Nutrition Metabolism and Cardiovascular Diseases, Год журнала: 2023, Номер 34(1), С. 177 - 187
Опубликована: Сен. 21, 2023
Язык: Английский
Current Issues in Molecular Biology, Год журнала: 2023, Номер 45(8), С. 6651 - 6666
Опубликована: Авг. 12, 2023
Oxidative stress is a critical factor in the pathogenesis and progression of diabetes its associated complications. The imbalance between reactive oxygen species (ROS) production body’s antioxidant defence mechanisms leads to cellular damage dysfunction. In diabetes, chronic hyperglycaemia mitochondrial dysfunction contribute increased ROS production, further exacerbating oxidative stress. This burden adversely affects various aspects including impaired beta-cell function insulin resistance, leading disrupted glucose regulation. Additionally, stress-induced blood vessels endothelial development diabetic vascular complications such as retinopathy, nephropathy, cardiovascular diseases. Moreover, organs tissues throughout body, kidneys, nerves, eyes, are vulnerable stress, resulting neuropathy, retinopathy. Strategies mitigate include therapy, lifestyle modifications, effective management hyperglycaemia. However, research necessary comprehensively understand underlying evaluate efficacy interventions preventing treating By addressing it might be possible alleviate improve patient outcomes.
Язык: Английский
Процитировано
198
The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2023, Номер 108(7), С. 1824 - 1834
Опубликована: Янв. 26, 2023
Abstract Context It remains controversial whether the choice of daily eating window early or later in time-restricted (TRE) intervention (early TRE) has different effects on weight loss and metabolic health. Objective A network meta-analysis was performed to evaluate efficacy between TRE adults with obesity overweight. Methods We searched PubMed, Embase, Web Science, Cochrane Library for randomized controlled trials (RCTs) published until October 16, 2022. conducted a body parameters, including glycemic metabolism, blood pressure, lipid profiles. Results Twelve RCTs 730 obese overweight were included this meta-analysis. Early both elicited moderate reductions insulin resistance (IR) (homeostasis model assessment IR) when compared non-TRE. Interestingly, showed more effectiveness than improving IR vs TRE: −0.44; 95% CI, −0.86 −0.02; P < .05), whereas no statistically significant difference detected −0.31 kg; −1.15 0.53 >.05). In addition, rather benefits metabolism pressure No differences observed fasting glucose, Conclusion This suggests that people may choose effective management benefits. Nevertheless, further large-scale are warranted verify our findings.
Язык: Английский
Процитировано
41
Nature Medicine, Год журнала: 2025, Номер unknown
Опубликована: Янв. 7, 2025
Язык: Английский
Процитировано
2
Diabetes & Metabolic Syndrome Clinical Research & Reviews, Год журнала: 2024, Номер 18(2), С. 102952 - 102952
Опубликована: Фев. 1, 2024
Язык: Английский
Процитировано
8
Current Obesity Reports, Год журнала: 2025, Номер 14(1)
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
1
EBioMedicine, Год журнала: 2023, Номер 93, С. 104680 - 104680
Опубликована: Июнь 24, 2023
Язык: Английский
Процитировано
20
Obesity, Год журнала: 2023, Номер 31(6), С. 1463 - 1485
Опубликована: Май 19, 2023
Abstract Objective This systematic scoping review aimed to map and synthesize research on feasibility of time‐restricted eating (TRE) in individuals with overweight, obesity, prediabetes, or type 2 diabetes, including recruitment rate, retention safety, adherence, participants' attitudes, experiences, perspectives. Methods The authors searched MEDLINE, Embase, Cumulative Index Nursing Allied Health Literature from inception November 22, 2022, supplemented by backward forward citation search. Results From 4219 identified records, 28 studies were included. In general, was easy median rate 95% among <12 weeks duration 89% ≥12 weeks. Median (range) adherence the target window for (75%–98%) 81% (47%–93%), respectively. Variation participants considerable, indicating that following TRE difficult some people intervention conditions influenced adherence. These findings supported qualitative data synthetized seven studies, determinants included calorie‐free beverages outside window, provision support, influence window. No serious adverse events reported. Conclusions is implementable, acceptable, safe populations but it should be accompanied support options individual adjustments.
Язык: Английский
Процитировано
18
Trends in Endocrinology and Metabolism, Год журнала: 2023, Номер 35(2), С. 125 - 141
Опубликована: Окт. 28, 2023
Язык: Английский
Процитировано
18
Journal of Clinical Medicine, Год журнала: 2023, Номер 12(22), С. 7007 - 7007
Опубликована: Ноя. 9, 2023
Newer management strategies are being evaluated to treat obesity, which continues increase worldwide. After 12 h of fasting, the body switches from glucose fat metabolism, regulating protein synthesis and autophagy. These cellular responses central metabolic benefits time-restricted eating (TRE), independent calorie restriction weight loss, they have heightened interest in TRE regimens. Controversy remains, however, regarding We reviewed current literature concluded that is equivalent for loss has positive effects patients with diseases such as nonalcoholic fatty liver disease, cancer, cardiovascular disease.
Язык: Английский
Процитировано
15
Reviews in Endocrine and Metabolic Disorders, Год журнала: 2023, Номер 25(2), С. 325 - 337
Опубликована: Ноя. 22, 2023
Abstract Daily rhythms of metabolic function are supported by molecular circadian clock systems that strongly regulated feeding and fasting. Intermittent fasting diets have been associated with weight loss improved metabolism. However, the effects time-restricted eating (TRE) on glycemic parameters still under debate. In this review, we aim to systematically analyze TRE parameters. We searched PubMed, EMBASE, Cochrane Library for controlled studies in which subjects followed at least 4 weeks. 20 were included qualitative systematic 18 (n = 1169 subjects) meta-analysis. Overall, had no significant effect glucose (Hedges’s g -0.08; 95% CI:-0.31,0.16; p 0.52), but it did reduce HbA1c levels -0.27; CI: -0.47, -0.06; 0.01). significantly reduced insulin -0.40; -0.73,-0.08; 0.01) showed a tendency decrease HOMA-IR -0.32; CI:-0.66,0.02; 0.06). Interestingly, cumulative analysis beneficial regarding less apparent as later windows (lTRE) being included. Indeed, subgroup early (eTRE) revealed was eTRE -0.38; CI:-0.62, -0.14; < Our meta-analysis suggests can levels, timing food intake is crucial factor benefit TRE, only capable reducing overweight or obesity. PROSPERO registration number CRD42023405946.
Язык: Английский
Процитировано
11