Gels,
Год журнала:
2024,
Номер
10(8), С. 544 - 544
Опубликована: Авг. 22, 2024
Osteonecrosis
of
the
femoral
head
(ONFH)
is
a
vascular
disease
unknown
etiology
and
can
be
categorized
mainly
into
two
types:
non-traumatic
traumatic
ONFH.
Thus,
understanding
osteogenic–angiogenic
coupling
prime
importance
in
finding
solution
for
treatment
Hydrogels
are
biomaterials
that
similar
to
extracellular
matrix
(ECM).
As
they
able
mimic
real
tissue,
meet
one
most
important
rules
tissue
engineering.
In
ONFH
studies,
hydrogels
have
recently
become
popular
because
their
ability
retain
water
adjustable
properties,
injectability,
mimicry
natural
ECM.
Because
bone
regeneration
graft
materials
very
broad
areas
research
complex
situation
including
systems,
there
no
settled
strategy
worldwide,
this
review
paper,
we
followed
top-down
approach
by
reviewing
(1)
grafting,
(2)
hydrogels,
(3)
(4)
hydrogel
use
with
studies
literature
which
show
promising
results
limited
clinical
studies.
The
aim
paper
provide
reader
general
information
on
every
aspect
focus
used
Theranostics,
Год журнала:
2024,
Номер
14(5), С. 2099 - 2126
Опубликована: Янв. 1, 2024
Exosomes,
which
are
small
vesicles
enclosed
by
a
lipid
bilayer
and
released
many
cell
types,
widely
dispersed
have
garnered
increased
attention
in
the
field
of
regenerative
medicine
due
to
their
ability
serve
as
indicators
diseases
agents
with
therapeutic
potential.
Exosomes
play
crucial
role
mediating
intercellular
communication
through
transfer
biomolecules,
including
proteins,
lipids,
RNA,
other
molecular
constituents,
between
cells.
The
targeted
transport
proteins
nucleic
acids
specific
cells
has
potential
enhance
or
impair
biological
functions.
applications,
they
can
be
used
alone
combination
approaches.
examination
unique
attributes
functions
these
factors
emerged
prominent
study
realm
biomedical
research.
This
manuscript
summarizes
origins
properties
exosomes,
structural,
biological,
physical,
chemical
aspects.
paper
offers
complete
recent
progress
tissue
repair
medicine,
emphasizing
possible
implications
methods
forthcoming
regeneration
attempts.
Biomacromolecules,
Год журнала:
2024,
Номер
25(6), С. 3217 - 3248
Опубликована: Янв. 18, 2024
Hydrogel,
as
a
unique
scaffold
material,
features
three-dimensional
network
system
that
provides
conducive
conditions
for
the
growth
of
cells
and
tissues
in
bone
tissue
engineering
(BTE).
In
recent
years,
it
has
been
discovered
metal
ion-containing
hybridized
hydrogels,
synthesized
with
particles
foundation,
exhibit
excellent
physicochemical
properties,
osteoinductivity,
osteogenic
potential.
They
offer
wide
range
research
prospects
field
BTE.
This
review
an
overview
current
state
advancements
concerning
hydrogels
Within
materials
science,
covers
topics
such
binding
mechanisms
ions
within
hydrogel
networks,
types
fabrication
methods
various
influence
on
properties
hydrogels.
context
BTE,
delves
into
ions,
applications
relevant
experimental
studies
vitro
vivo.
Furthermore,
future
improvements
repair
can
be
anticipated
through
bionics,
exploring
interactions
between
development
wider
types.
Chemical Engineering Journal,
Год журнала:
2024,
Номер
488, С. 150631 - 150631
Опубликована: Март 26, 2024
The
skeletal
system
is
essential
for
preserving
body
structure
and
facilitating
mobility;
however,
bone
diseases
frequently
result
in
significant
disabilities,
necessitating
the
investigation
into
biomaterials
restoration.
Nevertheless,
these
may
elicit
immune
reactions
that
obstruct
healing
process.
Macrophages
assume
a
pivotal
role
modulating
inflammation
sustaining
homeostasis
regeneration.
A
comprehensive
understanding
of
molecular
interactions
between
macrophages
imperative
development
sophisticated
designed
to
regulate
environment
promote
remodeling.
This
review
delves
generation,
polarization,
interaction
with
principal
cell
types
implicated
osteogenesis,
detailing
mechanisms
by
which
influence
repair
their
response
biomaterials.
Additionally,
it
discusses
strategies
precise
modulation
macrophage
functionality
via
intelligent
mechanisms,
outlines
challenges
constraints
designing
integrate
functions.
By
elucidating
challenges,
lays
groundwork
creation
advanced
endowed
smart
immunomodulatory
capabilities,
heralding
novel
approaches
treatment
defects
advancement
regeneration
therapies.
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Май 2, 2024
Abstract
The
escalating
threat
of
bone-related
diseases
poses
a
significant
challenge
to
human
health.
Mesenchymal
stem
cell
(MSC)-derived
extracellular
vesicles
(MSC-EVs),
as
inherent
cell-secreted
natural
products,
have
emerged
promising
treatments
for
diseases.
Leveraging
outstanding
features
such
high
biocompatibility,
low
immunogenicity,
superior
biological
barrier
penetration,
and
extended
circulating
half-life,
MSC-EVs
serve
potent
carriers
microRNAs
(miRNAs),
long
no-code
RNAs
(lncRNAs),
other
biomolecules.
These
cargo
molecules
play
pivotal
roles
in
orchestrating
bone
metabolism
vascularity
through
diverse
mechanisms,
thereby
contributing
the
amelioration
Additionally,
engineering
modifications
enhance
bone-targeting
ability
MSC-EVs,
mitigating
systemic
side
effects
bolstering
their
clinical
translational
potential.
This
review
comprehensively
explores
mechanisms
which
regulate
disease
progression.
It
delves
into
therapeutic
potential
adept
drug
carriers,
augmented
by
engineered
modification
strategies
tailored
osteoarthritis
(OA),
rheumatoid
arthritis
(RA),
osteoporosis,
osteosarcoma.
In
conclusion,
exceptional
promise
exhibited
positions
them
an
excellent
solution
with
considerable
applications
orthopedics.
Abstract
With
the
aging
and
obesity
era,
increasing
incidence
of
diabetes
diabetic
complications,
especially
non‐healing
wounds,
imposes
a
serious
economic
burden
on
both
patients
society.
The
complex
microenvironments,
including
hyperglycemia,
bacterial
infection,
ischemia,
nerve
damage,
lead
to
prolonged
inflammation
proliferation
phase
wounds.
Mesenchymal
stem
cell‐derived
small
extracellular
vesicles
(MSC‐sEVs),
which
contain
rich
variety
therapeutic
molecules,
have
been
chased
for
decades
because
their
potential
roles
in
cellular
communication,
tissue
regeneration,
drug
delivery.
As
powerful
tools
controlled‐sustained
release
sEVs,
biocompatible
hydrogels
applied
wide
range
biomedical
applications.
Herein,
we
first
summarize
pathological
features
such
as
angiopathy,
neuropathy,
immune
cell
dysfunction.
Then,
discuss
biological
properties,
performance,
stability
pure
MSC‐sEVs.
After
that,
components,
application
patterns,
responsiveness
hydrogels.
Next,
loading
avenues
MSC‐sEVs
into
hydrogel,
behaviors
sEVs
from
hydrogels,
influence
crosslinking
method
hydrogel‐sEV
composites.
Finally,
provide
an
overview
current
applications
loaded
with
novel
cell‐free
engineering
system
managing
wounds
propose
critical
unsolved
issues.
This
review
is
expected
meaningful
guidance
developing
wound
management.
Journal of Tissue Engineering,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 1, 2025
Osteonecrosis
of
the
femoral
head
(ONFH)
is
a
prevalent
orthopedic
disorder
characterized
primarily
by
compromised
blood
supply.
This
vascular
deficit
results
in
cell
apoptosis,
trabecular
bone
loss,
and
structural
collapse
at
late
stage,
significantly
impairing
joint
function.
While
MRI
highly
effective
tool
for
diagnosing
ONFH
its
early
stages,
challenges
remain
due
to
limited
availability
high
cost
MRI,
as
well
absence
routine
screening
asymptomatic
patients.
.
In
addition,
current
therapeutic
strategies
predominantly
only
relieve
symptoms
while
disease-modifying
drugs
are
still
under
investigation/development.
Considering
that
supply
plays
key
role
pathology
ONFH,
angiogenic
therapies
have
been
put
forward
promising
treatment
options.
Emerging
bioengineering
interventions
targeting
angiogenesis
hold
potential
treatment.
this
review,
we
introduce
advances
research
into
summarize
novel
angiogenesis.
review
sheds
light
upon
new
directions
future
ONFH.
Periodontology 2000,
Год журнала:
2023,
Номер
94(1), С. 213 - 230
Опубликована: Окт. 12, 2023
The
use
of
biomaterials
in
regenerative
medicine
has
expanded
to
treat
various
disorders
caused
by
trauma
or
disease
orthopedics
and
dentistry.
However,
the
treatment
large
complex
bone
defects
presents
a
challenge,
leading
pressing
need
for
optimized
repair.
Recent
advances
chemical
sciences
have
enabled
incorporation
therapeutic
ions
into
grafts
enhance
their
performance.
These
ions,
such
as
strontium
(for
regeneration/osteoporosis),
copper
angiogenesis),
boron
growth),
iron
chemotaxis),
cobalt
B12
synthesis),
lithium
osteogenesis/cementogenesis),
silver
antibacterial
resistance),
magnesium
cartilage
regeneration),
among
others
(e.g.,
zinc,
sodium,
silica),
been
studied
extensively.
This
review
aims
provide
comprehensive
overview
current
knowledge
recent
developments
ion
periodontal
tissue
It
also
discusses
recently
developed
from
basic
design
clinical
application
perspective.
Additionally,
highlights
importance
precise
introduction
address
existing
limitations
challenges
combination
therapies.
Future
prospects
opportunities
development
optimization
engineering
are
emphasized.
