An Immunoregulation Hydrogel with Controlled Hyperthermia‐Augmented Oxygenation and ROS Scavenging for Treating Diabetic Foot Ulcers

Advanced Functional Materials, Год журнала: 2024, Номер 34(33)

Опубликована: Май 6, 2024

Abstract Diabetic foot ulcers (DFUs), a serious and increasingly common chronic issue among diabetics, often do not respond well to generalized treatment strategies. Hypoxia the overexpression of reactive oxygen species (ROS), resulting in inflammatory dysregulation subsequent imbalance macrophage phenotypes, are critical factors contributing prolonged non‐healing DFU wounds. These two issues interact continuous, problematic cycle. Presently, there is lack comprehensive strategies aimed at addressing both these simultaneously interrupt this detrimental Herein, an immunomodulatory hydrogel (PHG2) developed for reshaping hostile microenvironment. The engineered PHG2 only removes excess internally‐produced ROS but also generates O 2 , with its efficiency further boosted by local hyperthermia (42.5 °C) activated near‐infrared light. Through vitro vivo studies, along transcriptomic assessment, it confirmed that disrupts feedback loop between inflammation while lowering M1/M2 ratio. Such discoveries contribute significant enhancement healing process injuries undergo gradual increase movement, covering wounds from back, mouth, foot. Ultimately, method provides easy, safe, highly effective solution treating DFUs.

Язык: Английский

---

Multifunctional polypeptide-based hydrogel bio-adhesives with pro-healing activities and their working principles

Advances in Colloid and Interface Science, Год журнала: 2024, Номер 327, С. 103155 - 103155

Опубликована: Апрель 16, 2024

Язык: Английский

---

Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings

Gels, Год журнала: 2025, Номер 11(2), С. 123 - 123

Опубликована: Фев. 7, 2025

Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.

Язык: Английский

---

Advancements and Challenges in Self-Healing Hydrogels for Wound Care

Gels, Год журнала: 2024, Номер 10(4), С. 241 - 241

Опубликована: Апрель 1, 2024

This manuscript explores self-healing hydrogels as innovative solutions for diverse wound management challenges. Addressing antibiotic resistance and tailored care, these exhibit promising outcomes, including accelerated closure tissue regeneration. Advancements in multifunctional with controlled drug release, antimicrobial properties, real-time assessment capabilities signal a significant leap toward patient-centered treatments. However, challenges such scalability, long-term safety evaluation, variability clinical outcomes persist. Future directions emphasize personalized medicine, manufacturing innovation, rigorous evaluation through trials, interdisciplinary collaboration. features the ongoing pursuit of effective, adaptable, comprehensive care to transform medical treatments improve patient outcomes.

Язык: Английский

---

Transparent, Self-Healing, and Defogging Wearable Devices Enabled by Plasmonic Silver Nanoparticle-Embedded Covalent–Organic Framework Nanosheets

ACS Materials Letters, Год журнала: 2024, Номер 6(2), С. 648 - 655

Опубликована: Янв. 22, 2024

The development of transparent wearable devices capable self-healing and efficient fog removal is great significance. In this study, we have realized the fabrication a composite film exhibiting remarkable transparency along with light-triggered healing defogging capabilities. This was achieved by integrating plasmonic silver nanoparticle (AgNPs) embedded covalent–organic framework (COF) nanosheets, denoted as AgNPs/CONs, into waterborne elastic polyurethane (PU) matrix. Due to synergistic effect between AgNPs high properties COF nanosheets excellent photothermal characteristics, resulting film, even an ultralow loading AgNPs/CONs (0.15 wt %), demonstrate rapid temperature increase 80 °C upon exposure 500 mW cm–2 near-infrared (NIR) light irradiation for 12 s. Simultaneously, it maintains optical transmittance 96.2% at thin thickness 20 μm extremely low (0.08 %). localized elevation effectively eliminates surface promotes mechanical damage within achieving efficiency exceeding 98%. Our findings represent significant advancement in design photothermally active materials based on COFs, opening up new prospects next-generation electronic applications.

Язык: Английский

---

ROS-Responsive Hydrogels: from Design, Additive Manufacturing to Biomedical Applications

Materials Horizons, Год журнала: 2024, Номер 11(16), С. 3721 - 3746

Опубликована: Янв. 1, 2024

Hydrogels with intricate 3D networks and high hydrophilicity have qualities resembling those of biological tissues, making them ideal candidates for use as smart biomedical materials. Reactive oxygen species (ROS) responsive hydrogels are an innovative class hydrogels, cross-linked by ROS-responsive modules through covalent interactions, coordination or supramolecular interactions. Due to the introduction ROS response modules, this exhibits a sensitive oxidative stress microenvironment existing in organisms. Simultaneously, due modularity structure, can be manufactured on large scale additive manufacturing. This review will delve into design, fabrication, applications hydrogels. The main goal is clarify chemical principles that govern mechanism these further providing new perspectives methods designing hydrogel

Язык: Английский

---

Microenvironmental dynamics of diabetic wounds and insights for hydrogel-based therapeutics

Journal of Tissue Engineering, Год журнала: 2024, Номер 15

Опубликована: Янв. 1, 2024

The rising prevalence of diabetes has underscored concerns surrounding diabetic wounds and their potential to induce disability. intricate healing mechanisms are multifaceted, influenced by ambient microenvironment, including prolonged hyperglycemia, severe infection, inflammation, elevated levels reactive oxygen species (ROS), ischemia, impaired vascularization, altered wound physicochemical properties. In recent years, hydrogels have emerged as promising candidates for treatment owing exceptional biocompatibility resemblance the extracellular matrix (ECM) through a three-dimensional (3D) porous network. This review will first summarize microenvironment alterations occurring in wounds, aiming provide comprehensive understanding its pathogenesis, then classification recently developed be presented, encompassing properties such hypoglycemic effects, anti-inflammatory capabilities, antibacterial attributes, ROS scavenging abilities, promotion angiogenesis, pH responsiveness, more. primary objective is offer valuable reference repairing based on unique microenvironment. Moreover, this paper outlines avenues future advancements hydrogel dressings facilitate expedite process wounds.

Язык: Английский

---

ROS sensitive adaptive injectable hydrogels Based on GAPBA nanofibers and PVA/EGCG for accelerating diabetic wound healing through regulating the inflammation microenvironment

European Polymer Journal, Год журнала: 2025, Номер unknown, С. 113723 - 113723

Опубликована: Янв. 1, 2025

Язык: Английский

---

A 3-in-1 wearable and implantable biopatch for integrated in-body energy harvesting, sensing, and self-powered diabetic wound treatments

Nano Energy, Год журнала: 2025, Номер unknown, С. 110743 - 110743

Опубликована: Фев. 1, 2025

Язык: Английский

---

Catalase-like Nanozyme-Hybrid Hydrogels Utilizing Endogenous ROS as an Oxygen Source To Synergically Regulate Oxidative Stress and Hypoxia for Enhanced Diabetic Wound Healing

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

High levels of reactive oxygen species (ROS) and hypoxia in diabetic wounds significantly hinder the healing process. In this work, a kind catalase-like nanozyme-hybrid hydrogel was developed to explore potential harnessing endogenous excessive ROS as an source synergistically regulate oxidative stress hypoxia, thereby enhancing wound healing. The hydrogels exhibited rapid degradation controlled release ferrihydrite nanozymes response stress, which continuously catalyzed decomposition H2O2 generate oxygen, effectively scavenging reducing risk local toxicity. relieved intracellular hypoxic microenvironment simultaneously vitro. dressings inhibited damage at sites, promoted epidermis formation collagen deposition, accelerated db/db mice. Therefore, represent promising strategy for dressings, addressing both improve outcomes.

Язык: Английский

---