Uptake and Biotransformation of the Tire Rubber-derived Contaminants 6-PPD and 6-PPD Quinone in the Zebrafish Embryo (Danio rerio)

Environmental Science & Technology, Год журнала: 2023, Номер 57(41), С. 15598 - 15607

Опубликована: Окт. 2, 2023

N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6-PPD) is a widely used antioxidant in tire rubber known to enter the aquatic environment via road runoff. The associated transformation product (TP) 6-PPD quinone (6-PPDQ) causes extreme acute toxicity some fish species (e.g., coho salmon). To interpret species-specific toxicity, information about biotransformation products of 6-PPDQ would be relevant. This study investigated toxicokinetics and zebrafish embryo (ZFE) model. Over 96 h exposure, accumulated ZFE with concentration factors ranging from 140 2500 for 70 220 6-PPDQ. A total 22 TPs 12 were tentatively identified using liquid chromatography coupled high-resolution mass spectrometry. After exposure 6-PPD, comprised 47% peak area (TPA), 4-hydroxydiphenylamine being most prominent ZFE. Upon >95% taken up was biotransformed, + O glucuronide dominating (>80% TPA). Among other reactive N-phenyl-p-benzoquinone imine found. knowledge this may support studies organisms.

Язык: Английский

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Widespread occurrence of two typical N, N’-substituted p-phenylenediamines and their quinones in humans: Association with oxidative stress and liver damage

Journal of Hazardous Materials, Год журнала: 2024, Номер 468, С. 133835 - 133835

Опубликована: Фев. 19, 2024

Язык: Английский

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Environmental profiles, hazard identification, and toxicological hallmarks of emerging tire rubber-related contaminants 6PPD and 6PPD-quinone

Environment International, Год журнала: 2024, Номер 187, С. 108677 - 108677

Опубликована: Апрель 21, 2024

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) is commonly used in rubber compounds as antioxidants to protect against degradation from heat, oxygen, and ozone exposure. This practice extends the lifespan of products, including tires, by preventing cracking, aging, deterioration. However, environmental consequences waste generated during product use, particularly formation 6PPD-quinone (6PPD-Q) through reaction 6PPD with ozone, have raised significant concerns due their detrimental effects on ecosystems. Extensive research has revealed widespread occurrence its derivate 6PPD-Q various compartments, air, water, soil. The emerging substance been shown pose acute mortality long-term hazards aquatic terrestrial organisms at concentrations below environmentally relevant levels. Studies demonstrated toxic a range organisms, zebrafish, nematodes, mammals. These include neurobehavioral changes, reproductive dysfunction, digestive damage exposure pathways. Mechanistic insights suggest that mitochondrial stress, DNA adduct formation, disruption lipid metabolism contribute toxicity induced 6PPD-Q. Recent findings human samples, such blood, urine, cerebrospinal fluid, underscore importance further public health toxicological implications these compounds. distribution, fate, biological effects, underlying mechanisms environment highlight urgent need for additional understand address impacts

Язык: Английский

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Polyphenolic Nanoparticle-Modified Probiotics for Microenvironment Remodeling and Targeted Therapy of Inflammatory Bowel Disease

ACS Nano, Год журнала: 2024, Номер 18(20), С. 12917 - 12932

Опубликована: Май 9, 2024

Inflammatory bowel diseases (IBDs) refer to multifaceted disorders in the intestinal microenvironment and microbiota homeostasis. In view of broad bioactivity high compatibility polyphenols, there is considerable interest developing a polyphenol-based collaborative platform remodel IBD regulate microbiota. Here, we demonstrated coordination assembly nanostructured polyphenols modify probiotics simultaneously deliver drugs for treatment. Inspired by distinctive structure tannic acid (TA), fabricated pBDT-TA using self-polymerizable aromatic dithiol (BDT) TA, which exhibited excellent antioxidant anti-inflammatory capability vitro. We thus coated sodium alginate (SA) surface Escherichia coli Nissle 1917 layer construct EcN@SA-pBDT-TA. The modified showed improved resistance oxidative inflammatory stress, resulted superior colon accumulation retention model mice. Further, EcN@SA-pBDT-TA could alleviate dextran sulfate (DSS)-induced colitis controlling response, repairing barriers, modulating gut Importantly, EcN@SA-pBDT-TA-mediated drug delivery achieve an therapeutic effect DSS Given availability functionality polyphenol prebiotics, expected that polyphenol-modified provided solution develop

Язык: Английский

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Co-exposure to polystyrene microplastics and cypermethrin enhanced the effects on hepatic phospholipid metabolism and gut microbes in adult zebrafish

Journal of Hazardous Materials, Год журнала: 2023, Номер 465, С. 133051 - 133051

Опубликована: Ноя. 23, 2023

Язык: Английский

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Responses of soil and collembolan (Folsomia candida) gut microbiomes to 6PPD-Q pollution

The Science of The Total Environment, Год журнала: 2023, Номер 900, С. 165810 - 165810

Опубликована: Июль 25, 2023

Язык: Английский

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6PPD induced cardiac dysfunction in zebrafish associated with mitochondrial damage and inhibition of autophagy processes

Journal of Hazardous Materials, Год журнала: 2024, Номер 471, С. 134357 - 134357

Опубликована: Апрель 21, 2024

Язык: Английский

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Environmentally Relevant Concentrations of S-6PPD-Quinone Caused More Serious Hepatotoxicity Than R-Enantiomer and Racemate in Oncorhynchus mykiss

Environmental Science & Technology, Год журнала: 2024, Номер 58(40), С. 17617 - 17628

Опубликована: Сен. 23, 2024

6PPD-quinone (6PPD-Q) is frequently detected in various environmental media, and the environmentally relevant concentrations can be fatal to

Язык: Английский

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Tire-derived contaminants 6PPD and 6PPD-Q: Analysis, sample handling, and reconnaissance of United States stream exposures

Chemosphere, Год журнала: 2024, Номер 363, С. 142830 - 142830

Опубликована: Июль 11, 2024

The environmental ubiquity of tire and road wear particles (TRWP) underscores the need to understand occurrence, persistence, effects tire-related chemicals in aquatic ecosystems. One such chemical is 6PPD-quinone (6PPD-Q), a transformation product antioxidant 6PPD. In urban stormwater runoff 6PPD-Q can exceed acute toxicity thresholds for several salmonid species being implicated significant coho salmon losses Pacific Northwest. There critical prevalence across watersheds identify habitats heavily affected by TRWPs. We conducted reconnaissance 6PPD surface waters United States from sites (N = 94) with varying land use (urban, agricultural, forested) streamflow better stream exposures. A rapid, low-volume direct-inject, liquid chromatography mass spectrometry method was developed quantitation screening Laboratory holding times, bottle material, headspace, filter materials were investigated inform best practices sampling analysis. Glass bottles PTFE-lined caps minimized sorption borosilicate glass fiber filters provided highest recovery. stable at least 5 months pure laboratory solutions 75 days °C minimal headspace water stormwaters. Results also indicated samples be frozen extend times. not detected any 526 analyzed there no detections agricultural or forested sites. frequently (57%, N 90) impacted (45%, 276) concentrations ranging 0.002 0.29 μg/L. concentrations, above lethal level salmon, occurred during events. This highlights importance capturing episodic events areas near ecologically relevant habitat nursery grounds sensitive species.

Язык: Английский

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The occurrence of typical psychotropic drugs in the aquatic environments and their potential toxicity to aquatic organisms - A review

The Science of The Total Environment, Год журнала: 2023, Номер 900, С. 165732 - 165732

Опубликована: Июль 24, 2023

Язык: Английский

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