Chemical Society Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
This
tutorial
review
presents
the
development
of
advanced
immunomodulatory
hydrogels
strategically
designed
to
address
chronic
inflammation
through
their
intrinsic
properties.
Journal of Hematology & Oncology,
Год журнала:
2023,
Номер
16(1)
Опубликована: Ноя. 30, 2023
Inflammation
is
a
fundamental
defensive
response
to
harmful
stimuli,
but
the
overactivation
of
inflammatory
responses
associated
with
most
human
diseases.
Reactive
oxygen
species
(ROS)
are
class
chemicals
that
generated
after
incomplete
reduction
molecular
oxygen.
At
moderate
levels,
ROS
function
as
critical
signaling
molecules
in
modulation
various
physiological
functions,
including
responses.
However,
at
excessive
exert
toxic
effects
and
directly
oxidize
biological
macromolecules,
such
proteins,
nucleic
acids
lipids,
further
exacerbating
development
causing
Therefore,
designing
manufacturing
biomaterials
scavenge
has
emerged
an
important
approach
for
restoring
homeostasis,
limiting
protecting
host
against
damage.
This
review
systematically
outlines
dynamic
balance
production
clearance
under
conditions.
We
focus
on
mechanisms
by
which
regulate
cell
proteins
how
these
affect
inflammation.
Furthermore,
we
discuss
use
potential
currently
available-biomaterials
ROS,
agents
were
engineered
reduce
levels
blocking
generation,
chemically
reacting
or
catalytically
accelerating
clearance,
treatment
Finally,
evaluate
challenges
prospects
controlled
material
design
scavenging
biomaterials.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(1)
Опубликована: Сен. 13, 2023
Abstract
The
healing
of
diabetic
wounds
is
hindered
by
various
factors,
including
bacterial
infection,
macrophage
dysfunction,
excess
proinflammatory
cytokines,
high
levels
reactive
oxygen
species,
and
sustained
hypoxia.
These
factors
collectively
impede
cellular
behaviors
the
process.
Consequently,
this
review
presents
intelligent
hydrogels
equipped
with
multifunctional
capacities,
which
enable
them
to
dynamically
respond
microenvironment
accelerate
wound
in
ways,
stimuli
‐responsiveness,
injectable
self‐healing,
shape
‐memory,
conductive
real‐time
monitoring
properties.
relationship
between
multiple
functions
also
discussed.
Based
on
wounds,
antibacterial,
anti‐inflammatory,
immunomodulatory,
antioxidant,
pro‐angiogenic
strategies
are
combined
hydrogels.
application
repair
systematically
discussed,
aiming
provide
guidelines
for
fabricating
exploring
role
therapeutic
processes.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(10)
Опубликована: Янв. 1, 2023
Abstract
Diabetic
foot
ulcer
(DFU)
is
one
of
the
most
common
complications
diabetes,
bringing
physical
and
mental
challenges
for
patients
due
to
lack
efficient
curative
therapy.
Despite
considerable
advances
in
pharmacological
surgical
approaches,
clinical
trials
DFU
remain
disappointing
local
overactive
excessive
inflammation.
Immunomodulatory
hydrogels
has
significant
advantages
overcome
challenge
DFUs
Here,
recent
fabrication
regenerative
utilization
functional
altering
immune
microenvironment
are
comprehensively
reviewed.
The
pathological
features
healing
processes
DFUs,
followed
by
summarizing
physicochemical
properties
essential
design
immunomodulation
briefly
introduced.
Then,
potential
immuno‐therapeutic
modalities
emerging
trends
used
treat
via
multitherapeutic
approaches
enhanced
efficacy
safety
discussed.
Taken
together,
linking
structural
their
functions
therapy
with
a
particular
focus
on
immunomodulatory
stimuli,
this
review
can
promote
further
designing
advanced
resulting
improved
diabetic
wound
repair
through
translation
into
setting
near
future.
Materials Horizons,
Год журнала:
2023,
Номер
11(1), С. 37 - 101
Опубликована: Окт. 27, 2023
The
unique
network
characteristics
and
stimuli
responsiveness
of
supramolecular
hydrogels
have
rendered
them
highly
advantageous
in
the
field
wound
dressings,
showcasing
unprecedented
potential.
However,
there
are
few
reports
on
a
comprehensive
review
hydrogel
dressings
for
repair
hemostasis.
This
first
introduces
major
cross-linking
methods
hydrogels,
which
includes
hydrogen
bonding,
electrostatic
interactions,
hydrophobic
host-guest
metal
ligand
coordination
some
other
interactions.
Then,
we
advanced
materials
reported
recent
years
then
summarize
basic
principles
each
method.
Next,
classify
structures
before
outlining
their
forming
process
propose
potential
future
directions.
Furthermore,
also
discuss
raw
materials,
structural
design
principles,
material
used
to
achieve
functions
such
as
antibacterial
function,
tissue
adhesion,
substance
delivery,
anti-inflammatory
antioxidant
functions,
cell
behavior
regulation,
angiogenesis
promotion,
hemostasis
innovative
years.
Finally,
existing
problems
well
development
directions
strategy,
design,
discussed.
is
proposed
stimulate
further
exploration
by
researchers
future.
ACS Nano,
Год журнала:
2024,
Номер
18(9), С. 7024 - 7036
Опубликована: Фев. 23, 2024
Chronic
wounds
frequently
arise
as
a
complication
in
diabetic
patients,
and
their
management
remains
significant
clinical
hurdle
due
to
nonhealing
nature
featured
by
heightened
oxidative
stress
impaired
healing
cells
at
the
wound
site.
Herein,
we
present
2D
copper
antioxidant
nanozyme
induced
phenolic
ligand–metal
charge
transfer
(LMCT)
eliminate
reactive
oxygen
species
(ROS)
facilitate
of
chronic
wounds.
We
found
that
polyphenol
ligands
coordinated
on
Cu3(PO4)2
nanosheets
led
strong
interface
regulated
valence
states
Cu.
The
obtained
Cu
exhibited
efficient
scavenging
ability
toward
different
protected
human
from
damage.
enhanced
promoting
re-epithelialization,
collagen
deposition,
angiogenesis,
immunoregulation.
This
work
demonstrates
LMCT-induced
ROS
nanointerface,
providing
an
alternative
strategy
constructing
metal-based
nanozymes
for
treatment
well
other
diseases.
ACS Nano,
Год журнала:
2024,
Номер
18(5), С. 4269 - 4286
Опубликована: Янв. 25, 2024
The
repair
of
diabetic
wounds
remains
challenging,
primarily
due
to
the
high-glucose-derived
immune
inhibition
which
often
leads
excessive
inflammatory
response,
impaired
angiogenesis,
and
heightened
susceptibility
infection.
However,
means
reduce
immunosuppression
regulate
conversion
M2
phenotype
macrophages
under
a
high-glucose
microenvironment
using
advanced
biomaterials
for
are
not
yet
fully
understood.
Herein,
we
report
two-dimensional
carbide
(MXene)-M2
macrophage
exosome
(Exo)
nanohybrids
(FM-Exo)
promoting
wound
by
overcoming
inhibition.
FM-Exo
showed
sustained
release
macrophage-derived
exosomes
(M2-Exo)
up
7
days
exhibited
broad-spectrum
antibacterial
activity.
In
microenvironment,
relative
single
Exo,
could
significantly
induce
optimized
M2a/M2c
polarization
ratio
activating
PI3K/Akt
signaling
pathway,
proliferation,
migration
fibroblasts,
angiogenic
ability
endothelial
cells.
full-thickness
model,
effectively
regulated
status
promoted
their
transition
phenotype,
thereby
inhibiting
inflammation,
angiogenesis
through
VEGF
secretion,
improving
proper
collagen
deposition.
As
result,
healing
process
was
accelerated,
leading
better
outcome
with
reduced
scarring.
Therefore,
this
study
introduced
promising
approach
address
developing
bioactive
nanomaterials
in
environment.