Recent Advances in Site Selective Transformations of β-Enaminones via C-H Functionalization/Annulation

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

β-Enaminone transformation strategies are widely employed in the synthesis of numerous biologically active drugs and natural products, highlighting their significance medicinal chemistry.

Язык: Английский

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Recent Advances in Domino Synthesis of Fused Polycyclic N‐Heterocycles Based on Intramolecular Alkyne Hydroamination under Copper Catalysis

Chinese Journal of Chemistry, Год журнала: 2023, Номер 41(24), С. 3751 - 3771

Опубликована: Сен. 4, 2023

Comprehensive Summary Fused polycyclic N ‐heterocycles are very important scaffolds in biomedicinal chemistry and materials science. Intramolecular alkyne hydroamination is a powerful method for the construction of ‐heterocycles. In last two decades, copper‐catalyzed domino reactions based on intramolecular has emerged as robust strategy assembling various fused Great progress been achieved this area. This short review covers advances made synthesis from 2008 to 2023, will hopefully serve an inspiration towards exploration new versions transformation. The transformations introduced discussed five aspects according different key processes involved these reactions.

Язык: Английский

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Electrochemical cascade pyrazole annulation and C-H halogenation for the synthesis of 4-halopyrazoles

Green Synthesis and Catalysis, Год журнала: 2023, Номер unknown

Опубликована: Окт. 1, 2023

The synthesis of 4-halo-functionalized pyrazoles by electrochemical cascade reactions between N,N-dimethyl enaminones and proper hydrazine reagents in the presence a halogen source is realized at room temperature. work provides tunable efficient accesses to 4-chloro- 4-bromopyrazoles aqueous THF (tetrahydrofuran) without using any transition metal reagent.

Язык: Английский

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Rh‐catalyzed three‐component synthesis of diverse N‐aryl pyrazoles via cascade pyrazole annulation and aryl C‐H addition to alkenes

Applied Organometallic Chemistry, Год журнала: 2024, Номер 38(9)

Опубликована: Июль 5, 2024

A novel Rh‐catalyzed three‐component synthesis of N ‐( o ‐alkylaryl) pyrazoles via cascade pyrazole annulation and aryl C‐H conjugate addition to alkenes has been developed with enaminones, hydrazines, functionalized as starting materials. The raw materials used in this reaction are simple, cheap, readily available, the reactions feature excellent step economy by furnishing products formation a ring key activation one‐step operation. Moreover, proceeds smoothly under air atmosphere, making it easy operate.

Язык: Английский

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Synthesis of C2-Spiroindolines Based on the Cascade Reaction of 2-Aryl-3H-indoles with Cyclopropanols

Chinese Journal of Organic Chemistry, Год журнала: 2025, Номер 45(2), С. 694 - 694

Опубликована: Янв. 1, 2025

Язык: Английский

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[3 + 2] Cycloaddition of N-Amino(iso)quinolinium Salts with Vinylsulfonium Salt: Synthesis of Pyrazolo[1,5-a]quinoline and Pyrazolo[5,1-a]isoquinoline Derivatives

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 16, 2025

In this study, we reported the utilization of vinylsulfonium salt as a highly efficient dipolarophile, leveraging facile leaving ability its sulfide moiety, to engage in [3 + 2] cycloaddition with N-amino(iso)quinolinium salts. This approach facilitates construction various C1/C2-unsubstituted pyrazolo(iso)quinoline skeletons. The transformation is conducted under catalyst- and external oxidant-free conditions. Furthermore, extended gram-scale reaction demonstrates practical applicability developed protocol.

Язык: Английский

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Construction of 1,4-Dihydropyridines: The Evolution of C4 Source

Topics in Current Chemistry, Год журнала: 2023, Номер 381(5)

Опубликована: Сен. 25, 2023

Язык: Английский

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Transition Metal‐Catalyzed Dual C−H Activation/Annulation Reactions Involving Internal Alkynes

The Chemical Record, Год журнала: 2024, Номер 24(7)

Опубликована: Июль 1, 2024

Recently, transition metal-catalyzed ortho-C-H bond activation/annulations involving two internal alkyne molecules have been extensively used to synthesize highly substituted polycyclic aromatic scaffolds. Such reactions emerged as a powerful atom and step-economical strategy for the assembly of multifunctional bioactive molecules. In this context, we focused on recent achievements dual C-H activation/annulations, well functionalization diaryl/alkyl alkynes.

Язык: Английский

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Synthesis of pyrazoles from sulfonyl hydrazone and benzyl acrylate under transition-metal-free conditions

Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 21(37), С. 7611 - 7615

Опубликована: Янв. 1, 2023

DBU-mediated [3 + 2] cycloaddition reaction for the synthesis of pyrazoles. It is noteworthy that this constructed two new C–N bonds and a C–C bond at same time, providing door construction functionalization pyrazole scaffolds.

Язык: Английский

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Palladium-Catalyzed Direct Esterification via C–H Bond Activation of Aldehydes

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(13), С. 9026 - 9036

Опубликована: Июнь 12, 2023

A concise and highly efficient synthesis method of direct esterification aldehydes via Pd-catalyzed C–H bond activation aldehyde group has been developed. The strategy avoids the preoxidation step or use condensing agents in ester synthesis, which is not only applicable to various alcohols but also suitable for phenolics are usually difficult be esterified. methodology significant advantages broad substrate scope, mild reaction conditions, nonrequirement additional oxidants.

Язык: Английский

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