Biomacromolecules,
Год журнала:
2024,
Номер
25(7), С. 4329 - 4343
Опубликована: Июнь 4, 2024
The
development
of
nanotherapy
targeting
mitochondria
to
alleviate
oxidative
stress
is
a
critical
therapeutic
strategy
for
vascular
calcification
(VC)
in
diabetes.
In
this
study,
we
engineered
mitochondria-targeted
nanodrugs
(T4O@TPP/PEG–PLGA)
utilizing
terpinen-4-ol
(T4O)
as
natural
antioxidant
and
mitochondrial
protector,
PEG–PLGA
the
nanocarrier,
triphenylphosphine
(TPP)
ligand.
vitro
assessments
demonstrated
enhanced
cellular
uptake
T4O@TPP/PEG–PLGA,
with
effective
targeting.
This
nanodrug
successfully
reduced
induced
by
high
glucose
levels
smooth
muscle
cells.
vivo
studies
showed
prolonged
retention
nanomaterials
thoracic
aorta
up
24
h.
Importantly,
experiments
diabetic
VC
models
underscored
potent
properties
evidenced
its
ability
mitigate
restore
morphology.
These
results
suggest
that
these
could
be
promising
managing
VC.
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
508, С. 215773 - 215773
Опубликована: Март 14, 2024
Phototherapy,
using
light
as
a
therapeutic
modality,
has
been
widely
applied
in
treating
various
diseases,
especially
cancer.
This
approach
is
valued
for
its
non-invasive
nature
and
minimal
risk
of
drug
resistance.
However,
phototherapy
faces
challenges
such
the
undesired
delivery
phototherapeutic
agents,
potential
phototoxicity,
limited
penetration
into
tissues.
Lanthanide-doped
nanoparticles
offer
attractive
opportunities
to
improve
efficacy
photodynamic
therapy.
These
are
distinguished
by
their
unique
optical
properties,
excellent
photostability
against
blinking
bleaching
effects,
large
Stokes
or
anti-Stokes
shifts,
sharp
emission
peaks,
long
luminescence
lifetimes.
In
addition,
lanthanide-doped
can
be
excited
near-infrared
(NIR)
X-rays,
enabling
deep-tissue
penetration.
Beyond
use
photosensitizers,
nanoparticle
surfaces
easily
modified
with
targeting
ligands,
chemical
drugs,
functional
molecules
enhance
effectiveness
enable
combination
this
review,
we
organize
lanthanide-based
tumor
six
main
domains:
therapy,
photothermal
X-ray-based
light-controlled
photoimmunotherapy,
other
innovative
treatments
that
regulated
light.
We
introduce
basic
principles
characteristics
lanthanide
nanoparticles.
Following
this,
summarize
latest
advances
utilizing
phototherapy,
focusing
on
design
principles,
mechanisms
action,
cancer
treatment.
To
conclude,
address
existing
explore
future
within
area
research.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(17)
Опубликована: Янв. 3, 2024
Abstract
Hypoxia,
as
a
distinctive
feature
of
tumors,
is
closely
related
to
tumor
recurrence,
metastasis,
and
treatment
resistance.
Metal–organic
framework
(MOF)
exhibits
an
increasing
number
advantages
in
cancer
therapy
owing
its
porous
structure,
large
specific
surface
area,
tunable
function.
The
MOF
nanocomposites
constructed
by
adjusting
components
can
effectively
overcome
hypoxia
significantly
enhance
the
anti‐tumor
effect.
In
this
review,
hypoxic
characteristics
tumors
current
strategies
for
constructing
that
are
summarized,
including
delivering
O
2
or
endogenously
generating
elevate
intra‐tumor
content;
inhibiting
HIF‐1
induced
products
alleviate
hypoxia;
reducing
cellular
aerobic
respiration
decrease
consumption,
exacerbating
improve
efficacy
hypoxia‐activated
pre‐drugs.
At
same
time,
applications
applied
different
therapeutic
methods
at
present
stage
described,
finally,
challenges
opportunities
further
development
discussed.
Abstract
Immunotherapy
represents
a
widely
employed
modality
in
clinical
oncology,
leveraging
the
activation
of
human
immune
system
to
target
and
eradicate
cancer
cells
tumor
tissues
via
endogenous
mechanisms.
However,
its
efficacy
remains
constrained
by
inadequate
responses
within
“cold”
microenvironment
(TME).
In
this
study,
multifunctional
nanoscale
pyroptosis
inducer
with
cascade
enzymatic
activity
(IMZF),
comprising
superoxide
dismutase
(SOD),
catalase
(CAT),
peroxidase
(POD),
glutathione
oxidase
(GSHO
x
),
is
dissociated
acidic
glutathione‐rich
TME.
The
vigorous
not
only
generates
oxygen
(O
2
)
alleviate
hypoxia
promote
M2
M1
macrophage
polarization
but
also
yields
reactive
species
(ROS)
depletes
(GSH)
Functioning
as
an
immunogenic
cell
death
(ICD)
activator
inducer,
IMZF
synergistically
triggers
dendritic
maturation
inflammatory
lymphocyte
infiltration
ICD‐associated
pyroptosis,
thereby
reversing
suppression
TMEs.
Consequently,
it
exerts
inhibitory
effects
on
both
primary
distal
tumors.
This
platform‐based
offers
intelligent
strategy
for
effectively
overcoming
tumors,
providing
promising
avenue
advanced
immunotherapeutic
interventions.
Chemical Communications,
Год журнала:
2024,
Номер
60(93), С. 13641 - 13652
Опубликована: Янв. 1, 2024
Hypoxia
limits
the
phototherapeutic
efficacy
of
porphyrin-based
nMOFs;
loading
with
hypoxia-activated
drug
TPZ
enhances
combined
PDT
and
chemotherapy
effects.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 18, 2025
Photodynamic
therapy
(PDT)
has
gained
significant
attention
due
to
its
non-invasive
nature,
low
cost,
and
ease
of
operation.
Nanoscale
metal-organic
frameworks
(nMOFs)
incorporating
porphyrins,
chlorins,
bacteriochlorins
have
emerged
as
one
the
most
prominent
photoactive
materials
for
tumor
PDT.
These
nMOFs
could
enhance
water
solubility,
stability
loading
efficiency
photosensitizers
(PSs).
Their
highly
ordered
porous
structure
facilitates
O2
diffusion
enhances
generation
1O2
from
hydrophobic
bacteriochlorins,
thereby
improving
their
efficacy
phototherapy.
This
review
provides
insights
into
PDT
effects
derived
bacteriochlorins.
It
overviews
design
strategies,
types
reactive
oxygen
species
(ROS),
ROS
efficiency,
unique
biological
processes
involved
in
inhibiting
cell
proliferation,
focusing
on
mechanism
by
which
molecular
leads
enhanced
photochemical
properties.
Finally,
highlights
new
possibilities
offered
bacteriochlorins-based
PDT,
emphasizing
how
optimized
can
further
improve
bioapplication
porphyrin
derivatives
represented
PSs.
With
ongoing
research
technological
advancements,
we
anticipate
that
this
will
garner
increased
scientific
researchers
toward
porphyrin-based
nMOFs,
elevating
potential
a
approach
treatment
malignant
tumors.
