Nanoscale, Год журнала: 2021, Номер 13(40), С. 17168 - 17182
Опубликована: Янв. 1, 2021
A near-infrared light-responsive hybrid hydrogel was injected in the tumor site. IR820 could not only produce local heat for photothermal therapy, but also generate singlet oxygen to induce degradation of MSNs controllable drug release.
Язык: Английский
Frontiers in Bioengineering and Biotechnology, Год журнала: 2022, Номер 10
Опубликована: Янв. 25, 2022
Tissue repair after trauma and infection has always been a difficult problem in regenerative medicine. Hydrogels have become one of the most important scaffolds for tissue engineering due to their biocompatibility, biodegradability water solubility. Especially, stiffness hydrogels is key factor, which influence morphology mesenchymal stem cells (MSCs) differentiation. The researches on this point are meaningful field engineering. Herein, review focus design with different effects behavior MSCs. In addition, effect hydrogel phenotype macrophages introduced, then relationship between changes inflammatory response discussed. Finally, future application certain medicine prospected.
Язык: Английский
Процитировано
114
Bioactive Materials, Год журнала: 2024, Номер 38, С. 346 - 373
Опубликована: Май 9, 2024
Gelatin methacryloyl (GelMA) hydrogels is a widely used bioink because of its good biological properties and tunable physicochemical properties, which has been in variety tissue engineering regeneration. However, pure GelMA limited by the weak mechanical strength lack continuous osteogenic induction environment, difficult to meet needs bone repair. Moreover, are unable respond complex stimuli therefore adapt physiological pathological microenvironments. This review focused on functionalization strategies hydrogel based bioinks for The synthesis process was described details, various functional methods requirements regeneration, including strength, porosity, vascularization, differentiation, immunoregulation patient specific repair, etc. In addition, response smart GelMA-based external physical stimulation internal microenvironment stimulation, as well achieve both disease treatment regeneration presence common diseases (such inflammation, infection, tumor) also briefly reviewed. Finally, we emphasized current challenges possible exploration directions
Язык: Английский
Процитировано
30
Biomaterials Science, Год журнала: 2024, Номер 12(5), С. 1151 - 1170
Опубликована: Янв. 1, 2024
This review summarizes composition and preparation methodologies of injectable hydrogels highlights the delivery mechanisms drugs for tumor therapy, along with discussion on optimal therapeutic efficiency provides perspective challenges solutions in applications.
Язык: Английский
Процитировано
18
Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 686 - 714
Опубликована: Фев. 17, 2025
Язык: Английский
Процитировано
2
Biomaterials Advances, Год журнала: 2022, Номер 133, С. 112641 - 112641
Опубликована: Янв. 7, 2022
Язык: Английский
Процитировано
60
International Journal of Pharmaceutics, Год журнала: 2022, Номер 616, С. 121534 - 121534
Опубликована: Фев. 3, 2022
Язык: Английский
Процитировано
47
Materials, Год журнала: 2023, Номер 16(3), С. 1303 - 1303
Опубликована: Фев. 3, 2023
Bone regeneration has gained attention in the biomedical field, which led to development of materials and synthesis methods meant improve osseointegration cellular bone activity. The properties hydroxyapatite, a type calcium phosphate, have been researched determine its advantages for tissue engineering, particularly biocompatibility ability interact with cells. Recently, utilizing nanomolecules combined various substances, order enhance combine their characteristics, reported literature. This review will outline molecular roles hydroxypatite, interactions cells, nano-combinations ions natural products effects on growth, development, repair.
Язык: Английский
Процитировано
40
Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)
Опубликована: Дек. 3, 2022
Abstract Norcantharidin (NCTD) is a demethylated derivative of cantharidin (CTD), the main anticancer active ingredient isolated from traditional Chinese medicine Mylabris. NCTD has been approved by State Food and Drug Administration for treatment various solid tumors, especially liver cancer. Although greatly reduces toxicity CTD, there still certain degree urinary organ toxicity, poor solubility, short half-life, fast metabolism, as well high venous irritation weak tumor targeting ability limit its widespread application in clinic. To reduce improve efficacy, design targeted drug delivery systems based on biomaterials nanomaterials one most feasible strategies. Therefore, this review focused studies combined with recent years, including passive systems, physicochemical improving bioavailability enhancing increasing reducing adverse effects. Graphical
Язык: Английский
Процитировано
39
Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 200, С. 115003 - 115003
Опубликована: Июль 6, 2023
Язык: Английский
Процитировано
35
Pharmaceutics, Год журнала: 2023, Номер 15(5), С. 1334 - 1334
Опубликована: Апрель 25, 2023
With the in-depth understanding of bone regeneration mechanisms and development tissue engineering, a variety scaffold carrier materials with desirable physicochemical properties biological functions have recently emerged in field regeneration. Hydrogels are being increasingly used engineering because their biocompatibility, unique swelling properties, relative ease fabrication. Hydrogel drug delivery systems comprise cells, cytokines, an extracellular matrix, small molecule nucleotides, which different depending on chemical or physical cross-linking. Additionally, hydrogels can be designed for types specific applications. In this paper, we summarize recent research using as carriers, detail application defect diseases mechanisms, discuss future directions hydrogel engineering.
Язык: Английский
Процитировано
33