Abstract
This
review
delves
into
the
innovative
field
of
interfacial
photoelectrochemical
(iPEC)
and
(PEC)
catalysis,
dynamic
synthesis
methodologies
that
seamlessly
integrates
electrochemical
photoredox
catalysis
for
efficient
environmentally
friendly
reactions.
Utilizing
minute
quantities
photocatalysts,
visible
light
becomes
a
powerful
tool,
generating
transient
excited
states
to
catalyze
spectrum
reactions
through
single‐electron
oxidation
or
reduction
events.
The
categorizes
recent
advancements,
highlighting
applications
in
organic
synthesis,
late‐stage
modifications,
distinctive
features
methodology.
Despite
being
its
early
stages,
this
synergistic
approach
holds
great
promise
propelling
forward,
with
potential
large‐scale
diverse
functionalizations,
including
asymmetric
bioconjugation
strategies
biomolecule
modifications.
Chemical Reviews,
Год журнала:
2023,
Номер
123(19), С. 11269 - 11335
Опубликована: Сен. 26, 2023
Late-stage
functionalization
(LSF)
constitutes
a
powerful
strategy
for
the
assembly
or
diversification
of
novel
molecular
entities
with
improved
physicochemical
biological
activities.
LSF
can
thus
greatly
accelerate
development
medicinally
relevant
compounds,
crop
protecting
agents,
and
functional
materials.
Electrochemical
synthesis
has
emerged
as
an
environmentally
friendly
platform
transformation
organic
compounds.
Over
past
decade,
electrochemical
late-stage
(eLSF)
gained
major
momentum,
which
is
summarized
herein
up
to
February
2023.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(11), С. 2830 - 2848
Опубликована: Янв. 1, 2023
Recent
advances
in
the
electrochemical
generation
of
1,3-dicarbonyl
radicals
from
C–H
bonds
and
their
mechanistic
insights
synthetic
applications
have
been
summarized.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(19), С. 13610 - 13621
Опубликована: Сен. 11, 2023
An
electrophilic
spirocyclization
of
N-benzylacrylamides
with
N-halosuccinimides
(NXS)
as
the
halogenating
reagents
has
been
developed.
This
reaction
is
carried
out
at
room
temperature
under
simple
conditions
without
relying
on
metal
reagents,
photochemistry,
or
electrochemistry,
providing
a
fast
and
efficient
route
to
synthesize
wide
variety
4-halomethyl-2-azaspiro[4.5]decanes
satisfactory
yields.
The
approach
further
highlighted
through
gram-scale
synthesis
diverse
transformations
spiro
products.
Organic Letters,
Год журнала:
2023,
Номер
25(38), С. 7014 - 7019
Опубликована: Сен. 18, 2023
Organoelectrophotocatalytic
generation
of
acyl
radicals
from
formamides
and
aldehydes
to
synthesize
acylated
3-CF3-2-oxindoles
has
been
developed.
This
protocol
features
a
monocatalytic
system
using
9,10-phenanthrenequinone
(PQ)
both
as
catalyst
hydrogen
atom
transfer
(HAT)
reagent,
which
avoids
the
use
an
external
HAT
metal
oxidant.
A
variety
have
obtained
in
satisfactory
yields
CF3-substituted
N-arylacrylamides
via
tandem
radical
cyclization.
ACS Catalysis,
Год журнала:
2023,
Номер
13(13), С. 8731 - 8751
Опубликована: Июнь 16, 2023
Electrochemically
driven
hydrogen
atom
transfer
(HAT)
catalysis
provides
a
complementary
approach
for
the
transformation
of
redox-inactive
substrates
that
would
be
inaccessible
to
conventional
electron
(ET)
catalysis.
Moreover,
electrochemically
HAT
could
promote
organic
transformations
with
either
abstraction
or
donation
as
key
step.
It
versatile
and
effective
tool
direct
functionalization
C(sp3)–H/Si–H
bonds
hydrofunctionalization
alkenes.
Despite
these
attractive
properties,
has
been
largely
overlooked
due
lack
understanding
both
catalytic
mechanism
how
catalyst
selection
should
occur.
In
this
Review,
we
give
an
overview
applications
in
The
mechanistic
pathways,
physical
properties
mediators,
state-of-the-art
examples
are
described
discussed.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(14), С. 3585 - 3590
Опубликована: Янв. 1, 2023
An
organophotoelectrochemical
approach
for
silylation
cyclization
of
CF3-substituted
N
-arylacrylamides
with
organosilanes
under
transition-metal-free
and
oxidant-free
conditions
has
been
developed.
Chemical Communications,
Год журнала:
2024,
Номер
60(42), С. 5502 - 5505
Опубликована: Янв. 1, 2024
An
organophotoelectrocatalytic
method
for
the
C(sp
2
)–H
alkylation
of
heteroarenes
with
unactivated
3
compounds
via
dehydrogenation
cross-coupling
was
developed.
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
42(16), С. 1913 - 1928
Опубликована: Апрель 24, 2024
Comprehensive
Summary
Organic
fluorine
compounds
are
ubiquitous
and
pivotally
important
organic
molecules,
yet
their
activation
transformation
have
long
been
a
formidable
challenge
due
to
the
high
energy
low
reactivity
of
C—F
bonds.
electrosynthesis,
an
environmentally
benign
synthetic
method
in
chemistry,
enables
myriad
chemical
transformations
without
need
for
external
redox
reagents.
In
recent
years,
electrochemistry
has
emerged
as
powerful
tool
achieving
bonds
fluorine‐containing
compounds.
This
review
aims
succinctly
recapitulate
latest
advancements
electrochemical
defluorinative
delve
into
reaction
design,
mechanistic
insights,
developmental
prospects
these
methods.
Key
Scientists
1959,
Lund
was
first
pioneer
electroreduction
CF
3
CH
group.
Electrochemistry
lately
provided
new
opportunities
efficient
conversion
fluorides.
2020,
Zhou
coworkers
discovered
carboxylation
α‐CF
alkenes.
Lambert
colleagues
reported
electrophotocatalytic
amination
aryl
Electrochemical
hydrodefluorination
trifluoromethylketones
developed
by
Lennox
2021.
same
year,
Wang
Guo
disclosed
radical
alkylation
alkenes
with
Katritzky
salts
alkyl
precursors.
Subsequently,
Wu
Liao
described
transition‐metal‐free,
site‐selective
arylation
polyfluoroarenes
(het)arenes
using
paired
electrophotocatalysis.
2023,
numerous
efforts
were
made
achieve
bond
activation.
Xia
organoboron‐controlled
chemoselective
sequential
(deutero)hydrodefluorination
trifluoroacetamides.
