can programme lifelong The current review examines state knowledge this topic highlights avenues future investigation.

Язык: Английский

Процитировано

36