Materials & Design,
Год журнала:
2023,
Номер
237, С. 112620 - 112620
Опубликована: Дек. 30, 2023
Chronic
diabetic
wounds
seriously
threaten
human
health
due
to
their
intractable
nature
in
a
complex
pathological
microenvironment
that
contains
oxidative
stress,
persistent
inflammatory
status,
hypoxia
and
bacterial
infections,
of
which
damage
contributing
the
most.
Applied
materials
can
mimic
natural
intracellular
antioxidant
defense
system
are
perceived
have
huge
therapeutic
potential.
Herein,
we
present
novel
strategy
prepare
versatile
nanocomposite
hydrogel
by
incorporating
nanoenzyme
(manganese
dioxide
(MnO2))
nonenzymatic
components
(polydopamine
(PDA))
dynamic
network
composed
thioctic
acid
tannic
(TA).
The
prepared
exhibited
outstanding
adhesive
injectable
properties,
making
it
adapt
perfectly
with
different
shapes
depths.
More
importantly,
encapsulation
PDA@MnO2
nanoparticles
(NPs)
conferred
superior
performance
effectively
scavenge
multiple
types
reactive
nitrogen
oxygen
species
(RNOS)
reduce
response
regulating
macrophage
polarization.
Meanwhile,
showed
high-performance
catalyzing
ability
transfer
hydrogen
peroxide
(H2O2)
into
(O2),
could
further
alleviate
hypoxic
wound
environment.
Moreover,
excellent
near-infrared
(NIR)
photothermal
antibacterial
effect.
Collectively,
our
findings
indicate
synthesized
shows
potential
for
use
clinical
setting
treat
wounds.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(36)
Опубликована: Апрель 27, 2024
Abstract
An
asymmetrical
wound
dressing
functions
akin
to
human
skin
by
serving
as
a
protective
barrier
between
and
its
immediate
environment.
However,
significant
challenges
persist
concerning
the
robust
adhesion
properties
of
hydrogels,
particularly
when
applied
in
emergency
hemostasis
healing
contexts.
Herein,
study
has
successfully
synthesized
hydrogel
patches
with
Janus
asymmetric‐adhesion,
denoted
HGO‐C,
exclusively
comprised
natural
polymers.
This
achievement
is
realized
through
assembly
adhesive
(HGO)
non‐adhesive
(CGC),
thereby
amalgamating
their
distinct
functionalities.
The
component
served
physical
shield
safeguarding
against
contamination,
while
hydrogel,
contacted
surface,
firmly
adhered
it,
swiftly
arresting
bleeding
facilitating
healing.
Cytocompatibility
tests,
hemolysis
antibacterial
assays,
coagulation
assays
demonstrated
excellent
biocompatibility,
antibacterial,
hemostatic
HGO‐C.
Finally,
vivo
experiments,
including
liver
hemorrhage
assay
assay,
unequivocally
showed
rapid
enhanced
capabilities
Consequently,
these
distinctive
patches,
derived
from
polymers
characterized
asymmetric
properties,
may
have
great
potential
for
real‐life
usage
clinical
patients.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(22)
Опубликована: Май 9, 2024
Hydrogels
have
emerged
as
promising
candidates
for
biomedical
applications,
especially
in
the
field
of
antibacterial
therapeutics,
due
to
their
unique
structural
properties,
highly
tunable
physicochemical
and
excellent
biocompatibility.
The
integration
stimuli-responsive
functions
into
hydrogels
holds
potential
enhance
properties
therapeutic
efficacy,
dynamically
responding
different
external
or
internal
stimuli,
such
pH,
temperature,
enzymes,
light.
Therefore,
this
review
describes
applications
hydrogel
dressings
responsive
stimuli
therapy.
collaborative
interaction
between
materials
is
discussed.
This
synergistic
approach,
contrast
conventional
materials,
not
only
amplifies
effect
but
also
alleviates
adverse
side
effects
diminishes
incidence
multiple
infections
drug
resistance.
provides
a
comprehensive
overview
current
challenges
outlines
future
research
directions
hydrogels.
It
underscores
imperative
ongoing
interdisciplinary
aimed
at
unraveling
mechanisms
wound
healing.
understanding
crucial
optimizing
design
implementation
Ultimately,
aims
offer
scientific
guidance
development
practical
clinical
application
dressings.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(21)
Опубликована: Янв. 28, 2024
Abstract
Abdominal
and
intrauterine
adhesions
are
common
postoperative
problems
that
can
cause
serious
complications.
Current
adhesives
usually
double
sided
suffer
from
poor
wet
adhesion,
nondegradability,
monofunctionality,
which
limits
their
application
in
preventing
adhesions.
Herein,
a
bioinspired
microstructured
Janus
bioadhesive,
named
OD/GM@PG,
with
adhesive
inner
layer
an
antiadhesive
outer
is
prepared
by
combining
electrostatic
spun
materials.
By
using
both
capillary
suction
catechol‐based
strategy,
the
strength
interfacial
toughness
of
bioadhesive
reach
98
kPa
325
J
m
−2
,
respectively,
much
higher
than
those
commercial
fibrin
glues
cyanoacrylate
glues.
The
acts
as
physical
barrier
friction‐reducing
effects.
Additionally,
demonstrates
biodegradable,
hemostatic,
antioxidative,
anti‐inflammatory,
prohealing
properties.
In
vivo
results
show
asymmetric
adhesion
effect
effectively
abdominal
Notably,
tandem
mass
tags‐labeled
quantitative
proteomics
analysis
demonstrate
expression
inflammatory
response‐associated
proteins
(S100A8,
S100A9)
associated
adhesion;
significantly
downregulates
this
expression.
Therefore,
OD/GM@PG
promising
candidate
for
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Hemorrhage
continues
to
pose
a
significant
challenge
in
various
medical
contexts,
underscoring
the
need
for
advanced
hemostatic
materials.
Hemostatic
hydrogels
have
gained
recognition
as
innovative
tools
addressing
uncontrollable
bleeding,
attributed
their
distinctive
features
including
biological
compatibility,
tunable
mechanical
properties,
and
exceptional
performance.
This
review
provides
comprehensive
overview
of
that
offer
rapid
effective
bleeding
control.
Particularly,
this
focuses
on
hydrogel
design
associated
mechanisms.
Additionally,
recent
advancements
application
these
materials
are
discussed
detail,
especially
clinical
trials.
Finally,
challenges
potential
analyzed
assessed.
seeks
emphasize
role
biomedical
applications
hemorrhage
control
provide
perspectives
innovation
clinically
applicable
Advanced Materials,
Год журнала:
2023,
Номер
35(49)
Опубликована: Июнь 3, 2023
Bioadhesives
with
antimicrobial
properties
enable
easier
and
safer
treatment
of
wounds
as
compared
to
the
traditional
methods
such
suturing
stapling.
Composed
natural
or
synthetic
polymers,
these
bioadhesives
seal
facilitate
healing
while
preventing
infections
through
activity
locally
released
drugs,
nanocomponents,
inherently
polers.
Although
many
different
materials
strategies
are
employed
develop
bioadhesives,
design
biomaterials
necessitates
a
prudent
approach
achieving
all
required
including
optimal
adhesive
cohesive
properties,
biocompatibility,
can
be
challenging.
Designing
tunable
physical,
chemical,
biological
will
shed
light
on
path
for
future
advancement
properties.
In
this
review,
requirements
commonly
used
developing
discussed.
particular,
their
synthesis
experimental
clinical
applications
variety
organs
reviewed.
Advances
in
pave
way
better
management
increase
positive
outcomes.
