Sensors and Actuators B Chemical, Год журнала: 2023, Номер 382, С. 133539 - 133539
Опубликована: Фев. 16, 2023
Язык: Английский
Nano Letters, Год журнала: 2024, Номер 24(9), С. 2912 - 2920
Опубликована: Фев. 23, 2024
Nanozymes with peroxidase-like activity have been extensively studied for colorimetric biosensing. However, their catalytic and specificity still lag far behind those of natural enzymes, which significantly affects the accuracy sensitivity To address this issue, we design PdSn nanozymes selectively enhanced activity, improves a immunoassay. The is higher than that Pd nanozymes. Theoretical calculations reveal p–d orbital hybridization Sn not only results in an upward shift d-band center to enhance hydrogen peroxide (H2O2) adsorption but also regulates O–O bonding strength H2O2 achieve selective activation. Ultimately, nanozyme-linked immunosorbent assay has successfully developed sensitively accurately detect prostate-specific antigen (PSA), achieving low detection limit 1.696 pg mL–1. This work demonstrates promising approach detecting PSA clinical diagnosis.
Язык: Английский
Процитировано
22
Carbon, Год журнала: 2024, Номер 219, С. 118831 - 118831
Опубликована: Янв. 17, 2024
Язык: Английский
Процитировано
21
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Авг. 13, 2024
Abstract As nanoscale materials with the function of catalyzing substrates through enzymatic kinetics, nanozymes are regarded as potential alternatives to natural enzymes. Compared protein‐based enzymes, exhibit attractive characteristics low preparation cost, robust activity, flexible performance adjustment, and versatile functionalization. These advantages endow them wide use from biochemical sensing environmental remediation medical theranostics. Especially in biomedical diagnosis, feature catalytic signal amplification provided by makes emerging labels for detection biomarkers diseases, rapid developments observed recent years. To provide a comprehensive overview progress made this dynamic field, here an diagnosis enabled is provided. This review first summarizes synthesis nanozyme then discusses main strategies applied enhance their activity specificity. Subsequently, representative utilization combined biological elements disease reviewed, including related metabolic, cardiovascular, nervous, digestive diseases well cancers. Finally, some development trends nanozyme‐enabled highlighted, corresponding challenges also pointed out, aiming inspire future efforts further advance promising field.
Язык: Английский
Процитировано
19
Deleted Journal, Год журнала: 2024, Номер 2(2)
Опубликована: Март 4, 2024
Abstract As emerging alternatives to natural enzymes, nanoscale materials featuring enzyme‐like catalytic behaviors (nanozymes) exhibit some attractive merits including robust activity, low cost, and easy‐to‐regulate performance. These have enabled them be intensively used in the biomedical field recent years. To remedy lack of selectivity most nanozymes, deoxyribonucleic acid (DNA) chains with specific recognition functions are utilized integrate nanozymes produce various nanozyme–DNA combinations via adsorption/desorption. In formed combinations, DNA component provides molecular/ionic role, nanozyme part offers response catalytically amplified signals, enabling detect analytes biomarkers selectively sensitively. highlight this interesting topic, here we made a critical review interactions between their applications biosensing disease diagnosis. First, strategies for conjugation onto surface were introduced briefly. Then, summarized detail, where flexible modulations activity by adsorption/desorption as well factors analyzed, potential impacts caused on characteristics pointed out. After that, typical DNA‐mediated modulation toxic ion sensing, health risk factor monitoring, diagnosis introduced. end, prospects combination presented, future challenges also discussed, attract more interest effort advance promising area.
Язык: Английский
Процитировано
18
Chemical Engineering Journal, Год журнала: 2024, Номер 485, С. 150058 - 150058
Опубликована: Фев. 28, 2024
Язык: Английский
Процитировано
17
Microchemical Journal, Год журнала: 2025, Номер unknown, С. 112810 - 112810
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
3
ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(18), С. 21750 - 21757
Опубликована: Апрель 28, 2022
Nanomaterials with enzyme-like characteristics (called nanozymes) show their extreme potentials as alternatives to natural enzymes. Covalent organic frameworks (COFs) metal-free nanozymes have attracted huge attention for catalytic applications due flexible molecular design and synthetic strategies conjugated, porous, chemically stable architectures. Designing high-performance two-dimensional (2D) porous COF materials embedded functional building units modulating nanozymes' activity is of immense importance in contemporary research. The proper combination donor-acceptor (D-A) fragments within a skeleton an effective strategy decrease the band gap provide strong charge-transfer pathway highly charge separation. Herein, two heteroporous COFs using electron-deficient 4,4'-(thiazolo[5,4-d]thiazole-2,5-diyl)dibenzaldehyde (Tz) unit or 4,4'-(benzo[c][1,2,5]thiadiazole-4,7-diyl)dibenzaldehyde (Td) electron-rich tetrakis(4-aminophenyl)ethane (ETTA) linkers were presented. resulting crystalline showed outstanding oxidase-like under light irradiation, which can catalyze oxidation typical substrates corresponding evolution color absorption. light-activatable ETTA-Tz prominent serve colorimetric probe quantitative detection sulfide ions linear range 1-50 μM limit 0.27 3 min. approach could also be used ion human serum samples. research demonstrated future potential D-A motifs fully conjugated obtain excellent mimic enzyme activity.
Язык: Английский
Процитировано
49
Biosensors, Год журнала: 2022, Номер 12(4), С. 251 - 251
Опубликована: Апрель 16, 2022
Given the superiorities in catalytic stability, production cost and performance tunability over natural bio-enzymes, artificial nanomaterials featuring enzyme-like characteristics (nanozymes) have drawn extensive attention from academic community past decade. With these merits, they are intensively tested for sensing, biomedicine environmental engineering. Especially analytical sensing field, enzyme mimics found wide use biochemical detection, monitoring food analysis. More fascinatingly, rational design enables one fabrication of materials with versatile activities, which show great promise further advancement nanozyme-involved field. To understand progress such an exciting here we offer a review nanozymes multiple activities their application prospects. The main types enzyme-mimetic first introduced, followed by summary current strategies that can be employed to multi-activity nanozymes. In particular, typical at least two reviewed. Finally, opportunities applied field discussed, potential challenges also presented, better guide development methods sensors using different features.
Язык: Английский
Процитировано
45
ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(22), С. 25042 - 25049
Опубликована: Май 31, 2022
Bacterial infection is still a thorny problem threatening human health, and nanozymes offer promising alternative strategy to combat the health threat posed by bacterial infection. However, antibacterial efficacies of are unsatisfactory because low catalytic activity their inability trap bacteria. Herein, multifunctional nanozyme, polydopamine (PDA)-modified copper oxide (CuxO-PDA) designed overcome this challenge. CuxO-PDA showed peroxidase-mimicking was enhanced upon near-infrared (NIR) irradiation. negatively charged under neutral or alkaline condition no obvious activity. On contrary, surface charge can be switched positive acidic conditions, which target More interestingly, well-dispersed aggregate rapidly NIR irradiation, trapped bacteria together. It found that shortening distance between nanozyme could improve effect. The obtained cause DNA degradation, lipid peroxidation, biofilm eradication. good effect against two kinds representative bacteria, Escherichia coli (Gram-negative) Staphylococcus aureus (Gram-positive). experiment in vivo further proved favorable nanozyme.
Язык: Английский
Процитировано
43
ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(20), С. 24736 - 24746
Опубликована: Май 10, 2023
As a typical antibiotic pollutant, tetracycline (TC) is producing increasing threats to the ecosystem and human health, exploring convenient means for monitoring of TC needed. Here, we proposed alkali-etched imprinted Mn-based Prussian blue analogues featuring superior oxidase-mimetic activity precise recognition colorimetric sensing TC. Simply etching (Mn-PBAs) with NaOH could expose sites surfaces significantly improve their catalytic activity. Density functional theory calculations were employed screen molecularly polymer (MIP) layer target identification. Consequently, designed Mn-PBANaOH@MIP possessed rich channels substrates get in touch active Mn-PBANaOH core, showing an excellent capacity trigger chromogenic oxidation 3,3',5,5'-tetramethylbenzidine (TMB) without use H2O2. If was introduced, it would be recognized selectively by MIP shell masked TMB access, resulting obstruction reaction. According this mechanism, selective optical detection achieved, performance stability, reusability, reliability as well practicability also verified, promising potential complex matrices. Our work not only presents effective way enhance enzyme-like but provides facile approach sensing. Additionally, will inspire exploration nanozymes various applications.
Язык: Английский
Процитировано
34