Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 95, С. 105604 - 105604
Опубликована: Март 21, 2024
Язык: Английский
ACS Nano, Год журнала: 2021, Номер 15(12), С. 20377 - 20390
Опубликована: Дек. 3, 2021
Development of innovative nanomedicine formulations to traverse the blood–brain barrier (BBB) for effective theranostics glioma remains a great challenge. Herein, we report creation macrophage membrane-camouflaged multifunctional polymer nanogels coloaded with manganese dioxide (MnO2) and cisplatin magnetic resonance (MR) imaging-guided chemotherapy/chemodynamic therapy (CDT) orthotopic glioma. Redox-responsive poly(N-vinylcaprolactam) (PVCL) (NGs) formed via precipitation polymerization were in situ loaded MnO2 physically encapsulated have mean size 106.3 nm coated membranes good colloidal stability. The generated hybrid NGs display dual pH- redox-responsive Mn(II) release profiles can deplete glutathione (GSH) rich tumor microenvironment through reaction disulfide-containing cross-linkers within MnO2. thus created enables enhanced CDT Fenton-like T1-weighted MR imaging, while not only exerts its chemotherapy effect but also promotes reactive oxygen species generation enhance efficacy. Importantly, membrane coating rendered prolonged blood circulation time ability BBB specific targeted chemotherapy/CDT Our study demonstrates promising self-adaptive cooperative NG-based platform highly efficient glioma, which may be extended tackle other difficult cancer types.
Язык: Английский
Процитировано
165
Advanced Materials, Год журнала: 2022, Номер 34(52)
Опубликована: Апрель 6, 2022
Cancer is one of the most intractable diseases owing to its high mortality rate and lack effective diagnostic treatment tools. Advancements in micro-/nanorobot (MNR)-assisted sensing, imaging, therapeutics offer unprecedented opportunities develop MNR-based cancer theragnostic platforms. Unlike ordinary nanoparticles, which exhibit Brownian motion biofluids, MNRs overcome viscous resistance an ultralow Reynolds number (Re << 1) environment by self-propulsion. This unique locomotion property has motivated advanced design functionalization as a basis for next-generation cancer-therapy platforms, potential precise distribution improved permeation therapeutic agents. Enhanced barrier penetration, imaging-guided operation, biosensing are additionally studied enable promising cancer-related applications MNRs. Herein, recent advances therapy comprehensively addresses, including actuation engines, diagnostics, medical targeted drug delivery; research that can have profound impact on over next decade highlighted.
Язык: Английский
Процитировано
87
Chemical Science, Год журнала: 2022, Номер 13(8), С. 2202 - 2217
Опубликована: Янв. 1, 2022
This review summarizes the current progress of redox dyshomeostasis (RDH) strategy for tumor therapy. makes cells more sensitive to therapy patterns through using nanomaterials disrupt homeostasis.
Язык: Английский
Процитировано
72
BMEMat, Год журнала: 2023, Номер 1(2)
Опубликована: Фев. 25, 2023
Abstract A major bottleneck underlying nanomaterial‐based tumor therapy lies in complex biological environment and physiological barriers. Micro/nanorobots with the features of self‐propulsion controllable navigation have gradually become a research hotspot therapeutic community, exhibiting their advantages efficient cargo loading, delivery, stimuli‐triggered release, deeper tissue penetration, enhanced accumulation tissue. In this review, are introduced as two properties micro/nanorobots, which micro/nanorobots propelled by chemical reactions, physical fields, systems could be navigated chemotaxis, remote magnetic guidance, light. Then, recent advances for chemotherapy, immunotherapy, photothermal therapy, photodynamic chemodynamic multimodal would discussed. Finally, perspective challenges also mentioned. It is expected that review gives an insight into intelligent improved aiming more extensive in‐depth investigations, final applications clinic.
Язык: Английский
Процитировано
55
Advanced Functional Materials, Год журнала: 2024, Номер 34(18)
Опубликована: Янв. 23, 2024
Abstract Cuproptosis, a newly discovered cell death pathway, has shown great potential in cancer treatment. Herein, near‐infrared (NIR) light‐driven nanomotors (CuSiO 3 @Au‐Pd NMs) are designed for cuproptosis‐assisted synergistic therapy with autonomous mobility and improved cellular uptake tumor penetration. Specifically, the released Cu 2+ ions from CuSiO NMs can induce Fenton‐like reaction, leading to generation of hydroxyl radicals (·OH), accompanied by depletion glutathione within MCF‐7 cells. Additionally, also exhibit excellent photothermal effects, which further promote production ·OH, resulting intensified oxidative stress apoptosis. Moreover, enhanced permeation efficiency via movement under self‐thermophoretic forces proved using 2D experiments 3D multicellular spheroids. The resultant intracellular accumulation oligomerization lipoylated proteins, cuproptosis, along mitochondrial dysfunction pathway. More importantly, both vitro vivo show that could penetrate deeply into tumors anticancer efficacy through multimodal therapeutic methods. These findings manifest promising potentials NIR‐powered Cu‐based high maneuverability future smart therapy.
Язык: Английский
Процитировано
30
Advanced Materials, Год журнала: 2024, Номер 36(21)
Опубликована: Фев. 16, 2024
Immunotherapy represents a revolutionary paradigm in cancer management, showcasing its potential to impede tumor metastasis and recurrence. Nonetheless, challenges including limited therapeutic efficacy severe immune-related side effects are frequently encountered, especially solid tumors. Hydrogels, class of versatile materials featuring well-hydrated structures widely used biomedicine, offer promising platform for encapsulating releasing small molecule drugs, biomacromolecules, cells controlled manner. Immunomodulatory hydrogels present unique capability augmenting immune activation mitigating systemic toxicity through encapsulation multiple components localized administration. Notably, based on biopolymers have gained significant interest owing their biocompatibility, environmental friendliness, ease production. This review delves into the recent advances bio-based immunotherapy synergistic combinatorial approaches, highlighting diverse applications. It is anticipated that this will guide rational design field immunotherapy, fostering clinical translation ultimately benefiting patients.
Язык: Английский
Процитировано
26
Small, Год журнала: 2024, Номер 20(25)
Опубликована: Янв. 25, 2024
Abstract The growth state of tumor cells is strictly affected by the specific abnormal redox status microenvironment (TME). Moreover, reactions at biological level are also central and fundamental to essential energy metabolism in tumors. Accordingly, anti‐tumor nanodrugs targeting disruption this homeostasis have become one hot spots field research due effectiveness TME modulation efficiency mediated interference. This review discusses latest results therapy, which regulate levels oxidants or reductants through a variety therapeutic strategies, ultimately breaking original “stable” promoting cell death. With gradual deepening study on vigorous development nanomaterials, it expected that more nano drugs based regulation will be designed even applied clinically.
Язык: Английский
Процитировано
20
Nano Today, Год журнала: 2024, Номер 55, С. 102212 - 102212
Опубликована: Фев. 26, 2024
Язык: Английский
Процитировано
20
Advanced Science, Год журнала: 2022, Номер 10(4)
Опубликована: Ноя. 14, 2022
Increasing O
Язык: Английский
Процитировано
61
Small Methods, Год журнала: 2022, Номер 6(9)
Опубликована: Авг. 17, 2022
Abstract Chemodynamic therapy (CDT) is an effective cancer treatment that uses Fenton reaction to induce cell death. Current clinical applications of CDT are limited by the dependency external supply metal ions as well low catalytic efficiency. Here, a highly efficient metal‐free using endoperoxide bridge‐containing artesunate free radical‐generating substance developed. A Pt(IV) prodrug (A‐Pt) containing two molecules in axial direction synthesized, which can be decomposed into cisplatin and under reducing intracellular environment tumor cells. To improve efficiency for reaction, near‐infrared‐II (NIR‐II) photothermal agent IR1048 incorporated achieve mild hyperthermia effect. By encapsulating A‐Pt with human serum albumin, A‐Pt‐IR NP formulated drug delivery 4T1 tumor‐bearing mice. NIR‐II light irradiation treated mice show accelerated reaction. In addition, could also strong immunogenic death, effectively reverses immunosuppressive microenvironment, augments antitumor immunity. This study demonstrates potent biodegradable active chemotherapy/CDT nanomedicine translation.
Язык: Английский
Процитировано
43