Supramolecular assembly confined purely organic room temperature phosphorescence and its biological imaging

Chemical Science, Год журнала: 2022, Номер 13(27), С. 7976 - 7989

Опубликована: Янв. 1, 2022

Purely organic room temperature phosphorescence, especially in aqueous solution, is attracting increasing attention owing to its large Stokes shift, long lifetime, low preparation cost, toxicity, good processing performance advantages, and broad application value. This review mainly focuses on macrocyclic (cyclodextrin cucurbituril) hosts, nanoassembly, macromolecule (polyether) confinement-driven RTP. As an optical probe, the assembly two-stage strategy can realize confined purely RTP achieve energy transfer light-harvesting from fluorescence delayed or phosphorescence. supramolecular widely applied for luminescent materials, cell imaging, other fields because it effectively avoids oxygen quenching. In addition, near-infrared excitation, emission,

Язык: Английский

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Thermoresponsive Hydrogel‐Enabled Thermostatic Photothermal Therapy for Enhanced Healing of Bacteria‐Infected Wounds

Advanced Science, Год журнала: 2023, Номер 10(11)

Опубликована: Фев. 12, 2023

Abstract Photothermal therapy (PTT) has emerged as an attractive technique for the treatment of bacterial infections. However, uncontrolled heat generation in conventional PTT inevitably causes thermal damages to healthy tissues and/or organs. It is thus essential develop a smart and universal strategy regulate photothermal equilibrium temperature preset safe threshold. Herein, thermoresponsive hydrogel‐enabled thermostatic system enhanced healing bacteria‐infected wounds reported. In this system, near‐infrared (NIR)‐triggered by nanomaterials spontaneously transferred hydrogel with lower critical solution (LCST), leading its rapid phase transition forming considerable light‐scattering centers block NIR penetration. Such dynamic reversible process automatically regulates phase‐transition point LCST‐type hydrogel. contrast temperature‐uncontrolled severe damages, provides effective protection on organs, which remarkably accelerates wound efficient eradication. This study establishes smart, simple platform, holding great promise skin

Язык: Английский

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Colorful Triplet Excitons in Carbon Nanodots for Time Delay Lighting

Advanced Materials, Год журнала: 2023, Номер 35(21)

Опубликована: Фев. 25, 2023

Time delay lighting offers an added period of buffer illumination for human eyes upon switching off the light. Long-lifetime emission from triplet excitons has outstanding potential, but forbidden transition property due to Pauli exclusion principle makes them dark, and it stays challenging develop full-color bright excitons. Herein, ultraviolet (UV) near infrared (NIR) in carbon nanodots (CNDs) is achieved by confining multicolor CNDs emitters NaCNO crystal. crystal can isolate CNDs, quenching caused excited state electrons aggregation induced energy transfer suppressed, confinement furthermore promote phosphorescence inhibiting dissipation non-radiative transition. The radiative recombination covers spectral region 300 nm 800 (NIR), corresponding lifetimes reach 15.8, 818.0, 239.7, 168.4, 426.4, 127.6 ms. Furthermore, eco-friendly luminescent lampshades are designed based on phosphorescent time light-emitting diodes thus demonstrated. findings will motivate new opportunities development UV NIR applications.

Язык: Английский

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Molecular Engineering Powered Dual-Readout Point-of-Care Testing for Sensitive Detection of Escherichia coli O157:H7

ACS Nano, Год журнала: 2023, Номер 17(23), С. 23723 - 23731

Опубликована: Ноя. 27, 2023

Escherichia coli O157:H7 (E. O157:H7) has become one of the major threats to public health and food safety. However, culture method as a gold standard for detection E. requires laborious operations long processing time. Herein, we developed dual-readout aggregation-induced emission nanoparticle-based lateral flow immunoassay (LFIA) sensitive achieve qualitative quantitative assay satisfying applications under varying scenarios. 2,3-Bis(4-(bis(4-(tert-butyl)phenyl)amino)phenyl)fumaronitrile (BAPF), an luminogen, was designed strong molar extinction coefficient (3.0 × 104 M–1 cm–1) high quantum yield (33.28%), which further verified by large rotation angle low energy gap. Subsequently, BAPFs were integrated into nanostructured system form excellent water-soluble nanoparticles (BAPFNPs) with colorimetric fluorescent readout. The BAPFNPs-based LFIA (BAPFNPs-LFIA) exhibited nearly ability nanoparticles-LFIA (AuNPs-LFIA) 9 times enhancement compared beads-LFIA (QBs-LFIA) in aspect. Especially, FL-BAPFNPs-LFIA could detect earlier than QBs-LFIA AuNPs-LFIA when samples concentrations cultured. Overall, proposed strategy revealed that versatile BAPFNPs have great potential reporters enhancing sensitivity rapid accurate pathogenic bacteria assay.

Язык: Английский

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Exploring and leveraging aggregation effects on reactive oxygen species generation in photodynamic therapy

Aggregate, Год журнала: 2024, Номер 5(4)

Опубликована: Март 10, 2024

Abstract Aggregate‐level photodynamic therapy (PDT) has attracted significant interest and driven substantial advances in multifunction phototheranostic platforms. As exemplified by two typical instances of aggregation‐caused quenching reactive oxygen species (ROS) aggregation‐induced generation ROS, the aggregation effect plays a role on ROS photosensitizers (PSs), which is worthy in‐depth exploration full utilization. However, contrast to well‐developed researches luminescence, studies concerning are currently relatively nascent disjointed stage, lacking guidance from firmly established research paradigm. To advance this regard, review aims at providing consolidated overview fundamental principles status effects generation. Here, can be organized into main facets. One involves comparison between isolated state aggregated state, mainly conducted methods changing solvent environments adding adjuvants given solvent. The other underscores distinctions different aggregate states, consisting three parts, namely within same or categories based classification single‐component multicomponent aggregates. In endeavor, we will present our views current methodologies that explore how affects highlight design strategies leverage optimize PS regiments. We aspire propel advancement platforms accelerate clinical implementation precision medicine, inspire more contributions aggregate‐level photophysics photochemistry, pushing science materials forward.

Язык: Английский

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Donor–Acceptor Modulating of Ionic AIE Photosensitizers for Enhanced ROS Generation and NIR‐II Emission

Advanced Materials, Год журнала: 2024, Номер 36(28)

Опубликована: Апрель 25, 2024

Abstract Photosensitizers (PSs) with aggregation‐induced emission (AIE) characteristics are competitive candidates for bioimaging and therapeutic applications. However, their short wavelength nonspecific organelle targeting hinder effectiveness. Herein, a donor–acceptor modulation approach is reported to construct series of ionic AIE photosensitizers enhanced photodynamic therapy (PDT) outcomes fluorescent in the second near‐infrared (NIR‐II) window. By employing dithieno[3,2‐b:2′,3′‐d]pyrrole (DTP) indolium (In) as strong donor acceptor, respectively, compound DTP‐In exhibits substantial redshift absorption reach NIR‐II region. The reduced energy gap between singlet triplet states also increases reactive oxygen species (ROS) generation rate. Further, can self‐assemble aqueous solutions, forming positively charged nanoaggregates, which superior conventional encapsulated nanoparticles cellular uptake mitochondrial targeting. Consequently, aggregates show efficient ablation 4T1 cancer cells outstanding tumor theranostic vivo under 660 nm laser irradiation. This work highlights potential molecular engineering PSs multiple functionalities, thereby facilitating development more effective strategies therapy.

Язык: Английский

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Cell Membrane as A Promising Therapeutic Target: From Materials Design to Biomedical Applications

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(18)

Опубликована: Фев. 19, 2024

The cell membrane is a crucial component of cells, protecting their integrity and stability while facilitating signal transduction information exchange. Therefore, disrupting its structure or impairing functions can potentially cause irreversible damage. Presently, the tumor recognized as promising therapeutic target for various treatment methods. Given extensive research focused on membranes, it both necessary timely to discuss these developments, from materials design specific biomedical applications. This review covers treatments based functional targeting membrane, ranging well-known membrane-anchoring photodynamic therapy recent lysosome-targeting chimaeras protein degradation. diverse mechanisms are introduced in following sections: phototherapy, self-assembly situ biosynthesis degradation proteins by chimeras. In each section, we outline conceptual general derived numerous studies, emphasizing representative examples understand advancements draw inspiration. Finally, some challenges future directions membrane-targeted our perspective. aims engage multidisciplinary readers encourage researchers related fields advance fundamental theories practical applications membrane-targeting agents.

Язык: Английский

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Ion−π interactions for constructing organic luminescent materials

Aggregate, Год журнала: 2022, Номер 3(6)

Опубликована: Окт. 24, 2022

Abstract Organic luminescent materials are one of the research hotspots worldwide. The efficiency these can be tuned by introducing noncovalent interactions. Ion−π interactions, mainly including anion−π interactions and cation−π relatively new but powerful with extensive applications in supramolecular chemistry. use ion−π to fabricate highly is initiated since they were introduced develop aggregation‐induced emission luminogens 2017. Then, this field undergoing through challenging very prospective developments. In minireview, we start a brief introduction then make summary reports on organic fluorescence based room temperature phosphorescence induced bioimaging, imaging‐guided anticancer antibacterial treatment also discussed. challenges prospects using for constructing presented final part. It expected that minireview will provide some guidelines fabricating novel further extend application potential

Язык: Английский

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Research progress on AIE cyanostilbene-based self-assembly gels: Design, regulation and applications

Coordination Chemistry Reviews, Год журнала: 2022, Номер 471, С. 214753 - 214753

Опубликована: Авг. 9, 2022

Язык: Английский

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Tailoring the Amphiphilic Structure of Zwitterionic AIE Photosensitizers to Boost Antitumor Immunity

Advanced Materials, Год журнала: 2023, Номер 35(38)

Опубликована: Июнь 14, 2023

Although photodynamic therapy (PDT) for thorough cancer treatment is hindered by the limited generation of reactive oxygen species (ROS) with short lifetime from photosensitizers, PDT-induced antitumor immune response remedies defects. Previous studies show that inducing immunogenic cell deaths an attractive approach to activate immunity, which confers a robust adjuvanticity dying cells. In this work, amphiphilic luminogens aggregation-induced emission characteristics (AIEgens) are rationally designed and synthesized. By modulating hydrophobic π-bridge zwitterionic functional groups, these AIEgens exhibit tunable organelle specificity lysosome, endoplasmic reticulum, plasma membrane enhance ROS ability. Notably, membrane-targeting AIEgen namely TPS-2 induces death rupture via PDT facilitate release antigens activation Furthermore, size-controlled nanoaggregates found serve as adjuvant, promoting antigen accumulation delivery sufficiently boost in vivo immunity only one dose injection prophylactic tumor vaccination model. This work thus provides new insights into optimizing AIE photosensitizers hydrophobicity-hydrophilicity balance strategy evoking directly suppressing distanced tumor. A single small-molecular system PDT-stimulated envisioned.

Язык: Английский

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