The Chemical Record,
Год журнала:
2024,
Номер
24(4)
Опубликована: Март 19, 2024
Abstract
Layered
double
hydroxides
(LDH)
are
a
class
of
functional
anionic
clays
that
typically
consist
orthorhombic
arrays
metal
with
anions
sandwiched
between
the
layers.
Due
to
their
unique
properties,
including
high
chemical
stability,
good
biocompatibility,
controlled
drug
loading,
and
enhanced
bioavailability,
LDHs
have
many
potential
applications
in
medical
field.
Especially
fields
bioimaging
tumor
therapy.
This
paper
reviews
research
progress
nanocomposites
field
imaging
First,
structure
advantages
LDH
discussed.
Then,
several
commonly
used
methods
for
preparation
presented,
co‐precipitation,
hydrothermal
ion
exchange
methods.
Subsequently,
recent
advances
layered
cancer
therapy
highlighted.
Finally,
based
on
current
research,
we
summaries
prospects
challenges
diagnosis
Chemical Society Reviews,
Год журнала:
2021,
Номер
51(2), С. 566 - 593
Опубликована: Дек. 20, 2021
The
real-time,
dynamic
optical
visualization
of
lesions
and
margins
ensures
not
only
complete
resection
the
malignant
tissues
but
also
better
preservation
vital
organs/tissues
during
surgical
procedures.
Most
imaging
probes
with
an
"always-on"
signal
encounter
high
background
noise
due
to
their
non-specific
accumulation
in
normal
tissues.
By
contrast,
activatable
molecular
"turn
on"
signals
upon
reaction
targeted
biomolecules
that
are
overexpressed
cells,
offering
target-to-background
ratios
specificity
sensitivity.
This
review
summarizes
recent
progress
diagnosis.
design
principle
mechanism
discussed,
followed
by
specific
emphasis
on
applications
ranging
from
fluorescence-guided
surgery
endoscopy
tissue
biopsy.
Finally,
potential
challenges
perspectives
field
probe-enabled
discussed.
Advanced Materials,
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 10, 2023
Rapid
advancements
in
materials
science
and
nanotechnology,
intertwined
with
oncology,
have
positioned
photothermal
therapy
(PTT)
as
a
promising
noninvasive
treatment
strategy
for
cancer.
The
breast's
superficial
anatomical
location
aesthetic
significance
render
breast
cancer
particularly
pertinent
candidate
the
clinical
application
of
PTT
following
melanoma.
This
review
comprehensively
explores
research
conducted
on
various
types
nanoparticles
employed
elaborates
their
specific
roles
mechanisms
action.
integration
existing
therapies
is
scrutinized,
underscoring
its
potential
synergistic
outcomes.
Additionally,
underlying
consequential
modifications
to
tumor
microenvironment
after
are
elaborated
from
medical
perspective.
Future
directions
suggested,
an
emphasis
development
integrative
platforms
that
combine
multiple
therapeutic
approaches
optimization
nanoparticle
synthesis
enhanced
efficacy.
goal
push
boundaries
toward
comprehensive,
clinically
applicable
Chemical Reviews,
Год журнала:
2023,
Номер
124(2), С. 554 - 628
Опубликована: Ноя. 22, 2023
In
vivo
imaging
technologies
have
emerged
as
a
powerful
tool
for
both
fundamental
research
and
clinical
practice.
particular,
luminescence
in
the
tissue-transparent
near-infrared
(NIR,
700–1700
nm)
region
offers
tremendous
potential
visualizing
biological
architectures
pathophysiological
events
living
subjects
with
deep
tissue
penetration
high
contrast
owing
to
reduced
light–tissue
interactions
of
absorption,
scattering,
autofluorescence.
The
distinctive
quantum
effects
nanocrystals
been
harnessed
achieve
exceptional
photophysical
properties,
establishing
them
promising
category
luminescent
probes.
this
comprehensive
review,
between
light
tissues,
well
advantages
NIR
imaging,
are
initially
elaborated.
Subsequently,
we
focus
on
achieving
improved
by
optimizing
performance
nanocrystal
fluorophores.
ingenious
design
strategies
probes
discussed,
along
their
respective
biomedical
applications
versatile
modalities.
Finally,
thought-provoking
reflections
challenges
prospects
future
translation
nanocrystal-based
wisely
provided.
Advanced Materials,
Год журнала:
2022,
Номер
34(17)
Опубликована: Март 3, 2022
Much
effort
is
devoted
to
develop
agents
with
superior
photoacoustic/photothermal
properties
for
improved
disease
diagnosis
and
treatment.
Herein,
a
new
fused
two
isoindigo
(DIID)-based
semiconducting
conjugated
polymer
(named
PBDT-DIID)
rationally
designed
synthesized
strong
near-infrared
absorption
band
ranging
from
700
1000
nm.
Water-dispersing
nanoparticles
(NPs)
of
PBDT-DIID
are
prepared
good
biocompatibility
rather
high
photothermal
conversion
efficiency
(70.6%),
as
the
active
excited-state
intramolecular
twist
around
central
double
bonds
in
DIID
permits
most
absorbed
excitation
energy
flow
heat
deactivation
pathway
through
internal
conversion.
The
photoacoustic
signal
can
be
further
magnified
by
incorporation
polylactide
(PLA)
NP
core
confine
generated
within
NPs.
resultant
doped
NPs
show
excellent
performance
imaging-guided
therapy
an
orthotopic
4T1
breast
tumor-bearing
mouse
model.
It
also
found
that
effect
safe
quite
efficacious
highly
improve
root
canal
treatment
outcome
heating
1%
NaClO
solution
inside
upon
808
nm
laser
irradiation
human
extracted
tooth
infection
Advanced Materials,
Год журнала:
2022,
Номер
34(19)
Опубликована: Март 21, 2022
Materials
with
long-wavelength
second
near-infrared
(NIR-II)
emission
are
highly
desired
for
in
vivo
dynamic
visualizating
of
microstructures
deep
tissues.
Herein,
by
employing
an
atom-programming
strategy,
a
series
fluorescent
semiconducting
oligomers
(SOMs)
tunable
NIR-IIb
emissions
developed
bioimaging
applications.
After
self-assembly
into
nanoparticles
(NPs),
they
show
good
brightness,
high
photostability,
and
satisfactory
biocompatibility.
The
SOM
NPs
applied
as
probes
high-resolution
imaging
whole-body
hind-limb
blood
vessels,
biliary
tract,
bladder
their
over
1500
nm.
This
work
demonstrates
strategy
constructing
small
molecules
enhanced
NIR-II
fluorescence
deep-tissue
imaging,
affording
new
insight
advancing
molecular
design
fluorophores.
Advanced Materials,
Год журнала:
2023,
Номер
35(35)
Опубликована: Апрель 20, 2023
Photothermal
therapy
(PTT)
has
received
increasing
interest
in
cancer
therapeutics
owing
to
its
excellent
efficacy
and
controllability.
However,
there
are
two
major
limitations
PTT
applications,
which
the
tissue
penetration
depth
of
lasers
within
absorption
range
photothermal
agents
unavoidable
empyrosis
induced
by
high-energy
lasers.
Herein,
a
gas/phototheranostic
nanocomposite
(NA1020-NO@PLX)
is
engineered
that
integrates
second
near-infrared-peak
(NIR-II-peak)
absorbing
aza-boron-dipyrromethenes
(aza-BODIPY,NA1020)
with
thermal-sensitive
nitric
oxide
(NO)
donor
(S-nitroso-N-acetylpenicillamine,
SNAP).
An
enhanced
intramolecular
charge
transfer
mechanism
proposed
achieve
NIR-II-peak
absorbance
(λmax
=
1020
nm)
on
NA1020,
thereby
obtaining
deep
depth.
The
NA1020
exhibits
remarkable
conversion,
making
it
feasible
for
deep-tissue
orthotopic
osteosarcoma
providing
favorable
NIR-II
emission
precisely
pinpoint
tumor
visible
process.
simultaneously
investigated
atraumatic
therapeutic
process
an
cell
apoptosis
indicates
feasibility
synergistic
NO/low-temperature
osteosarcoma.
this
strategy
optimizes
existing
present
repeatable
tumors,
validating
potential
clinical
applications.
ACS Nano,
Год журнала:
2024,
Номер
18(5), С. 3916 - 3968
Опубликована: Янв. 23, 2024
Dynamic
variations
in
the
concentration
and
abnormal
distribution
of
endogenous
biomarkers
are
strongly
associated
with
multiple
physiological
pathological
states.
Therefore,
it
is
crucial
to
design
imaging
systems
capable
real-time
detection
dynamic
changes
for
accurate
diagnosis
effective
treatment
diseases.
Recently,
ratiometric
has
emerged
as
a
widely
used
technique
sensing
due
its
advantage
circumventing
limitations
inherent
conventional
intensity-dependent
signal
readout
methods
while
also
providing
built-in
self-calibration
correction.
Here,
recent
progress
probes
their
applications
outlined.
Ratiometric
classified
according
mechanisms,
photoacoustic
imaging,
optical
including
photoluminescence
self-luminescence
magnetic
resonance
dual-modal
discussed.
The
such
pH,
reactive
oxygen
species
(ROS),
nitrogen
(RNS),
glutathione
(GSH),
gas
molecules,
enzymes,
metal
ions,
hypoxia
discussed
detail.
Additionally,
this
Review
presents
an
overview
challenges
faced
field
along
future
research
directions.
