Comparative Biochemistry and Physiology Part D Genomics and Proteomics, Год журнала: 2024, Номер 53, С. 101370 - 101370
Опубликована: Ноя. 28, 2024
Язык: Английский
ACS Nano, Год журнала: 2024, Номер 18(4), С. 3733 - 3751
Опубликована: Янв. 22, 2024
Nanoplastics (NPs), as emerging pollutants, have attracted global attention. Nevertheless, the adverse effects of NPs on female reproductive health, especially unexplained miscarriage, are poorly understood. Defects trophoblast cell migration and invasion associated with miscarriage. Migrasomes were identified cellular organelles largely unidentified functions. Whether might affect migration, invasion, migrasome formation induce miscarriage has been completely unexplored. In this study, we selected polystyrene nanoplastics (PS-NPs, 50 nm) a model plastic particles treated human cells pregnant mice PS-NPs at doses near actual environmental exposure in humans. We found that to induced mouse suppressed ROCK1-mediated migration/invasion formation. SOX2 was transcription factor ROCK1. activated autophagy promoted degradation SOX2, thus suppressing SOX2-mediated ROCK1 transcription. Supplementing murine or could efficiently rescue alleviate Analysis protein levels ROCK1, TSPAN4, NDST1, P62, LC-3BII/I PS-NP-exposed cells, villous tissues patients, placental gave consistent results. Collectively, study revealed toxicity their potential regulatory mechanism, indicating NP is risk for health.
Язык: Английский
Процитировано
41
Environmental Pollution, Год журнала: 2024, Номер 350, С. 123972 - 123972
Опубликована: Апрель 18, 2024
Язык: Английский
Процитировано
19
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
Although considered an "eco-friendly" biodegradable plastic, polylactic acid (PLA) microplastic (PLA-MP) poses a growing concern for human health, yet its effects on male reproductive function remain underexplored. This study investigated the toxicity of PLA in mice and potential mechanisms. To this end, our vivo vitro experiments demonstrated that after degradation digestive system, significant number PLA-MP-derived nanoparticles could penetrate blood–testis barrier (BTB) localize within spermatogenic microenvironment. Mice exposed to PLA-MPs long time exhibited toxicity, evidenced by decreased sperm concentration motility, increased deformity rates, disrupted sex hormone levels. Further analysis revealed impaired BTB, induced mitochondrial dysfunction testes, triggered oxidative stress through excessive ROS production from mitochondria, leading further testicular damage. Notably, nanoplastics internalized sheath structure sperm, causing dose-dependent impairments function. Transcriptome analyses indicated spermatogenesis inhibiting expression key mRNA involved process. Collectively, findings highlight toxic effect damaging BTB impairing function, which provides insights into toxicological implications microplastics mammalian fertility.
Язык: Английский
Процитировано
3
The Science of The Total Environment, Год журнала: 2024, Номер 919, С. 170592 - 170592
Опубликована: Фев. 12, 2024
The expanded uses of bioplastics require understanding the potential health risks associated with their exposure. To address this issue, Drosophila melanogaster as a versatile terrestrial in vivo model was employed, and polylactic acid nanoplastics (PLA-NPLs), proxy for bioplastics, were tested material model. Effects determined larvae exposed 4 days to different concentrations (25, 100, 400 μg/mL) 463.9 ± 129.4 nm PLA-NPLs. Transmission electron microscopy (TEM) scanning microscope (SEM) approaches permitted detection PLA-NPLs midgut lumen larvae, interacting symbiotic bacteria. Enzymatic vacuoles observed carriers, collecting enabling crossing peritrophic membrane, finally internalizing into enterocytes. Although no toxic effects egg-to-adult survival, cell uptake causes cytological disturbances formation large vacuoles. translocation across intestinal barrier demonstrated by presence hemolymph. PLA-NPL exposure triggered damage, oxidative stress, DNA inflammation responses, evaluated via wide set marker genes. Collectively, these structural molecular interferences caused generated high levels stress damage hemocytes larvae. point out need further studies aiming deepen before adopting safe plastic alternative.
Язык: Английский
Процитировано
17
TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 178, С. 117832 - 117832
Опубликована: Июнь 22, 2024
Язык: Английский
Процитировано
16
Toxics, Год журнала: 2024, Номер 12(3), С. 178 - 178
Опубликована: Фев. 26, 2024
The escalating prevalence of microplastics and nanoplastics in aquatic environments is a major challenge affecting the behavior reproductive health organisms while posing potential risks to human ecosystems. This review focuses on neurobehavioral changes toxicity MNPs zebrafish their relationships. At same time, caused by were studied, synergistic effects interaction these pollutants with other environmental contaminants explored. In addition, zebrafish, as model organism, provide valuable insights into subtle but important behavior, which critical for understanding success, suggesting that behavioral can serve an early biomarker toxicity. based classical endocrine disruptor models research methods, current status was reviewed, further indicated parameters be used effective rapid tool evaluate MNPs. However, methods rapidly assessing are still area exploration. To address limitations challenges scope research, this outlines future directions aim improving our impacts work aims inform targeted policies advance public strategies growing pollution.
Язык: Английский
Процитировано
14
Fish & Shellfish Immunology, Год журнала: 2024, Номер 150, С. 109619 - 109619
Опубликована: Май 10, 2024
Язык: Английский
Процитировано
14
The Science of The Total Environment, Год журнала: 2024, Номер 948, С. 175000 - 175000
Опубликована: Июль 23, 2024
Язык: Английский
Процитировано
13
The Science of The Total Environment, Год журнала: 2024, Номер 946, С. 174386 - 174386
Опубликована: Июль 1, 2024
Язык: Английский
Процитировано
9
Environmental Science & Technology, Год журнала: 2025, Номер unknown
Опубликована: Март 21, 2025
Biodegradable plastics (BPs) are promoted as eco-friendly alternatives to conventional plastics. However, compared microplastics (MPs), they degrade rapidly into biodegradable (BMPs), which may lead a more significant accumulation of BMPs in the environment. This review systematically compares and MPs, summarizes current knowledge on their environmental behaviors impacts ecosystems human health, offers recommendations for future research. detected water, sediments, indoor dust, food, marine organisms, samples. Compared prone transformations, such photodegradation biodegradation, results shorter migration distance across different matrices. Like can adsorb pollutants transport them enhancing toxicity health risks through Trojan horse effect. Studies indicate that negatively impact terrestrial aquatic than MPs by disrupting nutrient cycling inhibiting plant animal growth. In vivo vitro research also shows BMP degradation products increase bioavailability, exacerbating neurotoxicity overall toxicity. findings BMPs' effects remain inconsistent. Further evaluation trade-offs between biodegradability is needed address these uncertainties.
Язык: Английский
Процитировано
1