Chemical Society Reviews, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
This tutorial review presents the development of advanced immunomodulatory hydrogels strategically designed to address chronic inflammation through their intrinsic properties.
Язык: Английский
Journal of Hematology & Oncology, Год журнала: 2023, Номер 16(1)
Опубликована: Ноя. 30, 2023
Inflammation is a fundamental defensive response to harmful stimuli, but the overactivation of inflammatory responses associated with most human diseases. Reactive oxygen species (ROS) are class chemicals that generated after incomplete reduction molecular oxygen. At moderate levels, ROS function as critical signaling molecules in modulation various physiological functions, including responses. However, at excessive exert toxic effects and directly oxidize biological macromolecules, such proteins, nucleic acids lipids, further exacerbating development causing Therefore, designing manufacturing biomaterials scavenge has emerged an important approach for restoring homeostasis, limiting protecting host against damage. This review systematically outlines dynamic balance production clearance under conditions. We focus on mechanisms by which regulate cell proteins how these affect inflammation. Furthermore, we discuss use potential currently available-biomaterials ROS, agents were engineered reduce levels blocking generation, chemically reacting or catalytically accelerating clearance, treatment Finally, evaluate challenges prospects controlled material design scavenging biomaterials.
Язык: Английский
Процитировано
218
Advanced Healthcare Materials, Год журнала: 2023, Номер 13(1)
Опубликована: Сен. 13, 2023
Abstract The healing of diabetic wounds is hindered by various factors, including bacterial infection, macrophage dysfunction, excess proinflammatory cytokines, high levels reactive oxygen species, and sustained hypoxia. These factors collectively impede cellular behaviors the process. Consequently, this review presents intelligent hydrogels equipped with multifunctional capacities, which enable them to dynamically respond microenvironment accelerate wound in ways, stimuli ‐responsiveness, injectable self‐healing, shape ‐memory, conductive real‐time monitoring properties. relationship between multiple functions also discussed. Based on wounds, antibacterial, anti‐inflammatory, immunomodulatory, antioxidant, pro‐angiogenic strategies are combined hydrogels. application repair systematically discussed, aiming provide guidelines for fabricating exploring role therapeutic processes.
Язык: Английский
Процитировано
124
Advanced Functional Materials, Год журнала: 2023, Номер 33(10)
Опубликована: Янв. 1, 2023
Abstract Diabetic foot ulcer (DFU) is one of the most common complications diabetes, bringing physical and mental challenges for patients due to lack efficient curative therapy. Despite considerable advances in pharmacological surgical approaches, clinical trials DFU remain disappointing local overactive excessive inflammation. Immunomodulatory hydrogels has significant advantages overcome challenge DFUs Here, recent fabrication regenerative utilization functional altering immune microenvironment are comprehensively reviewed. The pathological features healing processes DFUs, followed by summarizing physicochemical properties essential design immunomodulation briefly introduced. Then, potential immuno‐therapeutic modalities emerging trends used treat via multitherapeutic approaches enhanced efficacy safety discussed. Taken together, linking structural their functions therapy with a particular focus on immunomodulatory stimuli, this review can promote further designing advanced resulting improved diabetic wound repair through translation into setting near future.
Язык: Английский
Процитировано
80
Chemical Engineering Journal, Год журнала: 2024, Номер 484, С. 149493 - 149493
Опубликована: Фев. 10, 2024
Язык: Английский
Процитировано
62
Chemical Engineering Journal, Год журнала: 2023, Номер 469, С. 143985 - 143985
Опубликована: Июнь 7, 2023
Язык: Английский
Процитировано
61
Materials Horizons, Год журнала: 2023, Номер 11(1), С. 37 - 101
Опубликована: Окт. 27, 2023
The unique network characteristics and stimuli responsiveness of supramolecular hydrogels have rendered them highly advantageous in the field wound dressings, showcasing unprecedented potential. However, there are few reports on a comprehensive review hydrogel dressings for repair hemostasis. This first introduces major cross-linking methods hydrogels, which includes hydrogen bonding, electrostatic interactions, hydrophobic host-guest metal ligand coordination some other interactions. Then, we advanced materials reported recent years then summarize basic principles each method. Next, classify structures before outlining their forming process propose potential future directions. Furthermore, also discuss raw materials, structural design principles, material used to achieve functions such as antibacterial function, tissue adhesion, substance delivery, anti-inflammatory antioxidant functions, cell behavior regulation, angiogenesis promotion, hemostasis innovative years. Finally, existing problems well development directions strategy, design, discussed. is proposed stimulate further exploration by researchers future.
Язык: Английский
Процитировано
57
ACS Nano, Год журнала: 2024, Номер 18(9), С. 7024 - 7036
Опубликована: Фев. 23, 2024
Chronic wounds frequently arise as a complication in diabetic patients, and their management remains significant clinical hurdle due to nonhealing nature featured by heightened oxidative stress impaired healing cells at the wound site. Herein, we present 2D copper antioxidant nanozyme induced phenolic ligand–metal charge transfer (LMCT) eliminate reactive oxygen species (ROS) facilitate of chronic wounds. We found that polyphenol ligands coordinated on Cu3(PO4)2 nanosheets led strong interface regulated valence states Cu. The obtained Cu exhibited efficient scavenging ability toward different protected human from damage. enhanced promoting re-epithelialization, collagen deposition, angiogenesis, immunoregulation. This work demonstrates LMCT-induced ROS nanointerface, providing an alternative strategy constructing metal-based nanozymes for treatment well other diseases.
Язык: Английский
Процитировано
46
ACS Nano, Год журнала: 2024, Номер 18(5), С. 4269 - 4286
Опубликована: Янв. 25, 2024
The repair of diabetic wounds remains challenging, primarily due to the high-glucose-derived immune inhibition which often leads excessive inflammatory response, impaired angiogenesis, and heightened susceptibility infection. However, means reduce immunosuppression regulate conversion M2 phenotype macrophages under a high-glucose microenvironment using advanced biomaterials for are not yet fully understood. Herein, we report two-dimensional carbide (MXene)-M2 macrophage exosome (Exo) nanohybrids (FM-Exo) promoting wound by overcoming inhibition. FM-Exo showed sustained release macrophage-derived exosomes (M2-Exo) up 7 days exhibited broad-spectrum antibacterial activity. In microenvironment, relative single Exo, could significantly induce optimized M2a/M2c polarization ratio activating PI3K/Akt signaling pathway, proliferation, migration fibroblasts, angiogenic ability endothelial cells. full-thickness model, effectively regulated status promoted their transition phenotype, thereby inhibiting inflammation, angiogenesis through VEGF secretion, improving proper collagen deposition. As result, healing process was accelerated, leading better outcome with reduced scarring. Therefore, this study introduced promising approach address developing bioactive nanomaterials in environment.
Язык: Английский
Процитировано
38
Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150756 - 150756
Опубликована: Март 26, 2024
Язык: Английский
Процитировано
28
Chemical Engineering Journal, Год журнала: 2024, Номер 496, С. 153803 - 153803
Опубликована: Июль 6, 2024
Язык: Английский
Процитировано
27