Lanthanide-based nanoparticles for cancer phototherapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 508, P. 215773 - 215773

Published: March 14, 2024

Phototherapy, using light as a therapeutic modality, has been widely applied in treating various diseases, especially cancer. This approach is valued for its non-invasive nature and minimal risk of drug resistance. However, phototherapy faces challenges such the undesired delivery phototherapeutic agents, potential phototoxicity, limited penetration into tissues. Lanthanide-doped nanoparticles offer attractive opportunities to improve efficacy photodynamic therapy. These are distinguished by their unique optical properties, excellent photostability against blinking bleaching effects, large Stokes or anti-Stokes shifts, sharp emission peaks, long luminescence lifetimes. In addition, lanthanide-doped can be excited near-infrared (NIR) X-rays, enabling deep-tissue penetration. Beyond use photosensitizers, nanoparticle surfaces easily modified with targeting ligands, chemical drugs, functional molecules enhance effectiveness enable combination this review, we organize lanthanide-based tumor six main domains: therapy, photothermal X-ray-based light-controlled photoimmunotherapy, other innovative treatments that regulated light. We introduce basic principles characteristics lanthanide nanoparticles. Following this, summarize latest advances utilizing phototherapy, focusing on design principles, mechanisms action, cancer treatment. To conclude, address existing explore future within area research.

Language: Английский

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Metal–Organic Framework Nanocomposites in Conquering Hypoxia for Tumor Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(17)

Published: Jan. 3, 2024

Abstract Hypoxia, as a distinctive feature of tumors, is closely related to tumor recurrence, metastasis, and treatment resistance. Metal–organic framework (MOF) exhibits an increasing number advantages in cancer therapy owing its porous structure, large specific surface area, tunable function. The MOF nanocomposites constructed by adjusting components can effectively overcome hypoxia significantly enhance the anti‐tumor effect. In this review, hypoxic characteristics tumors current strategies for constructing that are summarized, including delivering O 2 or endogenously generating elevate intra‐tumor content; inhibiting HIF‐1 induced products alleviate hypoxia; reducing cellular aerobic respiration decrease consumption, exacerbating improve efficacy hypoxia‐activated pre‐drugs. At same time, applications applied different therapeutic methods at present stage described, finally, challenges opportunities further development discussed.

Language: Английский

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Nanoplatform-based strategies for enhancing the lethality of current antitumor PDT

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(13), P. 3209 - 3225

Published: Jan. 1, 2024

This review summarizes the recent advances of nanoplatform-based strategies to efficiently amplify tumoricidal capability PDT.

Language: Английский

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Metal organic framework–based variable-size nanoparticles for tumor microenvironment-responsive drug delivery

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(7), P. 1737 - 1755

Published: Feb. 8, 2024

Language: Английский

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A Two-Pronged Delivery Strategy Disrupting Positive Feedback Loop of Neutrophil Extracellular Traps for Metastasis Suppression

ACS Nano, Journal Year: 2024, Volume and Issue: 18(24), P. 15432 - 15451

Published: June 6, 2024

Neutrophil extracellular traps (NETs) severely affect tumor metastasis through a self-perpetuating feedback loop involving two key steps: (1) mitochondrial aerobic respiration-induced hypoxia promotes NET formation and (2) NETs enhance metabolism to exacerbate hypoxia. Herein, we propose two-pronged approach with the activity of NET-degrading mitochondrion-damaging by simultaneously targeting drugs mitochondria this loop. In addition specifically recognizing eliminating extant NETs, NET-targeting nanoparticle also reduces NET-induced biogenesis, thus inhibiting initial step mitigating NETs' impact on metastasis. Simultaneously, mitochondrion-targeting system intercepts alleviates hypoxia, neutrophil infiltration subsequent formation, which source disrupts another self-amplifying Together, combination significantly NET–tumor cell clusters disrupting interaction between mitochondria, thereby impeding metastatic cascade including invasion, hematogenous spread, distant colonization. This work represents an innovative attempt disrupt in metastasis, offering promising therapeutic restraining NET-assisted

Language: Английский

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Based on polydopamine-coated metal organic framework multifunctional nanoplatform for enhanced photothermal/sonodynamicand treatment combined with checkpoint blockade therapy

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 132207 - 132207

Published: May 7, 2024

Language: Английский

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Multi‐Enzyme Nanoparticles as Efficient Pyroptosis and Immunogenic Cell Death Inducers for Cancer Immunotherapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(44)

Published: Oct. 9, 2024

Abstract Immunotherapy represents a widely employed modality in clinical oncology, leveraging the activation of human immune system to target and eradicate cancer cells tumor tissues via endogenous mechanisms. However, its efficacy remains constrained by inadequate responses within “cold” microenvironment (TME). In this study, multifunctional nanoscale pyroptosis inducer with cascade enzymatic activity (IMZF), comprising superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione oxidase (GSHO x ), is dissociated acidic glutathione‐rich TME. The vigorous not only generates oxygen (O 2 ) alleviate hypoxia promote M2 M1 macrophage polarization but also yields reactive species (ROS) depletes (GSH) Functioning as an immunogenic cell death (ICD) activator inducer, IMZF synergistically triggers dendritic maturation inflammatory lymphocyte infiltration ICD‐associated pyroptosis, thereby reversing suppression TMEs. Consequently, it exerts inhibitory effects on both primary distal tumors. This platform‐based offers intelligent strategy for effectively overcoming tumors, providing promising avenue advanced immunotherapeutic interventions.

Language: Английский

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Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions

Materials Advances, Journal Year: 2023, Volume and Issue: 5(2), P. 409 - 431

Published: Dec. 21, 2023

Cancer is a highly complex disease that affects lives and causes millions of deaths worldwide.

Language: Английский

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An antioxidative-enhanced endoplasmic reticulum-targeted cyanine dye for efficient tumor immunotherapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 494, P. 153089 - 153089

Published: June 13, 2024

Language: Английский

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Recent progress of porphyrin metal-organic frameworks for combined photodynamic therapy and hypoxia-activated chemotherapy

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(93), P. 13641 - 13652

Published: Jan. 1, 2024

Hypoxia limits the phototherapeutic efficacy of porphyrin-based nMOFs; loading with hypoxia-activated drug TPZ enhances combined PDT and chemotherapy effects.

Language: Английский

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