Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Дек. 27, 2022

Abstract Synthetic nanoparticles with surface bioconjugation are promising platforms for targeted therapy, but their simple biological functionalization is still a challenging task against the complex intercellular environment. Once synthetic enter body, they phagocytosed by immune cells system. Recently, cell membrane camouflage strategy has emerged as novel therapeutic tactic to overcome these issues utilizing fundamental properties of natural cells. Macrophage, type system cells, plays critical roles in various diseases, including cancer, atherosclerosis, rheumatoid arthritis, infection and inflammation, due recognition engulfment function removing substances pathogens. Macrophage membranes inherit protein profiles biointerfacing source Therefore, macrophage cloaking can protect from phagocytosis Meanwhile, make use correspondence accurately recognize antigens target inflamed tissue or tumor sites. In this review, we have summarized advances fabrication, characterization homing capacity cancers, cardiovascular central nervous microbial infections. Although membrane-camouflaged currently fetal stage development, there huge potential challenge explore conversion mode clinic.

Язык: Английский

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An Intelligent Cell-Derived Nanorobot Bridges Synergistic Crosstalk Between Sonodynamic Therapy and Cuproptosis to Promote Cancer Treatment

Nano Letters, Год журнала: 2023, Номер 23(7), С. 3038 - 3047

Опубликована: Март 23, 2023

Recent progress in cuproptosis sheds light on the development of treatment approaches for advancing sonodynamic therapy (SDT) due to its unique cell death mechanism. Herein, we elaborately developed an intelligent cell-derived nanorobot (SonoCu), composed macrophage-membrane-camouflaged nanocarrier encapsulating copper-doped zeolitic imidazolate framework-8 (ZIF-8), perfluorocarbon, and sonosensitizer Ce6, synergistically triggering cuproptosis-augmented SDT. SonoCu not only improved tumor accumulation cancer-cell uptake through cell-membrane camouflaging but responded ultrasound stimuli enhance intratumor blood flow oxygen supply, which consequently overcame barriers activated cuproptosis. Importantly, SDT effectiveness could be further amplified by multiple mechanisms, including reactive species accumulation, proteotoxic stress, metabolic regulation, sensitized cancer death. Particularly, exhibited ultrasound-responsive cytotoxicity against cells healthy cells, endowing it with good biosafety. Therefore, present first anticancer combination cuproptosis, may inspire studies pursuing a rational multimodal strategy.

Язык: Английский

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Chemotherapy Mediated by Biomimetic Polymeric Nanoparticles Potentiates Enhanced Tumor Immunotherapy via Amplification of Endoplasmic Reticulum Stress and Mitochondrial Dysfunction

Advanced Materials, Год журнала: 2022, Номер 34(47)

Опубликована: Сен. 20, 2022

Construction of multifunctional nanoplatforms to elevate chemotherapeutic efficacy and induce long-term antitumor immunity still remains be an extreme challenge. Herein, the design advanced redox-responsive nanomedicine formulation based on phosphorus dendrimer-copper(II) complexes (1G3 -Cu)- toyocamycin (Toy)-loaded polymeric nanoparticles (GCT NPs) coated with cancer cell membranes (CM) are reported. The designed GCT@CM NPs a size 210 nm stable under physiological conditions but rapidly dissociated in reductive tumor microenvironment deplete glutathione release drugs. co-loading 1G3 -Cu Toy within causes significant apoptosis immunogenic death through -Cu-induced mitochondrial dysfunction Toy-mediated amplification endoplasmic reticulum stress, respectively, thus effectively suppressing growth, promoting dendritic maturation, increasing tumor-infiltrating cytotoxic T lymphocytes. Likewise, CM loaded render homotypic targeting T1 -weighted magnetic resonance imaging tumors, respectively. With assistance programmed ligand 1 antibody, NP-mediated chemotherapy can significantly potentiate immunotherapy for effective inhibition recurrence metastasis. developed hold great potential chemotherapy-potentiated different types mechanisms or synergies.

Язык: Английский

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Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier

ACS Nano, Год журнала: 2024, Номер 18(3), С. 1820 - 1845

Опубликована: Янв. 9, 2024

The blood–brain barrier (BBB) is a specialized semipermeable structure that highly regulates exchanges between the central nervous system parenchyma and blood vessels. Thus, BBB also prevents passage of various forms therapeutic agents, nanocarriers, their cargos. Recently, many multidisciplinary studies focus on developing cargo-loaded nanoparticles (NPs) to overcome these challenges, which are emerging as safe effective vehicles in neurotheranostics. In this Review, first we introduce anatomical physiological functions BBB. Second, present endogenous exogenous transport mechanisms by NPs cross We report nanomaterials, carriers, cargos, with detailed uptake permeability characteristics. Third, describe effect regulating size, shape, charge, surface ligands affect permeability, can be exploited enhance promote classify typical functionalized nanomaterials developed for crossing. Fourth, provide comprehensive review recent progress functional polymeric applications multimodal bioimaging, therapeutics, drug delivery. Finally, conclude discussing existing directions, future perspectives employing

Язык: Английский

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Advanced strategies to evade the mononuclear phagocyte system clearance of nanomaterials

Exploration, Год журнала: 2023, Номер 3(1)

Опубликована: Янв. 5, 2023

Nanomaterials are promising carriers to improve the bioavailability and therapeutic efficiency of drugs by providing preferential drug accumulation at their sites action, but delivery efficacy is severely limited a series biological barriers, especially mononuclear phagocytic system (MPS)-the first major barrier encountered systemically administered nanomaterials. Herein, current strategies for evading MPS clearance nanomaterials summarized. First, engineering methods including surface modification, cell hitchhiking, physiological environment modulation reduce explored. Second, disabling blockade, suppression macrophage phagocytosis, macrophages depletion examined. Last, challenges opportunities in this field further discussed.

Язык: Английский

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Biomimetic Macrophage Membrane-Camouflaged Nanoparticles Induce Ferroptosis by Promoting Mitochondrial Damage in Glioblastoma

ACS Nano, Год журнала: 2023, Номер 17(23), С. 23746 - 23760

Опубликована: Ноя. 22, 2023

The increasing understanding of ferroptosis has indicated its role and therapeutic potential in cancer; however, this knowledge yet to be translated into effective therapies. Glioblastoma (GBM) patients face a bleak prognosis encounter challenges due the limited treatment options available. In study, we conducted genome-wide CRISPR–Cas9 screening presence inducer (RSL3) identify key driver genes involved ferroptosis. We identified ALOX15, lipoxygenase (LOX), as an essential Small activating RNA (saRNA) was used mediate expression ALOX15 promoted GBM cells. then coated saALOX15-loaded mesoporous polydopamine (MPDA) with Angiopep-2-modified macrophage membranes (MMs) reduce clearance by mononuclear phagocyte system (MPS) increase ability complex cross blood–brain barrier (BBB) during specific targeted therapy orthotopic GBM. These generated hybrid nanoparticles (NPs) induced mediating mitochondrial dysfunction rendering morphology abnormal. vivo, modified MM enabled NPs target cells, exert marked inhibitory effect on progression, promote radiosensitivity. Our results reveal promising suggest biomimetic strategy that depends biological properties MMs enhance vivo performance for treating

Язык: Английский

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Augmenting Immunotherapy via Bioinspired MOF‐Based ROS Homeostasis Disruptor with Nanozyme‐Cascade Reaction

Advanced Materials, Год журнала: 2023, Номер 35(49)

Опубликована: Сен. 10, 2023

Despite its remarkable clinical breakthroughs, immune checkpoint blockade (ICB) therapy remains limited by the insufficient response in "cold" tumor. Nanozyme-based antitumor catalysis is associated with precise activation tumor microenvironment (TME). In this study, a cascade-augmented nanoimmunomodulator (CMZM) multienzyme-like activities, which includes superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and glutathione oxidase (GSHOx), that dissociates under an acidic abundant GSH TME, proposed for multimodal imaging-guided chemodynamic (CDT)/photodynamic (PDT) enhanced immunotherapy. Vigorous activities can not only produce O2 to alleviate hypoxia promote polarization of M2 M1 macrophages, but also generate ROS (•OH 1 ) deplete TME expose necrotic cell fragments reverse immunosuppressive eliciting maturation dendritic cells infiltration cytotoxic T lymphocytes (CTLs) tumors. Therefore, inhibitory effects on both primary distant tumors are achieved through synergy α-PD-L1 blocking antibody. This cascade multienzyme-based nanoplatform provides smart strategy highly efficient ICB immunotherapy against revising TME.

Язык: Английский

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Nano-drug delivery system targeting tumor microenvironment: A prospective strategy for melanoma treatment

Cancer Letters, Год журнала: 2023, Номер 574, С. 216397 - 216397

Опубликована: Сен. 18, 2023

Язык: Английский

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Recent advances in biomimetic nanodelivery systems: New brain-targeting strategies

Journal of Controlled Release, Год журнала: 2023, Номер 358, С. 439 - 464

Опубликована: Май 13, 2023

Язык: Английский

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Multifunctional Calcium–Manganese Nanomodulator Provides Antitumor Treatment and Improved Immunotherapy via Reprogramming of the Tumor Microenvironment

ACS Nano, Год журнала: 2023, Номер 17(16), С. 15449 - 15465

Опубликована: Авг. 2, 2023

Ions play a vital role in regulating various biological processes, including metabolic and immune homeostasis, which involves tumorigenesis therapy. Thus, the perturbation of ion homeostasis can induce tumor cell death evoke responses, providing specific antitumor effects. However, strategies that exploit effects multiion are rare. We herein prepared pH-responsive nanomodulator by coloading curcumin (CU, Ca

Язык: Английский

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