Recent applications of immunomodulatory biomaterials for disease immunotherapy

Exploration, Journal Year: 2022, Volume and Issue: 2(6)

Published: May 23, 2022

Immunotherapy is used to regulate systemic hyperactivation or hypoactivation treat various diseases. Biomaterial-based immunotherapy systems can improve therapeutic effects through targeted drug delivery, immunoengineering, etc. However, the immunomodulatory of biomaterials themselves cannot be neglected. In this review, we outline with functions discovered in recent years and their applications disease treatment. These inflammation, tumors, autoimmune diseases by regulating immune cell function, exerting enzyme-like activity, neutralizing cytokines, The prospects challenges biomaterial-based modulation are also discussed.

Language: Английский

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Naturally sourced hydrogels: emerging fundamental materials for next-generation healthcare sensing

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(9), P. 2992 - 3034

Published: Jan. 1, 2023

The flourishing development of flexible healthcare sensing systems is inseparable from the fundamental materials with application-oriented mechanical and electrical properties. Thanks to continuous inspiration our Mother Nature, hydrogels originating natural biomass are attracting growing attention for their structural functional designs owing unique chemical, physical biological These highly efficient architectural enable them be most promising candidates electronic devices. This comprehensive review focuses on recent advances in naturally sourced constructing multi-functional sensors applications thereof. We first briefly introduce representative polymers, including polysaccharides, proteins, polypeptides, summarize physicochemical design principles fabrication strategies hydrogel based these polymers outlined after material properties required presented. then highlight various techniques devices, illustrate examples wearable or implantable bioelectronics pressure, strain, temperature, biomarker field systems. Finally, concluding remarks challenges prospects hydrogel-based provided. hope that this will provide valuable information next-generation build a bridge between as matter an applied target accelerate new near future.

Language: Английский

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Nanochitin and Nanochitosan: Chitin Nanostructure Engineering with Multiscale Properties for Biomedical and Environmental Applications

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(4)

Published: May 31, 2022

Nanochitin and nanochitosan (with random-copolymer-based multiscale architectures of glucosamine N-acetylglucosamine units) have recently attracted immense attention for the development green, sustainable, advanced functional materials. are materials from small oligomers, rod-shaped nanocrystals, longer nanofibers, to hierarchical assemblies nanofibers. Various physical properties chitin chitosan depend on their molecular- nanostructures; translational research has utilized them a wide range applications (biomedical, industrial, environmental, so on). Instead reviewing entire extensive literature chitosan, here, recent developments in multiscale-dependent material highlighted; immune, medical, reinforcing, adhesive, green electrochemical materials, biological scaffolds, sustainable food packaging discussed considering size, shape, assembly nanostructures. In summary, new perspectives based nanochitin by understanding engineering described.

Language: Английский

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Design the molecule structures to achieve functional advantages of hydrogel wound dressings: Advances and strategies

Composites Part B Engineering, Journal Year: 2022, Volume and Issue: 247, P. 110313 - 110313

Published: Oct. 4, 2022

Language: Английский

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Charge-reversible and biodegradable chitosan-based microgels for lysozyme-triggered release of vancomycin

Journal of Advanced Research, Journal Year: 2022, Volume and Issue: 43, P. 87 - 96

Published: Feb. 24, 2022

High-dose drug administration for the conventional treatment of inflammatory bowel disease induces cumulative toxicity and serious side effects. Currently, few reports have introduced smart carriers intestinal inflammation targeting toward disease. For unique lysozyme secretory microenvironment inflamed intestine, vancomycin-loaded chitosan-polyaniline microgels (CH-PANI MGs) were constructed lysozyme-triggered VM release. Aniline was first grafted to chitosan form polymers that crosslinked by glutaraldehyde achieve CH-PANI MGs using inverse (water-in-oil) miniemulsion method. Interestingly, exhibit polyampholyte behaviour display charge-reversible (positive negative charges) after with a NaCl solution. The formed negatively charged N-CH-PANI MG aqueous solution is employed load cationic vancomycin satisfactory loading efficiency 91.3%, which significantly higher than chitosan-based MGs. Moreover, present biodegradation controllable release upon cleavage glycosidic linkages chitosan. In simulated microenvironment, rapidly released, reaches approximately 76.9%. Remarkably, N-CH-PANI@VM not only high resistance harsh gastric acidity but also prevent premature leakage in healthy gastrointestinal tract. Encouragingly, show obvious antibacterial activity against Staphylococcus aureus at relatively low concentration 20 μg/mL. Compared other pH-responsive used treat disease, key advantage lysozyme-responsive they further specifically identify intestines, achieving efficient With this excellent performance, developed might be as potential oral delivery system treatment.

Language: Английский

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Oral delivery of protein and peptide drugs: from non-specific formulation approaches to intestinal cell targeting strategies

Theranostics, Journal Year: 2022, Volume and Issue: 12(3), P. 1419 - 1439

Published: Jan. 1, 2022

The past few years has witnessed a booming market of protein and peptide drugs, owing to their superior efficiency biocompatibility.Parenteral route is the most commonly employed method for drugs administration.However, short plasma half-life requires repetitive injections results in poor patient compliance.Oral delivery promising alternative but hindered by harsh gastrointestinal environment defensive intestinal epithelial barriers.Therefore, designing suitable oral systems been persistent challenge.This review summarizes main challenges highlights advanced formulation strategies improve bioavailability.More importantly, major cell types available targeting receptors are introduced along with potential target these types.We also described multifunctional biomaterials which can be used prepare carrier as well modulate mucosal immune response.Understanding emerging will surely inspire production that serves therapeutic needs clinical settings.

Language: Английский

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Polysaccharide 3D Printing for Drug Delivery Applications

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(1), P. 145 - 145

Published: Jan. 7, 2022

3D printing, or additive manufacturing, has gained considerable interest due to its versatility regarding design as well in the large choice of materials. It is a powerful tool field personalized pharmaceutical treatment, particularly crucial for pediatric and geriatric patients. Polysaccharides are abundant inexpensive natural polymers, that already widely used food industry excipients cosmetic formulations. Due their intrinsic properties, such biocompatibility, biodegradability, non-immunogenicity, etc., polysaccharides largely investigated matrices drug delivery. Although an increasing number interesting reviews on manufacturing delivery being published, there gap concerning printing polysaccharides. In this article, we will review recent advances focused applications. Among family polysaccharides, present focus cellulose derivatives, chitosan sodium alginate, printed by fused deposition modeling extrusion-based printing.

Language: Английский

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Ferroptosis‐Enhanced Immunotherapy with an Injectable Dextran‐Chitosan Hydrogel for the Treatment of Malignant Ascites in Hepatocellular Carcinoma

Advanced Science, Journal Year: 2023, Volume and Issue: 10(20)

Published: May 3, 2023

Abstract Malignant ascites in advanced hepatocellular carcinoma (HCC) is a complex clinical problem that lacks effective treatments. Due to the insensitivity of HCC cells traditional chemotherapies, low drug accumulation, and limited residence time peritoneal cavity, therapeutic effects malignant are not satisfactory. In this study, an injectable hydrogel delivery system based on chitosan hydrochloride oxidized dextran (CH‐OD) designed load sulfasalazine (SSZ), FDA‐approved with ferroptosis‐inducing ability, for tumor‐killing activation anti‐tumor immunity. Compared free SSZ, SSZ‐loaded CH‐OD (CH‐OD‐SSZ) exhibits greater cytotoxicity induces higher levels immunogenic ferroptosis. preclinical model hepatoma ascites, intraperitoneal administration CH‐OD‐SSZ can significantly suppress tumor progression improve immune landscape. Both vitro vivo, repolarization macrophages M1‐like phenotype promotes maturation dendritic cells. Combination treatment anti‐programmed cell death protein 1 (PD‐1) immunotherapy achieves more than 50% regression generates long‐term memory. Collectively, promising potential dissemination HCC, especially when combined anti‐PD‐1 immunotherapy.

Language: Английский

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Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(8), P. 4086 - 4153

Published: Jan. 1, 2024

This review critically analyzes degradable biomedical elastomers, focusing on their degradation, synthesis, microstructure, and role in tissue repair. It guides experts balancing degradation with repair for improved applications.

Language: Английский

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Catalytic Approaches to Chemo- and Site-Selective Transformation of Carbohydrates

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(10), P. 6793 - 6838

Published: April 26, 2023

Carbohydrates are a fundamental unit playing pivotal roles in all the biological processes. It is thus essential to develop methods for synthesizing, functionalizing, and manipulating carbohydrates further understanding of their functions creation sugar-based functional materials. is, however, not trivial such methods, since densely decorated with polar similarly reactive hydroxy groups stereodefined manner. New approaches chemo- site-selective transformations are, therefore, great significance revolutionizing sugar chemistry enable easier access sugars interest. This review begins brief overview innate reactivity carbohydrates. followed by discussions about catalytic enhance, override, or be orthogonal transformation avoids making list reactions, but rather focuses on summarizing concept behind each reported transformation. The literature references were sorted into sections based underlying ideas approaches, which we hope will help readers have better sense current state innovative field.

Language: Английский

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